eprintid: 10062506
rev_number: 29
eprint_status: archive
userid: 608
dir: disk0/10/06/25/06
datestamp: 2018-11-28 17:56:01
lastmod: 2021-11-01 01:45:43
status_changed: 2018-11-28 17:56:01
type: article
metadata_visibility: show
creators_name: Raina, R
creators_name: Lam, S
creators_name: Raheja, H
creators_name: Krishnappa, V
creators_name: Hothi, D
creators_name: Davenport, A
creators_name: Chand, D
creators_name: Kapur, G
creators_name: Schaefer, F
creators_name: Kumar Sethi, S
creators_name: McCulloch, M
creators_name: Bagga, A
creators_name: Bunchman, T
creators_name: Warady, B
title: Pediatric Intradialytic Hypotension: Recommendations From the Pediatric Continuous Renal Replacement Therapy (PCRRT) Workgroup
ispublished: pub
subjects: GOSH
subjects: RFH
divisions: UCL
divisions: B02
divisions: C10
divisions: D17
keywords: Intradialytic hypotension, children, blood pressure monitoring, sodium profiling, blood
volume monitoring, dialysate cooling, mannitol, midodrine
note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
abstract: Intradialytic hypotension (IDH) is a common adverse event resulting in premature
interruption of hemodialysis, and consequently, inadequate fluid and solute removal. IDH
occurs in response to the reduction in blood volume during ultrafiltration and subsequent
poor compensatory mechanisms due to abnormal cardiac function or autonomic or
baroreceptor failure. Pediatric patients are inherently at risk for IDH due to the added
difficulty of determining and attaining an accurate dry weight. While frequent blood pressure
monitoring, dialysate sodium profiling, ultrafiltration guided blood volume monitoring,
dialysate cooling, hemodiafiltration, and intradialytic mannitol and midodrine have been
used to prevent IDH, they have not been extensively studied in pediatric population. Lack of
large-scale studies on IDH in children makes it difficult to develop evidence based
management guidelines. Here we aim to review IDH preventative strategies in the pediatric
population and outlay recommendations from the Pediatric Continuous Renal Replacement
Therapy (PCRRT) Workgroup. Without strong evidence in the literature, our
recommendations from the expert panel reflect expert opinion and serves as a valuable
guide.
date: 2019-05
date_type: published
publisher: Springer Verlag
official_url: https://doi.org/10.1007/s00467-018-4190-1
oa_status: green
full_text_type: other
language: eng
primo: open
primo_central: open_green
article_type_text: Article
verified: verified_manual
elements_id: 1605084
doi: 10.1007/s00467-018-4190-1
lyricists_name: Davenport, Andrew
lyricists_id: ADAVE78
actors_name: Waragoda Vitharana, Nimal
actors_id: NWARR44
actors_role: owner
full_text_status: public
publication: Pediatric Nephrology
volume: 34
number: 5
pagerange: 925-941
issn: 0931-041X
citation:        Raina, R;    Lam, S;    Raheja, H;    Krishnappa, V;    Hothi, D;    Davenport, A;    Chand, D;                             ... Warady, B; + view all <#>        Raina, R;  Lam, S;  Raheja, H;  Krishnappa, V;  Hothi, D;  Davenport, A;  Chand, D;  Kapur, G;  Schaefer, F;  Kumar Sethi, S;  McCulloch, M;  Bagga, A;  Bunchman, T;  Warady, B;   - view fewer <#>    (2019)    Pediatric Intradialytic Hypotension: Recommendations From the Pediatric Continuous Renal Replacement Therapy (PCRRT) Workgroup.                   Pediatric Nephrology , 34  (5)   pp. 925-941.    10.1007/s00467-018-4190-1 <https://doi.org/10.1007/s00467-018-4190-1>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10062506/1/Davenport_Pediatric%20Intradialytic%20Hypotension.pdf