eprintid: 10064774
rev_number: 22
eprint_status: archive
userid: 608
dir: disk0/10/06/47/74
datestamp: 2019-01-07 10:22:54
lastmod: 2021-12-05 00:42:37
status_changed: 2019-01-07 10:22:54
type: article
metadata_visibility: show
creators_name: Nemcsik, J
creators_name: Tabák, Á
creators_name: Batta, D
creators_name: Cseprekál, O
creators_name: Egresits, J
creators_name: Tislér, A
title: Integrated central blood pressure-aortic stiffness risk score for cardiovascular risk stratification in chronic kidney disease
ispublished: pub
divisions: UCL
divisions: B02
divisions: D12
divisions: G19
keywords: cardiovascular outcome, central blood pressure, central pulse pressure, chronic kidney disease, pulse wave velocity
note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
abstract: BACKGROUND AND AIMS: The aim of this study was to develop an integrated central blood pressure-aortic stiffness (ICPS) risk score to predict cardiovascular events. METHODS: It was a retrospective cohort study. A total of 100 chronic kidney disease (CKD) patients on conservative therapy were included. Pulse wave velocity (PWV), central systolic blood pressure (cSBP), and central pulse pressure (cPP) were measured. A score was assigned to tertiles of PWV (0-2), cPP (0-2), and cSBP (0 to the first and second and 1 to the third tertile) based on each parameter's ability to individually predict cardiovascular outcome. The sum of these scores and three ICPS risk categories as predictors were studied. Finally, we compared discrimination of the ICPS risk categories with PWV, cSBP, and cPP. RESULTS: Adjusted for age and sex, patients in high and very high ICPS risk categories had increased cardiovascular risk (HR: 3.52, 95% CI: 1.65-7.49; HR: 7.56, 95% CI: 3.20-17.85, respectively). High and very high ICPS risk categories remained independent predictors in a model adjusted for multiple CV risk factors (HR: 4.58, 95% CI: 1.65-7.49; HR: 8.56, 95% CI: 3.09-23.76, respectively). ICPS risk categories (Harrell's C: 0.723, 95% CI: 0.652-0.795) showed better discrimination than PWV (Harrell's C: 0.659, 95% CI: 0.586-0.732, p = 0.028) and cSBP (Harrell's C: 0.660, 95% CI: 0.584-0.735, p = 0.008) and there has been a tendency of significance in case of cPP (Harrell's C: 0.691, 95% CI: 0.621-0.761, p = 0.170). CONCLUSION: The ICPS score may clinically importantly improve the identification of CKD patients with elevated cardiovascular risk.
date: 2018-12
date_type: published
official_url: https://doi.org/10.1556/2060.105.2018.4.29
oa_status: green
full_text_type: other
language: eng
primo: open
primo_central: open_green
article_type_text: Journal Article
verified: verified_manual
elements_id: 1614141
doi: 10.1556/2060.105.2018.4.29
lyricists_name: Tabak, Adam Gyula
lyricists_id: AGTAB08
actors_name: Tabak, Adam Gyula
actors_id: AGTAB08
actors_role: owner
full_text_status: public
publication: Physiology International
volume: 105
number: 4
pagerange: 335-346
event_location: Hungary
issn: 2498-602X
citation:        Nemcsik, J;    Tabák, Á;    Batta, D;    Cseprekál, O;    Egresits, J;    Tislér, A;      (2018)    Integrated central blood pressure-aortic stiffness risk score for cardiovascular risk stratification in chronic kidney disease.                   Physiology International , 105  (4)   pp. 335-346.    10.1556/2060.105.2018.4.29 <https://doi.org/10.1556/2060.105.2018.4.29>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10064774/1/NemcsikJPhysiolInt2018.pdf