TY  - JOUR
TI  - Autoimmunity and immunodeficiency at the crossroad: autoimmune disorders as the presenting feature of selective IgM deficiency
AV  - public
VL  - 12
Y1  - 2019/01/03/
N1  - This version is the author accepted manuscript. For information on re-use, please refer to the publisher?s terms and conditions.
IS  - 1
ID  - discovery10065788
N2  - Selective immunoglobulin M deficiency (sIgMD) is an immunodeficiency with undefined pathogenesis and commonly presenting with recurrent infections. 1 The European Society for Immunodeficiencies Registry defines sIgMD as a serum IgM level repeatedly below 2 SD of normal with normal levels of serum IgA, IgG and IgG subclasses, normal vaccination responses, absence of T-cell defects and absence of causative external factors. Rarely it can also be associated with autoimmune diseases. 2-7 Here we describe a patient with primary sIgMD; who presented with multiple autoimmune diseases without a history of recurrent infections and we provide a short literature review on sIgMD and autoimmune diseases.
SN  - 1757-790X
UR  - http://dx.doi.org/10.1136/bcr-2017-223180
JF  - BMJ Case Reports
KW  - connective tissue disease
KW  -  immunology
A1  - Campochiaro, C
A1  - Atay, S
A1  - Clark, KEN
A1  - Ong, V
A1  - Denton, CP
ER  -