eprintid: 10061982 rev_number: 26 eprint_status: archive userid: 608 dir: disk0/10/06/19/82 datestamp: 2018-11-22 16:46:46 lastmod: 2021-10-03 23:56:14 status_changed: 2018-11-22 16:46:46 type: article metadata_visibility: show creators_name: Hardy, CJD creators_name: Bond, RL creators_name: Jaisin, K creators_name: Marshall, CR creators_name: Russell, LL creators_name: Dick, K creators_name: Crutch, SJ creators_name: Rohrer, JD creators_name: Warren, JD title: Sensitivity of Speech Output to Delayed Auditory Feedback in Primary Progressive Aphasias ispublished: pub divisions: UCL divisions: B02 divisions: C07 divisions: D07 divisions: F86 keywords: delayed auditory feedback, primary progressive aphasia, semantic dementia, logopenic aphasia, Alzheimer's disease, frontotemporal dementia, dementia, progressive nonfluent aphasia note: Copyright © 2018 Hardy, Bond, Jaisin, Marshall, Russell, Dick, Crutch, Rohrer and Warren. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (http://creativecommons.org/licenses/by/4.0/). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. abstract: Delayed auditory feedback (DAF) is a classical paradigm for probing sensori-motor interactions in speech output and has been studied in various disorders associated with speech dysfluency and aphasia. However, little information is available concerning the effects of DAF on degenerating language networks in primary progressive aphasia: the paradigmatic “language-led dementias.” Here we studied two forms of speech output (reading aloud and propositional speech) under natural listening conditions (no feedback delay) and under DAF at 200 ms, in a cohort of 19 patients representing all major primary progressive aphasia syndromes vs. healthy older individuals and patients with other canonical dementia syndromes (typical Alzheimer's disease and behavioral variant frontotemporal dementia). Healthy controls and most syndromic groups showed a quantitatively or qualitatively similar profile of reduced speech output rate and increased speech error rate under DAF relative to natural auditory feedback. However, there was no group effect on propositional speech output rate under DAF in patients with nonfluent primary progressive aphasia and logopenic aphasia. Importantly, there was considerable individual variation in DAF sensitivity within syndromic groups and some patients in each group (though no healthy controls) apparently benefited from DAF, showing paradoxically increased speech output rate and/or reduced speech error rate under DAF. This work suggests that DAF may be an informative probe of pathophysiological mechanisms underpinning primary progressive aphasia: identification of “DAF responders” may open up an avenue to novel therapeutic applications. date: 2018-10-29 date_type: published publisher: FRONTIERS MEDIA SA official_url: https://doi.org/10.3389/fneur.2018.00894 oa_status: green full_text_type: pub language: eng primo: open primo_central: open_green verified: verified_manual elements_id: 1601578 doi: 10.3389/fneur.2018.00894 lyricists_name: Bond, Rebecca lyricists_name: Crutch, Sebastian lyricists_name: Hardy, Christopher lyricists_name: Marshall, Charles lyricists_name: Moore, Katrina lyricists_name: Rohrer, Jonathan lyricists_name: Russell, Lucy lyricists_name: Warren, Jason lyricists_id: RLBON31 lyricists_id: SJCRU02 lyricists_id: HARDY72 lyricists_id: CRMAR37 lyricists_id: KDICK46 lyricists_id: JDROH34 lyricists_id: LLRUS40 lyricists_id: JDWAR75 actors_name: Cuccu, Clara actors_id: CCCUC40 actors_role: owner full_text_status: public publication: Frontiers in Neurology volume: 9 article_number: 894 pages: 11 issn: 1664-2295 citation: Hardy, CJD; Bond, RL; Jaisin, K; Marshall, CR; Russell, LL; Dick, K; Crutch, SJ; ... Warren, JD; + view all <#> Hardy, CJD; Bond, RL; Jaisin, K; Marshall, CR; Russell, LL; Dick, K; Crutch, SJ; Rohrer, JD; Warren, JD; - view fewer <#> (2018) Sensitivity of Speech Output to Delayed Auditory Feedback in Primary Progressive Aphasias. Frontiers in Neurology , 9 , Article 894. 10.3389/fneur.2018.00894 <https://doi.org/10.3389/fneur.2018.00894>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10061982/1/Hardy_fneur-09-00894.pdf