eprintid: 10062956 rev_number: 31 eprint_status: archive userid: 608 dir: disk0/10/06/29/56 datestamp: 2018-12-04 12:19:02 lastmod: 2021-12-22 22:29:56 status_changed: 2019-01-28 12:36:24 type: article metadata_visibility: show creators_name: Tsui, A creators_name: Richards, M creators_name: Davis, DHJ title: Systemic inflammation and modifiable risk factors for cognitive impairment in older persons: Findings from a British birth cohort ispublished: pub divisions: UCL divisions: B02 divisions: D14 divisions: GA3 divisions: G17 note: © 2018 The Authors. This is an open access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). abstract: Serum pro‐inflammatory markers may contribute to dementia pathophysiology and cognitive impairment. In a population‐representative birth cohort, serum C‐reactive protein (CRP), interleukin‐6 (IL‐6), and white cell count (WCC) were measured at age 60‐64 years and cognition was assessed using the Addenbrooke's Cognitive Examination (ACE‐III) at age 69 years. Higher baseline CRP and IL‐6 were associated with lower ACE‐III scores, but associations were attenuated on adjustment for educational attainment, sex, and other modifiable life course factors. No associations were found for CRP, IL‐6, and WCC with visual search speed or verbal memory. In conclusion, the relationship between increased baseline systemic inflammation and poorer cognition in later life may be explained by, or share pathways with, education and other modifiable life course factors. date: 2018-12 date_type: published official_url: https://doi.org/10.1002/agm2.12044 oa_status: green full_text_type: pub language: eng primo: open primo_central: open_green article_type_text: Journal Article verified: verified_manual elements_id: 1605809 doi: 10.1002/agm2.12044 language_elements: English lyricists_name: Davis, Daniel lyricists_name: Richards, Marcus lyricists_name: Tsui, Alex lyricists_id: DDAVI19 lyricists_id: MRICH78 lyricists_id: ATSUI01 actors_name: Davis, Daniel actors_id: DDAVI19 actors_role: owner full_text_status: public publication: Aging Medicine volume: 1 number: 3 pagerange: 243-248 issn: 2475-0360 citation: Tsui, A; Richards, M; Davis, DHJ; (2018) Systemic inflammation and modifiable risk factors for cognitive impairment in older persons: Findings from a British birth cohort. Aging Medicine , 1 (3) pp. 243-248. 10.1002/agm2.12044 <https://doi.org/10.1002/agm2.12044>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10062956/1/Tsui_Systemic%20inflammation%20and%20modifiable%20risk%20factors%20for%20cognitive%20impairment%20in%20older%20persons.%20Findings%20from%20a%20British%20birth%20cohort_VoR.pdf