eprintid: 10065033 rev_number: 20 eprint_status: archive userid: 608 dir: disk0/10/06/50/33 datestamp: 2019-01-09 10:21:23 lastmod: 2021-11-30 23:03:14 status_changed: 2019-01-09 10:21:23 type: article metadata_visibility: show creators_name: Takeuchi, F creators_name: Akiyama, M creators_name: Matoba, N creators_name: Katsuya, T creators_name: Nakatochi, M creators_name: Tabara, Y creators_name: Narita, A creators_name: Saw, W-Y creators_name: Moon, S creators_name: Spracklen, CN creators_name: Chai, J-F creators_name: Kim, Y-J creators_name: Zhang, L creators_name: Wang, C creators_name: Li, H creators_name: Li, H creators_name: Wu, J-Y creators_name: Dorajoo, R creators_name: Nierenberg, JL creators_name: Wang, YX creators_name: He, J creators_name: Bennett, DA creators_name: Takahashi, A creators_name: Momozawa, Y creators_name: Hirata, M creators_name: Matsuda, K creators_name: Rakugi, H creators_name: Nakashima, E creators_name: Isono, M creators_name: Shirota, M creators_name: Hozawa, A creators_name: Ichihara, S creators_name: Matsubara, T creators_name: Yamamoto, K creators_name: Kohara, K creators_name: Igase, M creators_name: Han, S creators_name: Gordon-Larsen, P creators_name: Huang, W creators_name: Lee, NR creators_name: Adair, LS creators_name: Hwang, MY creators_name: Lee, J creators_name: Chee, ML creators_name: Sabanayagam, C creators_name: Zhao, W creators_name: Liu, J creators_name: Reilly, DF creators_name: Sun, L creators_name: Huo, S creators_name: Edwards, TL creators_name: Long, J creators_name: Chang, L-C creators_name: Chen, C-H creators_name: Yuan, J-M creators_name: Koh, W-P creators_name: Friedlander, Y creators_name: Kelly, TN creators_name: Bin Wei, W creators_name: Xu, L creators_name: Cai, H creators_name: Xiang, Y-B creators_name: Lin, K creators_name: Clarke, R creators_name: Walters, RG creators_name: Millwood, IY creators_name: Li, L creators_name: Chambers, JC creators_name: Kooner, JS creators_name: Elliott, P creators_name: van der Harst, P creators_name: International Genomics of Blood Pressure (iGEN-BP) Consortium, . creators_name: Chen, Z creators_name: Sasaki, M creators_name: Shu, X-O creators_name: Jonas, JB creators_name: He, J creators_name: Heng, C-K creators_name: Chen, Y-T creators_name: Zheng, W creators_name: Lin, X creators_name: Teo, Y-Y creators_name: Tai, E-S creators_name: Cheng, C-Y creators_name: Wong, TY creators_name: Sim, X creators_name: Mohlke, KL creators_name: Yamamoto, M creators_name: Kim, B-J creators_name: Miki, T creators_name: Nabika, T creators_name: Yokota, M creators_name: Kamatani, Y creators_name: Kubo, M creators_name: Kato, N title: Interethnic analyses of blood pressure loci in populations of East Asian and European descent ispublished: pub divisions: UCL divisions: B02 divisions: D12 divisions: G19 divisions: DD4 keywords: Asian Continental Ancestry Group, Blood Pressure, Continental Population Groups, Europe, European Continental Ancestry Group, Female, Genetic Loci, Genome-Wide Association Study, Humans, Linkage Disequilibrium, Male, Polymorphism, Single Nucleotide note: This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. abstract: Blood pressure (BP) is a major risk factor for cardiovascular disease and more than 200 genetic loci associated with BP are known. Here, we perform a multi-stage genome-wide association study for BP (max N = 289,038) principally in East Asians and meta-analysis in East Asians and Europeans. We report 19 new genetic loci and ancestry-specific BP variants, conforming to a common ancestry-specific variant association model. At 10 unique loci, distinct non-rare ancestry-specific variants colocalize within the same linkage disequilibrium block despite the significantly discordant effects for the proxy shared variants between the ethnic groups. The genome-wide transethnic correlation of causal-variant effect-sizes is 0.898 and 0.851 for systolic and diastolic BP, respectively. Some of the ancestry-specific association signals are also influenced by a selective sweep. Our results provide new evidence for the role of common ancestry-specific variants and natural selection in ethnic differences in complex traits such as BP. date: 2018-11-28 date_type: published official_url: https://doi.org/10.1038/s41467-018-07345-0 oa_status: green full_text_type: pub pmcid: PMC6261994 language: eng primo: open primo_central: open_green article_type_text: Journal Article verified: verified_manual elements_id: 1614740 doi: 10.1038/s41467-018-07345-0 pii: 10.1038/s41467-018-07345-0 lyricists_name: Asselbergs, Folkert lyricists_name: Kivimaki, Mika lyricists_id: FASSE08 lyricists_id: MJKIV95 actors_name: Bracey, Alan actors_id: ABBRA90 actors_role: owner full_text_status: public publication: Nature Communications volume: 9 number: 1 article_number: 5052 event_location: England issn: 2041-1723 citation: Takeuchi, F; Akiyama, M; Matoba, N; Katsuya, T; Nakatochi, M; Tabara, Y; Narita, A; ... Kato, N; + view all <#> Takeuchi, F; Akiyama, M; Matoba, N; Katsuya, T; Nakatochi, M; Tabara, Y; Narita, A; Saw, W-Y; Moon, S; Spracklen, CN; Chai, J-F; Kim, Y-J; Zhang, L; Wang, C; Li, H; Li, H; Wu, J-Y; Dorajoo, R; Nierenberg, JL; Wang, YX; He, J; Bennett, DA; Takahashi, A; Momozawa, Y; Hirata, M; Matsuda, K; Rakugi, H; Nakashima, E; Isono, M; Shirota, M; Hozawa, A; Ichihara, S; Matsubara, T; Yamamoto, K; Kohara, K; Igase, M; Han, S; Gordon-Larsen, P; Huang, W; Lee, NR; Adair, LS; Hwang, MY; Lee, J; Chee, ML; Sabanayagam, C; Zhao, W; Liu, J; Reilly, DF; Sun, L; Huo, S; Edwards, TL; Long, J; Chang, L-C; Chen, C-H; Yuan, J-M; Koh, W-P; Friedlander, Y; Kelly, TN; Bin Wei, W; Xu, L; Cai, H; Xiang, Y-B; Lin, K; Clarke, R; Walters, RG; Millwood, IY; Li, L; Chambers, JC; Kooner, JS; Elliott, P; van der Harst, P; International Genomics of Blood Pressure (iGEN-BP) Consortium, .; Chen, Z; Sasaki, M; Shu, X-O; Jonas, JB; He, J; Heng, C-K; Chen, Y-T; Zheng, W; Lin, X; Teo, Y-Y; Tai, E-S; Cheng, C-Y; Wong, TY; Sim, X; Mohlke, KL; Yamamoto, M; Kim, B-J; Miki, T; Nabika, T; Yokota, M; Kamatani, Y; Kubo, M; Kato, N; - view fewer <#> (2018) Interethnic analyses of blood pressure loci in populations of East Asian and European descent. Nature Communications , 9 (1) , Article 5052. 10.1038/s41467-018-07345-0 <https://doi.org/10.1038/s41467-018-07345-0>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10065033/1/s41467-018-07345-0.pdf