eprintid: 10061481
rev_number: 24
eprint_status: archive
userid: 608
dir: disk0/10/06/14/81
datestamp: 2018-11-15 15:32:53
lastmod: 2021-12-10 01:04:45
status_changed: 2018-11-15 15:32:53
type: article
metadata_visibility: show
creators_name: Muthuri, SG
creators_name: Pavlova, AV
creators_name: Saunders, FR
creators_name: Hardy, RJ
creators_name: Gregory, JS
creators_name: Barr, RJ
creators_name: Martin, KR
creators_name: Adams, JE
creators_name: Kuh, D
creators_name: Aspden, RM
creators_name: Cooper, R
title: Associations between back pain across adulthood and spine shape in early old age in a British birth cohort
ispublished: pub
divisions: UCL
divisions: B16
divisions: B14
divisions: J81
divisions: B02
divisions: D14
note: This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
abstract: We aimed to examine whether back pain across adulthood was associated with spine shape at age 60-64 years. Data were from 1405 participants in the MRC National Survey of Health and Development, a nationally representative British birth cohort. Back pain was ascertained during nurse interviews at ages 36, 43, 53 and 60-64 years. Cumulative exposure to back pain was then derived by counting the number of ages at which back pain was reported. Statistical shape modelling was used to characterise thoracolumbar spine shape using lateral dual-energy x-ray absorptiometry images which were ascertained at age 60-64 years. Linear regression models were used to test associations of spine shape modes (SM) with: (1) cumulative exposure to back pain; (2) back pain reports during different periods of adulthood. After adjusting for sex, higher cumulative exposure to back pain across adulthood was associated with wedge-shaped L4-5 disc (lower SM4 scores) and smaller disc spaces (higher SM8 scores) in both sexes. In addition, reporting of back pain at ages 53 and/or 60-64 years was associated with smaller L4-5 disc space (lower SM6 scores) in men but not women. These findings suggest that back pain across adulthood may be associated with specific variations in spine shapes in early old age.
date: 2018-11-05
date_type: published
official_url: https://doi.org/10.1038/s41598-018-34628-9
oa_status: green
full_text_type: pub
pmcid: PMC6218503
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1601004
doi: 10.1038/s41598-018-34628-9
pii: 10.1038/s41598-018-34628-9
lyricists_name: Cooper, Rachel
lyricists_name: Hardy, Rebecca
lyricists_name: Kuh, Diana
lyricists_name: Muthuri, Stella
lyricists_id: RCOOP16
lyricists_id: RHARD63
lyricists_id: DKUHX97
lyricists_id: SGMUT15
actors_name: Cuccu, Clara
actors_id: CCCUC40
actors_role: owner
full_text_status: public
publication: Scientific Reports
volume: 8
article_number: 16309
event_location: England
issn: 2045-2322
citation:        Muthuri, SG;    Pavlova, AV;    Saunders, FR;    Hardy, RJ;    Gregory, JS;    Barr, RJ;    Martin, KR;                 ... Cooper, R; + view all <#>        Muthuri, SG;  Pavlova, AV;  Saunders, FR;  Hardy, RJ;  Gregory, JS;  Barr, RJ;  Martin, KR;  Adams, JE;  Kuh, D;  Aspden, RM;  Cooper, R;   - view fewer <#>    (2018)    Associations between back pain across adulthood and spine shape in early old age in a British birth cohort.                   Scientific Reports , 8     , Article 16309.  10.1038/s41598-018-34628-9 <https://doi.org/10.1038/s41598-018-34628-9>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10061481/1/Muthuri_s41598-018-34628-9.pdf