TY  - JOUR
EP  - 127
KW  - Biomarkers
KW  -  Fluid-biomarkers
KW  -  Alzheimer?s disease
KW  -  Saliva
KW  -  Tau
KW  -  Diagnosis
KW  -  Immunoassays
A1  - Ashton, NJ
A1  - Ide, M
A1  - Scholl, M
A1  - Blennow, K
A1  - Lovestone, S
A1  - Hye, A
A1  - Zetterberg, H
VL  - 70
TI  - No association of salivary total tau concentration with Alzheimer's disease
Y1  - 2018/10/01/
AV  - public
SP  - 125
N2  - There is a need for an accessible biomarker that can complement current cerebrospinal fluid and imaging biomarkers in an accurate and early diagnosis of Alzheimer disease (AD). Saliva is a rich source of potential biomarkers and proteins related to neurodegenerative disorders have been shown to be present in this matrix, including tau. In this study, we quantified salivary total tau (t-tau) concentration in 160 healthy elderly control, 68 mild cognitive impairment, and 53 AD participants using ultrasensitive Single molecule array (Simoa) technology. No median difference in salivary t-tau concentration was found between AD and mild cognitive impairment or healthy elderly control (12.3 ng/L, 9.8 ng/L and 9.6 ng/L, respectively, p = 0.219). In addition, there was no association of salivary t-tau concentration with neurophysiological assessment or structural magnetic resonance imaging. Despite a nominal increase in AD, due to the large overlaps in concentrations between clinical groups, we conclude that salivary t-tau is a suitable biomarker neither for AD nor for cognitive impairment.
SN  - 1558-1497
PB  - ELSEVIER SCIENCE INC
JF  - Neurobiology of Aging
N1  - This version is the author accepted manuscript. For information on re-use, please refer to the publisher?s terms and conditions.
UR  - http://doi.org/10.1016/j.neurobiolaging.2018.06.014
ID  - discovery10064641
ER  -