eprintid: 10063531
rev_number: 16
eprint_status: archive
userid: 608
dir: disk0/10/06/35/31
datestamp: 2018-12-07 14:51:37
lastmod: 2021-09-25 23:25:45
status_changed: 2018-12-07 14:51:37
type: article
metadata_visibility: show
creators_name: Kekic, M
creators_name: McClelland, J
creators_name: Bartholdy, S
creators_name: Boysen, E
creators_name: Musiat, P
creators_name: Dalton, B
creators_name: Tiza, M
creators_name: David, AS
creators_name: Campbell, IC
creators_name: Schmidt, U
title: Single-Session Transcranial Direct Current Stimulation Temporarily Improves Symptoms, Mood, and Self-Regulatory Control in Bulimia Nervosa: A Randomised Controlled Trial
ispublished: pub
divisions: UCL
divisions: B02
divisions: C07
divisions: D79
note: © 2017 Kekic et al. This is an open
access article distributed under the terms of the
Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which
permits unrestricted use, distribution, and
reproduction in any medium, provided the original
author and source are credited.
abstract: BACKGROUND: 
Evidence suggests that pathological eating behaviours in bulimia nervosa (BN) are underpinned by alterations in reward processing and self-regulatory control, and by functional changes in neurocircuitry encompassing the dorsolateral prefrontal cortex (DLPFC). Manipulation of this region with transcranial direct current stimulation (tDCS) may therefore alleviate symptoms of the disorder.

OBJECTIVE:
This double-blind sham-controlled proof-of-principle trial investigated the effects of bilateral tDCS over the DLPFC in adults with BN.

METHODS:
Thirty-nine participants (two males) received three sessions of tDCS in a randomised and counterbalanced order: anode right/cathode left (AR/CL), anode left/cathode right (AL/CR), and sham. A battery of psychological/neurocognitive measures was completed before and after each session and the frequency of bulimic behaviours during the following 24-hours was recorded.

RESULTS: 
AR/CL tDCS reduced eating disorder cognitions (indexed by the Mizes Eating Disorder Cognitions Questionnaire-Revised) when compared to AL/CR and sham tDCS. Both active conditions suppressed the self-reported urge to binge-eat and increased self-regulatory control during a temporal discounting task. Compared to sham stimulation, mood (assessed with the Profile of Mood States) improved after AR/CL but not AL/CR tDCS. Lastly, the three tDCS sessions had comparable effects on the wanting/liking of food and on bulimic behaviours during the 24 hours post-stimulation.

CONCLUSIONS: 
These data suggest that single-session tDCS transiently improves symptoms of BN. They also help to elucidate possible mechanisms of action and highlight the importance of selecting the optimal electrode montage. Multi-session trials are needed to determine whether tDCS has potential for development as a treatment for adult BN.
date: 2017-01
date_type: published
publisher: PUBLIC LIBRARY SCIENCE
official_url: https://doi.org/10.1371/journal.pone.0167606
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
article_type_text: Article
verified: verified_manual
elements_id: 1594932
doi: 10.1371/journal.pone.0167606
language_elements: English
lyricists_name: David, Anthony
lyricists_id: ADDAV87
actors_name: Cuccu, Clara
actors_id: CCCUC40
actors_role: owner
full_text_status: public
publication: PLoS One
volume: 12
number: 1
article_number: e0167606
pages: 17
issn: 1932-6203
citation:        Kekic, M;    McClelland, J;    Bartholdy, S;    Boysen, E;    Musiat, P;    Dalton, B;    Tiza, M;             ... Schmidt, U; + view all <#>        Kekic, M;  McClelland, J;  Bartholdy, S;  Boysen, E;  Musiat, P;  Dalton, B;  Tiza, M;  David, AS;  Campbell, IC;  Schmidt, U;   - view fewer <#>    (2017)    Single-Session Transcranial Direct Current Stimulation Temporarily Improves Symptoms, Mood, and Self-Regulatory Control in Bulimia Nervosa: A Randomised Controlled Trial.                   PLoS One , 12  (1)    , Article e0167606.  10.1371/journal.pone.0167606 <https://doi.org/10.1371/journal.pone.0167606>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10063531/1/Kekic_journal.pone.0167606.pdf