@article{discovery10062506,
           pages = {925--941},
          volume = {34},
            note = {This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.},
           title = {Pediatric Intradialytic Hypotension: Recommendations From the Pediatric Continuous Renal Replacement Therapy (PCRRT) Workgroup},
            year = {2019},
       publisher = {Springer Verlag},
         journal = {Pediatric Nephrology},
           month = {May},
          number = {5},
        abstract = {Intradialytic hypotension (IDH) is a common adverse event resulting in premature
interruption of hemodialysis, and consequently, inadequate fluid and solute removal. IDH
occurs in response to the reduction in blood volume during ultrafiltration and subsequent
poor compensatory mechanisms due to abnormal cardiac function or autonomic or
baroreceptor failure. Pediatric patients are inherently at risk for IDH due to the added
difficulty of determining and attaining an accurate dry weight. While frequent blood pressure
monitoring, dialysate sodium profiling, ultrafiltration guided blood volume monitoring,
dialysate cooling, hemodiafiltration, and intradialytic mannitol and midodrine have been
used to prevent IDH, they have not been extensively studied in pediatric population. Lack of
large-scale studies on IDH in children makes it difficult to develop evidence based
management guidelines. Here we aim to review IDH preventative strategies in the pediatric
population and outlay recommendations from the Pediatric Continuous Renal Replacement
Therapy (PCRRT) Workgroup. Without strong evidence in the literature, our
recommendations from the expert panel reflect expert opinion and serves as a valuable
guide.},
            issn = {0931-041X},
          author = {Raina, R and Lam, S and Raheja, H and Krishnappa, V and Hothi, D and Davenport, A and Chand, D and Kapur, G and Schaefer, F and Kumar Sethi, S and McCulloch, M and Bagga, A and Bunchman, T and Warady, B},
             url = {https://doi.org/10.1007/s00467-018-4190-1},
        keywords = {Intradialytic hypotension, children, blood pressure monitoring, sodium profiling, blood
volume monitoring, dialysate cooling, mannitol, midodrine}
}