<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> .
<> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery.ucl.ac.uk/id/eprint/10064486> .
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<https://discovery.ucl.ac.uk/id/eprint/10064486> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Article> .
<https://discovery.ucl.ac.uk/id/eprint/10064486> <http://purl.org/dc/terms/title> "Neurofilament relates to white matter microstructure in older adults"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10064486> <http://purl.org/ontology/bibo/abstract> "Cerebrospinal fluid (CSF) neurofilament light (NFL) is a protein biomarker of axonal injury. To study whether NFL is associated with diffusion tensor imaging (DTI) measurements of white matter (WM) microstructure, Vanderbilt Memory & Aging Project participants with normal cognition (n = 77), early mild cognitive impairment (n = 15), and MCI (n = 55) underwent lumbar puncture to obtain CSF and 3T brain MRI. Voxel-wise analyses cross-sectionally related NFL to DTI metrics, adjusting for demographic and vascular risk factors. Increased NFL correlated with multiple DTI metrics (p-values < 0.05). An NFL × diagnosis interaction (excluding early mild cognitive impairment) on WM microstructure (p-values < 0.05) was detected, with associations strongest among MCI. Multiple NFL × CSF biomarker interactions were detected. Associations between NFL and worse WM metrics were strongest among amyloid-β₄₂–negative, tau-positive, and suspected nonamyloid pathology participants. Findings suggest increased NFL, a biomarker of axonal injury, is correlated with compromised WM microstructure. Results highlight the role of elevated NFL in predicting WM damage in cognitively impaired older adults who are amyloid-negative, tau-positive, or meet suspected nonamyloid pathology criteria."^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10064486> <http://purl.org/dc/terms/date> "2018-10" .
<https://discovery.ucl.ac.uk/id/document/808349> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Document> .
<https://discovery.ucl.ac.uk/id/eprint/10064486> <http://purl.org/ontology/bibo/volume> "70" .
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<https://discovery.ucl.ac.uk/id/org/ext-9ab12bce4ed1db8d63802ba79cf39587> <http://xmlns.com/foaf/0.1/name> "ELSEVIER SCIENCE INC"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10064486> <http://purl.org/dc/terms/publisher> <https://discovery.ucl.ac.uk/id/org/ext-9ab12bce4ed1db8d63802ba79cf39587> .
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<https://discovery.ucl.ac.uk/id/publication/ext-01974580> <http://xmlns.com/foaf/0.1/name> "Neurobiology of Aging"^^<http://www.w3.org/2001/XMLSchema#string> .
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<https://discovery.ucl.ac.uk/id/publication/ext-01974580> <http://www.w3.org/2002/07/owl#sameAs> <urn:issn:01974580> .
<https://discovery.ucl.ac.uk/id/publication/ext-01974580> <http://purl.org/ontology/bibo/issn> "01974580" .
<https://discovery.ucl.ac.uk/id/eprint/10064486> <http://purl.org/ontology/bibo/status> <http://purl.org/ontology/bibo/status/published> .
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<https://discovery.ucl.ac.uk/id/eprint/10064486> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10064486#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10064486#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_1> <https://discovery.ucl.ac.uk/id/person/ext-9e404d9d53000677e545d02fa6aed728> .
<https://discovery.ucl.ac.uk/id/eprint/10064486> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-3282e7405eaafd2d14e1f5e77e6a5c24> .
<https://discovery.ucl.ac.uk/id/eprint/10064486> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10064486#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10064486#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_2> <https://discovery.ucl.ac.uk/id/person/ext-3282e7405eaafd2d14e1f5e77e6a5c24> .
<https://discovery.ucl.ac.uk/id/eprint/10064486> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-bcc1651e69b1ebc9b5adc740501b4757> .
<https://discovery.ucl.ac.uk/id/eprint/10064486> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10064486#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10064486#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_3> <https://discovery.ucl.ac.uk/id/person/ext-bcc1651e69b1ebc9b5adc740501b4757> .
<https://discovery.ucl.ac.uk/id/eprint/10064486> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-5d0a4aa49fab28deb5e7b8d628e9cc24> .
<https://discovery.ucl.ac.uk/id/eprint/10064486> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10064486#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10064486#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_4> <https://discovery.ucl.ac.uk/id/person/ext-5d0a4aa49fab28deb5e7b8d628e9cc24> .
