TY  - JOUR
JF  - Neurobiology of Aging
A1  - Moore, EE
A1  - Hohman, TJ
A1  - Badami, FS
A1  - Pechman, KR
A1  - Osborn, KE
A1  - Acosta, LMY
A1  - Bell, SP
A1  - Babicz, MA
A1  - Gifford, KA
A1  - Anderson, AW
A1  - Goldstein, LE
A1  - Blennow, K
A1  - Zetterberg, H
A1  - Jefferson, AL
UR  - https://doi.org/10.1016/j.neurobiolaging.2018.06.023
SN  - 0197-4580
N1  - This version is the author accepted manuscript. For information on re-use, please refer to the publisher?s terms and conditions.
SP  - 233
VL  - 70
KW  - Neurofilament light
KW  -  Diffusion tensor imaging
KW  -  Cerebrospinal fluid
KW  -  Alzheimer's disease
N2  - Cerebrospinal fluid (CSF) neurofilament light (NFL) is a protein biomarker of axonal injury. To study whether NFL is associated with diffusion tensor imaging (DTI) measurements of white matter (WM) microstructure, Vanderbilt Memory & Aging Project participants with normal cognition (n = 77), early mild cognitive impairment (n = 15), and MCI (n = 55) underwent lumbar puncture to obtain CSF and 3T brain MRI. Voxel-wise analyses cross-sectionally related NFL to DTI metrics, adjusting for demographic and vascular risk factors. Increased NFL correlated with multiple DTI metrics (p-values < 0.05). An NFL × diagnosis interaction (excluding early mild cognitive impairment) on WM microstructure (p-values < 0.05) was detected, with associations strongest among MCI. Multiple NFL × CSF biomarker interactions were detected. Associations between NFL and worse WM metrics were strongest among amyloid-????negative, tau-positive, and suspected nonamyloid pathology participants. Findings suggest increased NFL, a biomarker of axonal injury, is correlated with compromised WM microstructure. Results highlight the role of elevated NFL in predicting WM damage in cognitively impaired older adults who are amyloid-negative, tau-positive, or meet suspected nonamyloid pathology criteria.
ID  - discovery10064486
PB  - ELSEVIER SCIENCE INC
TI  - Neurofilament relates to white matter microstructure in older adults
AV  - public
Y1  - 2018/10//
EP  - 241
ER  -