eprintid: 10064931
rev_number: 16
eprint_status: archive
userid: 608
dir: disk0/10/06/49/31
datestamp: 2019-01-04 12:02:16
lastmod: 2021-12-08 23:56:23
status_changed: 2019-01-04 12:02:16
type: article
metadata_visibility: show
creators_name: Gifford, KA
creators_name: Liu, D
creators_name: Neal, JE
creators_name: Babicz, MA
creators_name: Thompson, JL
creators_name: Walljasper, LE
creators_name: Wiggins, ME
creators_name: Turchan, M
creators_name: Pechman, KR
creators_name: Osborn, KE
creators_name: Acosta, LMY
creators_name: Bell, SP
creators_name: Hohman, TJ
creators_name: Libon, DJ
creators_name: Blennow, K
creators_name: Zetterberg, H
creators_name: Jefferson, AL
title: The 12-Word Philadelphia Verbal Learning Test Performances in Older Adults: Brain MRI and Cerebrospinal Fluid Correlates and Regression-Based Normative Data
ispublished: pub
divisions: UCL
divisions: B02
divisions: C07
divisions: D07
divisions: F86
note: Copyright © 2018 The Author(s) Published by S. Karger AG, Basel.This article is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes as well as any distribution of modified material requires written permission.
abstract: Background/Aims: This study evaluated neuroimaging and biological correlates, psychometric properties, and regression-based normative data of the 12-word Philadelphia Verbal Learning Test (PVLT), a list-learning test. Methods: Vanderbilt Memory and Aging Project participants free of clinical dementia and stroke (n = 230, aged 73 ± 7 years) completed a neuropsychological protocol and brain MRI. A subset (n = 111) underwent lumbar puncture for analysis of Alzheimer's disease (AD) and axonal integrity cerebrospinal fluid (CSF) biomarkers. Regression models related PVLT indices to MRI and CSF biomarkers adjusting for age, sex, race/ethnicity, education, APOE-ϵ4 carrier status, cognitive status, and intracranial volume (MRI models). Secondary analyses were restricted to participants with normal cognition (NC; n = 127), from which regression-based normative data were generated. Results: Lower PVLT performances were associated with smaller medial temporal lobe volumes (p < 0.05) and higher CSF tau concentrations (p < 0.04). Among NC, PVLT indices were associated with white matter hyperintensities on MRI and an axonal injury biomarker (CSF neurofilament light; p < 0.03). Conclusion: The PVLT appears sensitive to markers of neurodegeneration, including temporal regions affected by AD. Conversely, in cognitively normal older adults, PVLT performance seems to relate to white matter disease and axonal injury, perhaps reflecting non-AD pathways to cognitive change. Enhanced normative data enrich the clinical utility of this tool.
date: 2018-12
date_type: published
official_url: http://doi.org/10.1159/000494209
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1616579
doi: 10.1159/000494209
lyricists_name: Zetterberg, Henrik
lyricists_id: HZETT94
actors_name: Bracey, Alan
actors_id: ABBRA90
actors_role: owner
full_text_status: public
publication: Dementia and Geriatric Cognitive Disorders Extra
volume: 8
pagerange: 476-491
issn: 1664-5464
citation:        Gifford, KA;    Liu, D;    Neal, JE;    Babicz, MA;    Thompson, JL;    Walljasper, LE;    Wiggins, ME;                                         ... Jefferson, AL; + view all <#>        Gifford, KA;  Liu, D;  Neal, JE;  Babicz, MA;  Thompson, JL;  Walljasper, LE;  Wiggins, ME;  Turchan, M;  Pechman, KR;  Osborn, KE;  Acosta, LMY;  Bell, SP;  Hohman, TJ;  Libon, DJ;  Blennow, K;  Zetterberg, H;  Jefferson, AL;   - view fewer <#>    (2018)    The 12-Word Philadelphia Verbal Learning Test Performances in Older Adults: Brain MRI and Cerebrospinal Fluid Correlates and Regression-Based Normative Data.                   Dementia and Geriatric Cognitive Disorders Extra , 8    pp. 476-491.    10.1159/000494209 <https://doi.org/10.1159/000494209>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10064931/1/494209.pdf