eprintid: 10063664
rev_number: 23
eprint_status: archive
userid: 608
dir: disk0/10/06/36/64
datestamp: 2018-12-10 09:42:32
lastmod: 2021-10-10 22:30:54
status_changed: 2018-12-10 09:42:32
type: article
metadata_visibility: show
creators_name: Halawa, I
creators_name: Vlachogiannis, P
creators_name: Amandusson, A
creators_name: Elf, K
creators_name: Engstrom, E-R
creators_name: Zetterberg, H
creators_name: Kumlien, E
title: Seizures, CSF neurofilament light and tau in patients with subarachnoid haemorrhage
ispublished: pub
divisions: UCL
divisions: B02
divisions: C07
divisions: D07
divisions: F86
keywords: acute symptomatic seizures, cerebrospinal biomarkers, continuous EEG monitoring, NFL and tau, non-convulsive seizures, subarachnoid haemorrhage
note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
abstract: Objectives:
Patients with severe subarachnoid haemorrhage (SAH) often suffer from complications with delayed cerebral ischaemia (DCI) due to vasospasm that is difficult to identify by clinical examination. The purpose of this study was to monitor seizures and to measure cerebrospinal fluid (CSF) concentrations of neurofilament light (NFL) and tau, and to see whether they could be used for predicting preclinical DCI.

Methods:
We prospectively studied 19 patients with aneurysmal SAH who underwent treatment with endovascular coiling. The patients were monitored with continuous EEG (cEEG) and received external ventricular drainage (EVD). CSF samples of neurofilament light (NLF) and total tau (T‐tau) protein were collected at day 4 and day 10. Cox regression analysis was applied to evaluate whether seizures and protein biomarkers were associated with DCI and poor outcome.

Results:
Seven patients developed DCI (37%), and 4 patients (21%) died within the first 2 months. Six patients (32%) had clinical seizures, and electrographic seizures were noted in one additional patient (4.5%). Increased tau ratio (proportion tau10/tau4) was significantly associated with DCI and hazard ratio [HR=1.33, 95% confidence interval (CI) 1.055‐1.680. P = .016].

Conclusion:
Acute symptomatic seizures are common in SAH, but their presence is not predictive of DCI. High values of the tau ratio in the CSF may be associated with development of DCI.
date: 2018-02
date_type: published
publisher: WILEY
official_url: https://doi.org/10.1111/ane.12873
oa_status: green
full_text_type: other
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1513598
doi: 10.1111/ane.12873
lyricists_name: Zetterberg, Henrik
lyricists_id: HZETT94
actors_name: Jayawardana, Anusha
actors_id: AJAYA51
actors_role: owner
full_text_status: public
publication: Acta Neurologica Scandinavica
volume: 137
number: 2
pagerange: 199-203
pages: 5
issn: 1600-0404
citation:        Halawa, I;    Vlachogiannis, P;    Amandusson, A;    Elf, K;    Engstrom, E-R;    Zetterberg, H;    Kumlien, E;      (2018)    Seizures, CSF neurofilament light and tau in patients with subarachnoid haemorrhage.                   Acta Neurologica Scandinavica , 137  (2)   pp. 199-203.    10.1111/ane.12873 <https://doi.org/10.1111/ane.12873>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10063664/1/Zetterberg_Halawa.pdf