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<https://discovery.ucl.ac.uk/id/eprint/10062685> <http://purl.org/dc/terms/title> "Cerebellar-M1 Connectivity Changes Associated with Motor Learning Are Somatotopic Specific"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10062685> <http://purl.org/ontology/bibo/abstract> "One ofthefunctions ofthe cerebellum in motor learning isto predict and accountfor systematic changestothe body or environment. This\r\nform of adaptive learning is mediated by plastic changes occurring within the cerebellar cortex. The strength of cerebellar-to-cerebral\r\npathways for a given muscle may reflect aspects of cerebellum-dependent motor adaptation. These connections with motor cortex (M1)\r\ncan be estimated as cerebellar inhibition (CBI): a conditioning pulse of transcranial magnetic stimulation delivered to the cerebellum\r\nbefore a test pulse over motor cortex. Previously, we have demonstrated that changes in CBI for a given muscle representation correlate\r\nwith learning a motor adaptation task with the involved limb. However, the specificity of these effects is unknown. Here, we investigated\r\nwhether CBI changes in humans are somatotopy specific and how they relate to motor adaptation. We found that learning a visuomotor\r\nrotation task with the right hand changed CBI, not only for the involved first dorsal interosseous of the right hand, but also for an\r\nuninvolved right leg muscle, the tibialis anterior, likely related to inter-effector transfer of learning. In two follow-up experiments, we\r\ninvestigated whether the preparation of a simple hand or leg movement would produce a somatotopy-specific modulation of CBI. We\r\nfound that CBI changes only for the effector involved in the movement. These results indicate that learning-related changes in cerebellar–M1\r\nconnectivity reflect a somatotopy-specific interaction. Modulation of this pathway is also present in the context of interlimb\r\ntransfer of learning."^^<http://www.w3.org/2001/XMLSchema#string> .
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