eprintid: 10063531 rev_number: 16 eprint_status: archive userid: 608 dir: disk0/10/06/35/31 datestamp: 2018-12-07 14:51:37 lastmod: 2021-09-25 23:25:45 status_changed: 2018-12-07 14:51:37 type: article metadata_visibility: show creators_name: Kekic, M creators_name: McClelland, J creators_name: Bartholdy, S creators_name: Boysen, E creators_name: Musiat, P creators_name: Dalton, B creators_name: Tiza, M creators_name: David, AS creators_name: Campbell, IC creators_name: Schmidt, U title: Single-Session Transcranial Direct Current Stimulation Temporarily Improves Symptoms, Mood, and Self-Regulatory Control in Bulimia Nervosa: A Randomised Controlled Trial ispublished: pub divisions: UCL divisions: B02 divisions: C07 divisions: D79 note: © 2017 Kekic et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. abstract: BACKGROUND: Evidence suggests that pathological eating behaviours in bulimia nervosa (BN) are underpinned by alterations in reward processing and self-regulatory control, and by functional changes in neurocircuitry encompassing the dorsolateral prefrontal cortex (DLPFC). Manipulation of this region with transcranial direct current stimulation (tDCS) may therefore alleviate symptoms of the disorder. OBJECTIVE: This double-blind sham-controlled proof-of-principle trial investigated the effects of bilateral tDCS over the DLPFC in adults with BN. METHODS: Thirty-nine participants (two males) received three sessions of tDCS in a randomised and counterbalanced order: anode right/cathode left (AR/CL), anode left/cathode right (AL/CR), and sham. A battery of psychological/neurocognitive measures was completed before and after each session and the frequency of bulimic behaviours during the following 24-hours was recorded. RESULTS: AR/CL tDCS reduced eating disorder cognitions (indexed by the Mizes Eating Disorder Cognitions Questionnaire-Revised) when compared to AL/CR and sham tDCS. Both active conditions suppressed the self-reported urge to binge-eat and increased self-regulatory control during a temporal discounting task. Compared to sham stimulation, mood (assessed with the Profile of Mood States) improved after AR/CL but not AL/CR tDCS. Lastly, the three tDCS sessions had comparable effects on the wanting/liking of food and on bulimic behaviours during the 24 hours post-stimulation. CONCLUSIONS: These data suggest that single-session tDCS transiently improves symptoms of BN. They also help to elucidate possible mechanisms of action and highlight the importance of selecting the optimal electrode montage. Multi-session trials are needed to determine whether tDCS has potential for development as a treatment for adult BN. date: 2017-01 date_type: published publisher: PUBLIC LIBRARY SCIENCE official_url: https://doi.org/10.1371/journal.pone.0167606 oa_status: green full_text_type: pub language: eng primo: open primo_central: open_green article_type_text: Article verified: verified_manual elements_id: 1594932 doi: 10.1371/journal.pone.0167606 language_elements: English lyricists_name: David, Anthony lyricists_id: ADDAV87 actors_name: Cuccu, Clara actors_id: CCCUC40 actors_role: owner full_text_status: public publication: PLoS One volume: 12 number: 1 article_number: e0167606 pages: 17 issn: 1932-6203 citation: Kekic, M; McClelland, J; Bartholdy, S; Boysen, E; Musiat, P; Dalton, B; Tiza, M; ... Schmidt, U; + view all <#> Kekic, M; McClelland, J; Bartholdy, S; Boysen, E; Musiat, P; Dalton, B; Tiza, M; David, AS; Campbell, IC; Schmidt, U; - view fewer <#> (2017) Single-Session Transcranial Direct Current Stimulation Temporarily Improves Symptoms, Mood, and Self-Regulatory Control in Bulimia Nervosa: A Randomised Controlled Trial. PLoS One , 12 (1) , Article e0167606. 10.1371/journal.pone.0167606 <https://doi.org/10.1371/journal.pone.0167606>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10063531/1/Kekic_journal.pone.0167606.pdf