<https://discovery.ucl.ac.uk/id/eprint/10064486> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-3c5540e24cb72a180cce76ea774db807> .
<https://discovery.ucl.ac.uk/id/eprint/10064486> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10064486#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10064486#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_5> <https://discovery.ucl.ac.uk/id/person/ext-3c5540e24cb72a180cce76ea774db807> .
<https://discovery.ucl.ac.uk/id/eprint/10064486> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-9df09f43d7fedc583dce49f3cf3e6845> .
<https://discovery.ucl.ac.uk/id/eprint/10064486> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10064486#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10064486#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_6> <https://discovery.ucl.ac.uk/id/person/ext-9df09f43d7fedc583dce49f3cf3e6845> .
<https://discovery.ucl.ac.uk/id/eprint/10064486> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-6dd0174c1b730048a58a9c1a63ab8e84> .
<https://discovery.ucl.ac.uk/id/eprint/10064486> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10064486#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10064486#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_7> <https://discovery.ucl.ac.uk/id/person/ext-6dd0174c1b730048a58a9c1a63ab8e84> .
<https://discovery.ucl.ac.uk/id/eprint/10064486> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-a1c6aaebb6e5f8557efa2d1cb0c5f6c1> .
<https://discovery.ucl.ac.uk/id/eprint/10064486> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10064486#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10064486#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_8> <https://discovery.ucl.ac.uk/id/person/ext-a1c6aaebb6e5f8557efa2d1cb0c5f6c1> .
<https://discovery.ucl.ac.uk/id/eprint/10064486> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-1b6fee6a9661bb64d58c4bc99a7f90b0> .
<https://discovery.ucl.ac.uk/id/eprint/10064486> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10064486#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10064486#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_9> <https://discovery.ucl.ac.uk/id/person/ext-1b6fee6a9661bb64d58c4bc99a7f90b0> .
<https://discovery.ucl.ac.uk/id/eprint/10064486> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-c619fa64dc4e32e0ba11e2217d882908> .
<https://discovery.ucl.ac.uk/id/eprint/10064486> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10064486#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10064486#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_10> <https://discovery.ucl.ac.uk/id/person/ext-c619fa64dc4e32e0ba11e2217d882908> .
<https://discovery.ucl.ac.uk/id/eprint/10064486> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-8c906cf819f0c8ffad4d7aa200bc9ed0> .
<https://discovery.ucl.ac.uk/id/eprint/10064486> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10064486#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10064486#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_11> <https://discovery.ucl.ac.uk/id/person/ext-8c906cf819f0c8ffad4d7aa200bc9ed0> .
<https://discovery.ucl.ac.uk/id/eprint/10064486> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-aa101610ec980b581e64a88567bd6899> .
<https://discovery.ucl.ac.uk/id/eprint/10064486> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10064486#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10064486#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_12> <https://discovery.ucl.ac.uk/id/person/ext-aa101610ec980b581e64a88567bd6899> .
<https://discovery.ucl.ac.uk/id/eprint/10064486> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-b4a67a749c90b2608c956156553377ca> .
<https://discovery.ucl.ac.uk/id/eprint/10064486> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10064486#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10064486#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_13> <https://discovery.ucl.ac.uk/id/person/ext-b4a67a749c90b2608c956156553377ca> .
<https://discovery.ucl.ac.uk/id/eprint/10064486> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-3b6c8b0501d91989fd99320e3b2991f2> .
<https://discovery.ucl.ac.uk/id/eprint/10064486> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10064486#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10064486#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_14> <https://discovery.ucl.ac.uk/id/person/ext-3b6c8b0501d91989fd99320e3b2991f2> .
