@article{discovery10065033,
         journal = {Nature Communications},
          number = {1},
            year = {2018},
           title = {Interethnic analyses of blood pressure loci in populations of East Asian and European descent},
           month = {November},
            note = {This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.},
          volume = {9},
            issn = {2041-1723},
          author = {Takeuchi, F and Akiyama, M and Matoba, N and Katsuya, T and Nakatochi, M and Tabara, Y and Narita, A and Saw, W-Y and Moon, S and Spracklen, CN and Chai, J-F and Kim, Y-J and Zhang, L and Wang, C and Li, H and Li, H and Wu, J-Y and Dorajoo, R and Nierenberg, JL and Wang, YX and He, J and Bennett, DA and Takahashi, A and Momozawa, Y and Hirata, M and Matsuda, K and Rakugi, H and Nakashima, E and Isono, M and Shirota, M and Hozawa, A and Ichihara, S and Matsubara, T and Yamamoto, K and Kohara, K and Igase, M and Han, S and Gordon-Larsen, P and Huang, W and Lee, NR and Adair, LS and Hwang, MY and Lee, J and Chee, ML and Sabanayagam, C and Zhao, W and Liu, J and Reilly, DF and Sun, L and Huo, S and Edwards, TL and Long, J and Chang, L-C and Chen, C-H and Yuan, J-M and Koh, W-P and Friedlander, Y and Kelly, TN and Bin Wei, W and Xu, L and Cai, H and Xiang, Y-B and Lin, K and Clarke, R and Walters, RG and Millwood, IY and Li, L and Chambers, JC and Kooner, JS and Elliott, P and van der Harst, P and International Genomics of Blood Pressure (iGEN-BP) Consortium, . and Chen, Z and Sasaki, M and Shu, X-O and Jonas, JB and He, J and Heng, C-K and Chen, Y-T and Zheng, W and Lin, X and Teo, Y-Y and Tai, E-S and Cheng, C-Y and Wong, TY and Sim, X and Mohlke, KL and Yamamoto, M and Kim, B-J and Miki, T and Nabika, T and Yokota, M and Kamatani, Y and Kubo, M and Kato, N},
             url = {https://doi.org/10.1038/s41467-018-07345-0},
        abstract = {Blood pressure (BP) is a major risk factor for cardiovascular disease and more than 200 genetic loci associated with BP are known. Here, we perform a multi-stage genome-wide association study for BP (max N = 289,038) principally in East Asians and meta-analysis in East Asians and Europeans. We report 19 new genetic loci and ancestry-specific BP variants, conforming to a common ancestry-specific variant association model. At 10 unique loci, distinct non-rare ancestry-specific variants colocalize within the same linkage disequilibrium block despite the significantly discordant effects for the proxy shared variants between the ethnic groups. The genome-wide transethnic correlation of causal-variant effect-sizes is 0.898 and 0.851 for systolic and diastolic BP, respectively. Some of the ancestry-specific association signals are also influenced by a selective sweep. Our results provide new evidence for the role of common ancestry-specific variants and natural selection in ethnic differences in complex traits such as BP.},
        keywords = {Asian Continental Ancestry Group, Blood Pressure, Continental Population Groups, Europe, European Continental Ancestry Group, Female, Genetic Loci, Genome-Wide Association Study, Humans, Linkage Disequilibrium, Male, Polymorphism, Single Nucleotide}
}