%X Background Among adults with schizophrenia, evidence suggests that premorbid deficits in different cognitive domains follow distinct developmental courses during childhood and adolescence. The aim of this study was to delineate trajectories of adolescent cognitive functions prospectively among different groups of youth atâ€risk for schizophrenia, relative to their typically developing (TD) peers. Method Using linear mixed models adjusted for sex, ethnicity, parental occupation and practice effects, cognitive development between ages 9 and 16 years was compared for youth characterised by a triad of wellâ€replicated developmental antecedents of schizophrenia (ASz; N = 32) and youth with a least one affected relative with schizophrenia or schizoaffective disorder (FHx; N = 29), relative to TD youth (N = 45). Participants completed measures of IQ, scholastic achievement, memory and executive function at three timeâ€points, separated by approximately 24â€month intervals. Results Compared to TD youth, both ASz and FHx youth displayed stable developmental deficits in verbal working memory and inhibition/switching executive functions. ASz youth additionally presented with stable deficits in measures of vocabulary (IQ), word reading, numerical operations, and category fluency executive function, and a slower rate of growth (developmental lag) on spelling from 9 to 16 years than TD peers. Conversely, faster rates of growth relative to TD peers (developmental delay) were observed on visual and verbal memory, and on category fluency executive function (ASz youth only) and on matrix reasoning (IQ) and word reading (FHx youth only). Conclusions These differential patterns of deviation from normative adolescent cognitive development among atâ€risk youth imply potential for cognitive rehabilitation targeting of specific cognitive deficits at different developmental phases. %K Social Sciences, Science & Technology, Life Sciences & Biomedicine, Psychology, Developmental, Psychiatry, Psychology, Psychosis, intelligence, academic performance, memory, executive function, CLINICAL HIGH-RISK, AGED 9-12 YEARS, NEUROCOGNITIVE PERFORMANCE, PSYCHIATRIC-DISORDERS, PUTATIVE ANTECEDENTS, ADULT SCHIZOPHRENIA, PSYCHOSIS, CHILDREN, COHORT, EXPERIENCES %I WILEY %T Trajectories of cognitive development during adolescence among youth at-risk for schizophrenia %L discovery10062605 %P 1215-1224 %V 59 %A H Dickson %A AE Cullen %A R Jones %A A Reichenberg %A RE Roberts %A S Hodgins %A RG Morris %A KR Laurens %J Journal of Child Psychology and Psychiatry %N 11 %D 2018 %O This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/