eprintid: 10063559 rev_number: 20 eprint_status: archive userid: 608 dir: disk0/10/06/35/59 datestamp: 2018-12-10 14:31:55 lastmod: 2021-12-10 23:46:09 status_changed: 2018-12-10 14:31:55 type: article metadata_visibility: show creators_name: Poduval, R creators_name: Coote, J creators_name: Mosse, C creators_name: Finlay, M creators_name: Papakonstantinou, I creators_name: Desjardins, A title: 3D printed micro-scale fiber optic probe for intravascular pressure sensing ispublished: pub divisions: UCL divisions: B04 divisions: C05 divisions: F43 divisions: F46 divisions: F42 note: This version is the version of the record. For information on re-use, please refer to the publisher’s terms and conditions. abstract: Small form-factor invasive pressure sensors are widely used in minimally invasive surgery, for example to guide decision making in coronary stenting procedures. Current fiber-optic sensors can have high manufacturing complexities and costs, which severely constrains their adoption outside of niche fields. A particular challenge is the ability to rapidly prototype and iterate upon sensor designs to optimize performance for different applications and medical devices. Here, we present a new sensor fabrication method, which involves two-photon polymerization printing and integration of the printed structure onto the end-face of a single-mode optical fiber. The active elements of the sensor were a pressure-sensitive diaphragm and an intermediate temperature-sensitive spacer that was insensitive to changes in external pressure. Deflection of the diaphragm and thermal expansion the spacer relative to the fiber end-face were monitored using phase-resolved low coherence interferometry. A pressure sensitivity of 0.031 rad/mmHg across the range of 760 to 1060 mmHg (absolute pressure), and a temperature sensitivity of 1.2 mrad/°C across the range 20 to 45°C were observed. This method will enable the fabrication of a wide range of fiber-optic sensors with pressure and temperature sensitivities suitable for guiding minimally invasive surgery. date: 2018-09-05 date_type: published official_url: https://doi.org/10.1117/12.2321980 oa_status: green full_text_type: pub language: eng primo: open primo_central: open_green verified: verified_manual elements_id: 1606796 doi: 10.1117/12.2321980 lyricists_name: Coote, Joanna lyricists_name: Desjardins, Adrien lyricists_name: Papakonstantinou, Ioannis lyricists_name: Poduval, Radhika lyricists_id: JCOOT01 lyricists_id: AEDES16 lyricists_id: IPAPA54 lyricists_id: RPODU23 actors_name: Poduval, Radhika actors_id: RPODU23 actors_role: owner full_text_status: public publication: Proceedings of Biosensing and Nanomedicine XI volume: 10728 article_number: 107280B (2018) issn: 0277-786X citation: Poduval, R; Coote, J; Mosse, C; Finlay, M; Papakonstantinou, I; Desjardins, A; (2018) 3D printed micro-scale fiber optic probe for intravascular pressure sensing. Proceedings of Biosensing and Nanomedicine XI , 10728 , Article 107280B (2018). 10.1117/12.2321980 <https://doi.org/10.1117/12.2321980>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10063559/1/107280B%281%29.pdf