<https://discovery.ucl.ac.uk/id/person/ext-9e404d9d53000677e545d02fa6aed728> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-9e404d9d53000677e545d02fa6aed728> <http://xmlns.com/foaf/0.1/givenName> "EE"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-9e404d9d53000677e545d02fa6aed728> <http://xmlns.com/foaf/0.1/familyName> "Moore"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-9e404d9d53000677e545d02fa6aed728> <http://xmlns.com/foaf/0.1/name> "EE Moore"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-a1c6aaebb6e5f8557efa2d1cb0c5f6c1> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-a1c6aaebb6e5f8557efa2d1cb0c5f6c1> <http://xmlns.com/foaf/0.1/givenName> "MA"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-a1c6aaebb6e5f8557efa2d1cb0c5f6c1> <http://xmlns.com/foaf/0.1/familyName> "Babicz"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-a1c6aaebb6e5f8557efa2d1cb0c5f6c1> <http://xmlns.com/foaf/0.1/name> "MA Babicz"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-bcc1651e69b1ebc9b5adc740501b4757> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-bcc1651e69b1ebc9b5adc740501b4757> <http://xmlns.com/foaf/0.1/givenName> "FS"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-bcc1651e69b1ebc9b5adc740501b4757> <http://xmlns.com/foaf/0.1/familyName> "Badami"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-bcc1651e69b1ebc9b5adc740501b4757> <http://xmlns.com/foaf/0.1/name> "FS Badami"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-aa101610ec980b581e64a88567bd6899> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-aa101610ec980b581e64a88567bd6899> <http://xmlns.com/foaf/0.1/givenName> "K"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-aa101610ec980b581e64a88567bd6899> <http://xmlns.com/foaf/0.1/familyName> "Blennow"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-aa101610ec980b581e64a88567bd6899> <http://xmlns.com/foaf/0.1/name> "K Blennow"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-9df09f43d7fedc583dce49f3cf3e6845> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-9df09f43d7fedc583dce49f3cf3e6845> <http://xmlns.com/foaf/0.1/givenName> "LMY"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-9df09f43d7fedc583dce49f3cf3e6845> <http://xmlns.com/foaf/0.1/familyName> "Acosta"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-9df09f43d7fedc583dce49f3cf3e6845> <http://xmlns.com/foaf/0.1/name> "LMY Acosta"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-3282e7405eaafd2d14e1f5e77e6a5c24> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-3282e7405eaafd2d14e1f5e77e6a5c24> <http://xmlns.com/foaf/0.1/givenName> "TJ"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-3282e7405eaafd2d14e1f5e77e6a5c24> <http://xmlns.com/foaf/0.1/familyName> "Hohman"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-3282e7405eaafd2d14e1f5e77e6a5c24> <http://xmlns.com/foaf/0.1/name> "TJ Hohman"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-b4a67a749c90b2608c956156553377ca> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-b4a67a749c90b2608c956156553377ca> <http://xmlns.com/foaf/0.1/givenName> "H"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-b4a67a749c90b2608c956156553377ca> <http://xmlns.com/foaf/0.1/familyName> "Zetterberg"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-b4a67a749c90b2608c956156553377ca> <http://xmlns.com/foaf/0.1/name> "H Zetterberg"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-8c906cf819f0c8ffad4d7aa200bc9ed0> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-8c906cf819f0c8ffad4d7aa200bc9ed0> <http://xmlns.com/foaf/0.1/givenName> "LE"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-8c906cf819f0c8ffad4d7aa200bc9ed0> <http://xmlns.com/foaf/0.1/familyName> "Goldstein"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-8c906cf819f0c8ffad4d7aa200bc9ed0> <http://xmlns.com/foaf/0.1/name> "LE Goldstein"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-5d0a4aa49fab28deb5e7b8d628e9cc24> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-5d0a4aa49fab28deb5e7b8d628e9cc24> <http://xmlns.com/foaf/0.1/givenName> "KR"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-5d0a4aa49fab28deb5e7b8d628e9cc24> <http://xmlns.com/foaf/0.1/familyName> "Pechman"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-5d0a4aa49fab28deb5e7b8d628e9cc24> <http://xmlns.com/foaf/0.1/name> "KR Pechman"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-1b6fee6a9661bb64d58c4bc99a7f90b0> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-1b6fee6a9661bb64d58c4bc99a7f90b0> <http://xmlns.com/foaf/0.1/givenName> "KA"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-1b6fee6a9661bb64d58c4bc99a7f90b0> <http://xmlns.com/foaf/0.1/familyName> "Gifford"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-1b6fee6a9661bb64d58c4bc99a7f90b0> <http://xmlns.com/foaf/0.1/name> "KA Gifford"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-c619fa64dc4e32e0ba11e2217d882908> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-c619fa64dc4e32e0ba11e2217d882908> <http://xmlns.com/foaf/0.1/givenName> "AW"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-c619fa64dc4e32e0ba11e2217d882908> <http://xmlns.com/foaf/0.1/familyName> "Anderson"^^<http://www.w3.org/2001/XMLSchema#string> .
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