eprintid: 10062956
rev_number: 31
eprint_status: archive
userid: 608
dir: disk0/10/06/29/56
datestamp: 2018-12-04 12:19:02
lastmod: 2021-12-22 22:29:56
status_changed: 2019-01-28 12:36:24
type: article
metadata_visibility: show
creators_name: Tsui, A
creators_name: Richards, M
creators_name: Davis, DHJ
title: Systemic inflammation and modifiable risk factors for cognitive impairment in older persons: Findings from a British birth cohort
ispublished: pub
divisions: UCL
divisions: B02
divisions: D14
divisions: GA3
divisions: G17
note: © 2018 The Authors. This is an open access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/).
abstract: Serum pro‐inflammatory markers may contribute to dementia pathophysiology and cognitive impairment. In a population‐representative birth cohort, serum C‐reactive protein (CRP), interleukin‐6 (IL‐6), and white cell count (WCC) were measured at age 60‐64 years and cognition was assessed using the Addenbrooke's Cognitive Examination (ACE‐III) at age 69 years. Higher baseline CRP and IL‐6 were associated with lower ACE‐III scores, but associations were attenuated on adjustment for educational attainment, sex, and other modifiable life course factors. No associations were found for CRP, IL‐6, and WCC with visual search speed or verbal memory. In conclusion, the relationship between increased baseline systemic inflammation and poorer cognition in later life may be explained by, or share pathways with, education and other modifiable life course factors.
date: 2018-12
date_type: published
official_url: https://doi.org/10.1002/agm2.12044
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
article_type_text: Journal Article
verified: verified_manual
elements_id: 1605809
doi: 10.1002/agm2.12044
language_elements: English
lyricists_name: Davis, Daniel
lyricists_name: Richards, Marcus
lyricists_name: Tsui, Alex
lyricists_id: DDAVI19
lyricists_id: MRICH78
lyricists_id: ATSUI01
actors_name: Davis, Daniel
actors_id: DDAVI19
actors_role: owner
full_text_status: public
publication: Aging Medicine
volume: 1
number: 3
pagerange: 243-248
issn: 2475-0360
citation:        Tsui, A;    Richards, M;    Davis, DHJ;      (2018)    Systemic inflammation and modifiable risk factors for cognitive impairment in older persons: Findings from a British birth cohort.                   Aging Medicine , 1  (3)   pp. 243-248.    10.1002/agm2.12044 <https://doi.org/10.1002/agm2.12044>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10062956/1/Tsui_Systemic%20inflammation%20and%20modifiable%20risk%20factors%20for%20cognitive%20impairment%20in%20older%20persons.%20Findings%20from%20a%20British%20birth%20cohort_VoR.pdf