TY - JOUR SN - 0277-786X UR - https://doi.org/10.1117/12.2321980 ID - discovery10063559 N2 - Small form-factor invasive pressure sensors are widely used in minimally invasive surgery, for example to guide decision making in coronary stenting procedures. Current fiber-optic sensors can have high manufacturing complexities and costs, which severely constrains their adoption outside of niche fields. A particular challenge is the ability to rapidly prototype and iterate upon sensor designs to optimize performance for different applications and medical devices. Here, we present a new sensor fabrication method, which involves two-photon polymerization printing and integration of the printed structure onto the end-face of a single-mode optical fiber. The active elements of the sensor were a pressure-sensitive diaphragm and an intermediate temperature-sensitive spacer that was insensitive to changes in external pressure. Deflection of the diaphragm and thermal expansion the spacer relative to the fiber end-face were monitored using phase-resolved low coherence interferometry. A pressure sensitivity of 0.031 rad/mmHg across the range of 760 to 1060 mmHg (absolute pressure), and a temperature sensitivity of 1.2 mrad/°C across the range 20 to 45°C were observed. This method will enable the fabrication of a wide range of fiber-optic sensors with pressure and temperature sensitivities suitable for guiding minimally invasive surgery. A1 - Poduval, R A1 - Coote, J A1 - Mosse, C A1 - Finlay, M A1 - Papakonstantinou, I A1 - Desjardins, A JF - Proceedings of Biosensing and Nanomedicine XI AV - public Y1 - 2018/09/05/ VL - 10728 TI - 3D printed micro-scale fiber optic probe for intravascular pressure sensing N1 - This version is the version of the record. For information on re-use, please refer to the publisher?s terms and conditions. ER -