eprintid: 10064486 rev_number: 21 eprint_status: archive userid: 608 dir: disk0/10/06/44/86 datestamp: 2018-12-19 15:17:50 lastmod: 2021-09-20 22:22:52 status_changed: 2018-12-19 15:17:50 type: article metadata_visibility: show creators_name: Moore, EE creators_name: Hohman, TJ creators_name: Badami, FS creators_name: Pechman, KR creators_name: Osborn, KE creators_name: Acosta, LMY creators_name: Bell, SP creators_name: Babicz, MA creators_name: Gifford, KA creators_name: Anderson, AW creators_name: Goldstein, LE creators_name: Blennow, K creators_name: Zetterberg, H creators_name: Jefferson, AL title: Neurofilament relates to white matter microstructure in older adults ispublished: pub divisions: UCL divisions: B02 divisions: C07 divisions: D07 divisions: F86 keywords: Neurofilament light, Diffusion tensor imaging, Cerebrospinal fluid, Alzheimer's disease note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. abstract: Cerebrospinal fluid (CSF) neurofilament light (NFL) is a protein biomarker of axonal injury. To study whether NFL is associated with diffusion tensor imaging (DTI) measurements of white matter (WM) microstructure, Vanderbilt Memory & Aging Project participants with normal cognition (n = 77), early mild cognitive impairment (n = 15), and MCI (n = 55) underwent lumbar puncture to obtain CSF and 3T brain MRI. Voxel-wise analyses cross-sectionally related NFL to DTI metrics, adjusting for demographic and vascular risk factors. Increased NFL correlated with multiple DTI metrics (p-values < 0.05). An NFL × diagnosis interaction (excluding early mild cognitive impairment) on WM microstructure (p-values < 0.05) was detected, with associations strongest among MCI. Multiple NFL × CSF biomarker interactions were detected. Associations between NFL and worse WM metrics were strongest among amyloid-β₄₂–negative, tau-positive, and suspected nonamyloid pathology participants. Findings suggest increased NFL, a biomarker of axonal injury, is correlated with compromised WM microstructure. Results highlight the role of elevated NFL in predicting WM damage in cognitively impaired older adults who are amyloid-negative, tau-positive, or meet suspected nonamyloid pathology criteria. date: 2018-10 date_type: published publisher: ELSEVIER SCIENCE INC official_url: https://doi.org/10.1016/j.neurobiolaging.2018.06.023 oa_status: green full_text_type: other language: eng primo: open primo_central: open_green article_type_text: Journal Article verified: verified_manual elements_id: 1571567 doi: 10.1016/j.neurobiolaging.2018.06.023 language_elements: English lyricists_name: Zetterberg, Henrik lyricists_id: HZETT94 actors_name: Zetterberg, Henrik actors_name: Harriot, Anne-Marie actors_id: HZETT94 actors_id: AHARA72 actors_role: owner actors_role: impersonator full_text_status: public publication: Neurobiology of Aging volume: 70 pagerange: 233-241 pages: 9 issn: 0197-4580 citation: Moore, EE; Hohman, TJ; Badami, FS; Pechman, KR; Osborn, KE; Acosta, LMY; Bell, SP; ... Jefferson, AL; + view all <#> Moore, EE; Hohman, TJ; Badami, FS; Pechman, KR; Osborn, KE; Acosta, LMY; Bell, SP; Babicz, MA; Gifford, KA; Anderson, AW; Goldstein, LE; Blennow, K; Zetterberg, H; Jefferson, AL; - view fewer <#> (2018) Neurofilament relates to white matter microstructure in older adults. Neurobiology of Aging , 70 pp. 233-241. 10.1016/j.neurobiolaging.2018.06.023 <https://doi.org/10.1016/j.neurobiolaging.2018.06.023>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10064486/1/Zetterberg_Neurofilament%20relates%20to%20white%20matter%20microstructure%20in%20older%20adults_AAM.pdf