TY  - JOUR
AV  - public
VL  - 8
SP  - 476
Y1  - 2018/12//
EP  - 491
TI  - The 12-Word Philadelphia Verbal Learning Test Performances in Older Adults: Brain MRI and Cerebrospinal Fluid Correlates and Regression-Based Normative Data
N1  - Copyright © 2018 The Author(s) Published by S. Karger AG, Basel.This article is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes as well as any distribution of modified material requires written permission.
UR  - http://doi.org/10.1159/000494209
SN  - 1664-5464
N2  - Background/Aims: This study evaluated neuroimaging and biological correlates, psychometric properties, and regression-based normative data of the 12-word Philadelphia Verbal Learning Test (PVLT), a list-learning test. Methods: Vanderbilt Memory and Aging Project participants free of clinical dementia and stroke (n = 230, aged 73 ± 7 years) completed a neuropsychological protocol and brain MRI. A subset (n = 111) underwent lumbar puncture for analysis of Alzheimer's disease (AD) and axonal integrity cerebrospinal fluid (CSF) biomarkers. Regression models related PVLT indices to MRI and CSF biomarkers adjusting for age, sex, race/ethnicity, education, APOE-?4 carrier status, cognitive status, and intracranial volume (MRI models). Secondary analyses were restricted to participants with normal cognition (NC; n = 127), from which regression-based normative data were generated. Results: Lower PVLT performances were associated with smaller medial temporal lobe volumes (p < 0.05) and higher CSF tau concentrations (p < 0.04). Among NC, PVLT indices were associated with white matter hyperintensities on MRI and an axonal injury biomarker (CSF neurofilament light; p < 0.03). Conclusion: The PVLT appears sensitive to markers of neurodegeneration, including temporal regions affected by AD. Conversely, in cognitively normal older adults, PVLT performance seems to relate to white matter disease and axonal injury, perhaps reflecting non-AD pathways to cognitive change. Enhanced normative data enrich the clinical utility of this tool.
ID  - discovery10064931
A1  - Gifford, KA
A1  - Liu, D
A1  - Neal, JE
A1  - Babicz, MA
A1  - Thompson, JL
A1  - Walljasper, LE
A1  - Wiggins, ME
A1  - Turchan, M
A1  - Pechman, KR
A1  - Osborn, KE
A1  - Acosta, LMY
A1  - Bell, SP
A1  - Hohman, TJ
A1  - Libon, DJ
A1  - Blennow, K
A1  - Zetterberg, H
A1  - Jefferson, AL
JF  - Dementia and Geriatric Cognitive Disorders Extra
ER  -