eprintid: 10060731 rev_number: 36 eprint_status: archive userid: 608 dir: disk0/10/06/07/31 datestamp: 2018-11-07 16:35:08 lastmod: 2021-12-10 01:04:45 status_changed: 2018-11-07 16:35:08 type: article metadata_visibility: show creators_name: Skaaby, T creators_name: Kilpeläinen, TO creators_name: Taylor, AE creators_name: Mahendran, Y creators_name: Wong, A creators_name: Ahluwalia, TS creators_name: Paternoster, L creators_name: Trompet, S creators_name: Stott, DJ creators_name: Flexeder, C creators_name: Zhou, A creators_name: Brusselle, G creators_name: Sajjad, A creators_name: Lahousse, L creators_name: Tiemeier, H creators_name: Have, CT creators_name: Thuesen, BH creators_name: Kårhus, LL creators_name: Møllehave, LT creators_name: Leth-Møller, KB creators_name: Shabanzadeh, DM creators_name: Gonzalez-Quintela, A creators_name: Power, C creators_name: Hyppönen, E creators_name: Kuh, D creators_name: Hardy, R creators_name: Meitinger, T creators_name: Jukema, JW creators_name: Völker, U creators_name: Nauck, M creators_name: Völzke, H creators_name: Friedrich, N creators_name: Bonten, TN creators_name: Noordam, R creators_name: Mook-Kanamori, DO creators_name: Tolstrup, JS creators_name: Taube, C creators_name: Peters, A creators_name: Grallert, H creators_name: Strauch, K creators_name: Schulz, H creators_name: Grarup, N creators_name: Hansen, T creators_name: Pedersen, O creators_name: Burgess, S creators_name: Munafò, MR creators_name: Linneberg, A title: Association of alcohol consumption with allergic disease and asthma: a multi-centre Mendelian randomization analysis ispublished: pub divisions: UCL divisions: B16 divisions: B14 divisions: J81 divisions: B02 divisions: D14 divisions: GA3 divisions: G17 divisions: D13 divisions: G25 keywords: Alcohol, allergic disease, allergic sensitization, asthma, hay fever, mendelian randomization note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. abstract: AIMS: To use the rs1229984 variant associated with alcohol consumption as an instrument for alcohol consumption to test the causality of the association of alcohol consumption with hay fever, asthma, allergic sensitization and serum total immunoglobulin (Ig)E. DESIGN: Observational and Mendelian randomization analyses using genetic variants as unbiased markers of exposure to estimate causal effects, subject to certain assumptions. SETTING: Europe. PARTICIPANTS: We included a total of 466 434 people aged 15-82 years from 17 population-based studies conducted from 1997 to 2015. MEASUREMENTS: The rs1229984 (ADH1B) was genotyped; alcohol consumption, hay fever and asthma were self-reported. Specific and total IgE were measured from serum samples. FINDINGS: Observational analyses showed that ever-drinking versus non-drinking, but not amount of alcohol intake, was positively associated with hay fever and inversely associated with asthma but not with allergic sensitization or serum total immunoglobulin (Ig)E. However, Mendelian randomization analyses did not suggest that the observational associations are causal. The causal odds ratio (OR) per genetically assessed unit of alcohol/week was an OR = 0.907 [95% confidence interval (CI) = 0.806, 1.019; P = 0.101] for hay fever, an OR = 0.897 (95% CI = 0.790, 1.019; P = 0.095) for asthma, an OR = 0.971 (95% CI = 0.804, 1.174; P = 0.763) for allergic sensitization and a 4.7% change (95% CI = -5.5%, 14.9%; P = 0.366) for total IgE. CONCLUSIONS: In observational analyses, ever-drinking versus not drinking was positively associated with hay fever and negatively associated with asthma. However, the Mendelian randomization results were not consistent with these associations being causal. date: 2019-02 date_type: published official_url: https://doi.org/10.1111/add.14438 oa_status: green full_text_type: other language: eng primo: open primo_central: open_green verified: verified_manual elements_id: 1586315 doi: 10.1111/add.14438 lyricists_name: Hardy, Rebecca lyricists_name: Hypponen, Elina lyricists_name: Kuh, Diana lyricists_name: Power, Christine lyricists_name: Wong, Andrew lyricists_id: RHARD63 lyricists_id: EHYPP25 lyricists_id: DKUHX97 lyricists_id: CPOWE17 lyricists_id: AWKWO84 actors_name: Waragoda Vitharana, Nimal actors_id: NWARR44 actors_role: owner full_text_status: public publication: Addiction volume: 114 number: 2 pagerange: 216-225 event_location: England issn: 1360-0443 citation: Skaaby, T; Kilpeläinen, TO; Taylor, AE; Mahendran, Y; Wong, A; Ahluwalia, TS; Paternoster, L; ... Linneberg, A; + view all <#> Skaaby, T; Kilpeläinen, TO; Taylor, AE; Mahendran, Y; Wong, A; Ahluwalia, TS; Paternoster, L; Trompet, S; Stott, DJ; Flexeder, C; Zhou, A; Brusselle, G; Sajjad, A; Lahousse, L; Tiemeier, H; Have, CT; Thuesen, BH; Kårhus, LL; Møllehave, LT; Leth-Møller, KB; Shabanzadeh, DM; Gonzalez-Quintela, A; Power, C; Hyppönen, E; Kuh, D; Hardy, R; Meitinger, T; Jukema, JW; Völker, U; Nauck, M; Völzke, H; Friedrich, N; Bonten, TN; Noordam, R; Mook-Kanamori, DO; Tolstrup, JS; Taube, C; Peters, A; Grallert, H; Strauch, K; Schulz, H; Grarup, N; Hansen, T; Pedersen, O; Burgess, S; Munafò, MR; Linneberg, A; - view fewer <#> (2019) Association of alcohol consumption with allergic disease and asthma: a multi-centre Mendelian randomization analysis. Addiction , 114 (2) pp. 216-225. 10.1111/add.14438 <https://doi.org/10.1111/add.14438>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10060731/1/Hardy_Alcohol%20allergy%20manuscript.pdf