@article{discovery10065429, number = {1}, title = {Intracranial Arterial 4D Flow in Individuals with Mild Cognitive Impairment is Associated with Cognitive Performance and Amyloid Positivity}, year = {2017}, volume = {60}, publisher = {IOS PRESS}, note = {This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.}, pages = {243--252}, journal = {Journal of Alzheimer's Disease}, month = {August}, abstract = {It is becoming increasingly recognized that cerebrovascular disease is a contributing factor in the pathogenesis of Alzheimer's disease (AD). A unique 4D-Flow magnetic resonance imaging (MRI) technique, phase contrast vastly undersampled isotropic projection imaging (PC VIPR), enables examination of angiographic and quantitative metrics of blood flow in the arteries of the Circle of Willis within a single MRI acquisition. Thirty-eight participants with mild cognitive impairment (MCI) underwent a comprehensive neuroimaging protocol (including 4D-Flow imaging) and a standard neuropsychological battery. A subset of participants (nā=ā22) also underwent lumbar puncture and had cerebrospinal fluid (CSF) assayed for AD biomarkers. Cut-offs for biomarker positivity in CSF resulting from a receiver operating characteristic curve analysis of AD cases and controls from the larger Wisconsin Alzheimer's Disease Research Center cohort were used to classify MCI participants as biomarker positive or negative on amyloid-{\ensuremath{\beta}} (A{\ensuremath{\beta}}42), total-tau and total-tau/A{\ensuremath{\beta}}42 ratio. Internal carotid artery (ICA) and middle cerebral artery (MCA) mean flow were associated with executive functioning performance, with lower mean flow corresponding to worse performance. MCI participants who were biomarker positive for A{\ensuremath{\beta}}42 had lower ICA mean flow than did those who were A{\ensuremath{\beta}}42 negative. In sum, mean ICA and MCA arterial flow was associated with cognitive performance in participants with MCI and lower flow in the ICA was associated with amyloid positivity. This provides further evidence for vascular health as a contributing factor in the etiopathogenesis of AD, and could represent a point to intervene in the disease process.}, author = {Berman, SE and Clark, LR and Rivera-Rivera, LA and Norton, D and Racine, AM and Rowley, HA and Bendlin, BB and Blennow, K and Zetterberg, H and Carlsson, CM and Asthana, S and Turski, P and Wieben, O and Johnson, SC}, url = {http://doi.org/10.3233/JAD-170402}, issn = {1875-8908}, keywords = {Aging, Alzheimer's disease, cerebrovascular disease, mild cognitive impairment} }