eprintid: 10065062
rev_number: 16
eprint_status: archive
userid: 608
dir: disk0/10/06/50/62
datestamp: 2019-01-07 13:41:36
lastmod: 2021-10-23 22:49:32
status_changed: 2019-01-07 13:41:36
type: article
metadata_visibility: show
creators_name: Sandelius, A
creators_name: Cullen, NC
creators_name: Kallen, A
creators_name: Rosengren, L
creators_name: Jensen, C
creators_name: Kostanjevecki, V
creators_name: Vandijck, M
creators_name: Zetterberg, H
creators_name: Blennow, K
title: Transient increase in CSF GAP-43 concentration after ischemic stroke
ispublished: pub
divisions: UCL
divisions: B02
divisions: C07
divisions: D07
divisions: F86
keywords: GAP-43, Stroke, Neurodegeneration, Cerebrospinal fluid, Biomarkers
note: Copyright © The Author(s). 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0
International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and
reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to
the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver
(http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
abstract: Background: Cerebrospinal fluid (CSF) biomarkers reflect ongoing processes in the brain. Growth-associated
protein 43 (GAP-43) is highly upregulated in brain tissue shortly after experimental ischemia suggesting the CSF
GAP-43 concentration may be altered in ischemic brain disorders. CSF GAP-43 concentration is elevated in
Alzheimer’s disease patients; however, patients suffering from stroke have not been studied previously.
Methods: The concentration of GAP-43 was measured in longitudinal CSF samples from 28 stroke patients
prospectively collected on days 0–1, 2–4, 7–9, 3 weeks, and 3–5 months after ischemia and cross-sectionally in 19
controls. The stroke patients were clinically evaluated using a stroke severity score system. The extent of the brain
lesion, including injury size and degrees of white matter lesions and atrophy were evaluated by CT and magnetic
resonance imaging.
Results: Increased GAP-43 concentration was detected from day 7–9 to 3 weeks after stroke, compared to day 1–4
and to levels in the control group (P = 0.02 and P = 0.007). At 3–5 months after stroke GAP-43 returned to admission
levels. The initial increase in GAP-43 during the nine first days was associated to stroke severity, the degree of white
matter lesions and atrophy and correlated positively with infarct size (rs = 0.65, P = 0.001).
Conclusions: The transient increase of CSF GAP-43 is important to take into account when used as a biomarker for
other neurodegenerative diseases such as Alzheimer’s disease. Furthermore, GAP-43 may be a marker of neuronal
responses after stroke and additional studies confirming the potential of CSF GAP-43 to reflect severity and
outcome of stroke in larger cohorts are warranted.
date: 2018-12-07
date_type: published
publisher: BMC
official_url: http://doi.org/10.1186/s12883-018-1210-5
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1608824
doi: 10.1186/s12883-018-1210-5
lyricists_name: Zetterberg, Henrik
lyricists_id: HZETT94
actors_name: Bracey, Alan
actors_id: ABBRA90
actors_role: owner
full_text_status: public
publication: BMC Neurology
volume: 18
article_number: 202
pages: 8
issn: 1471-2377
citation:        Sandelius, A;    Cullen, NC;    Kallen, A;    Rosengren, L;    Jensen, C;    Kostanjevecki, V;    Vandijck, M;         ... Blennow, K; + view all <#>        Sandelius, A;  Cullen, NC;  Kallen, A;  Rosengren, L;  Jensen, C;  Kostanjevecki, V;  Vandijck, M;  Zetterberg, H;  Blennow, K;   - view fewer <#>    (2018)    Transient increase in CSF GAP-43 concentration after ischemic stroke.                   BMC Neurology , 18     , Article 202.  10.1186/s12883-018-1210-5 <https://doi.org/10.1186/s12883-018-1210-5>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10065062/1/s12883-018-1210-5.pdf