eprintid: 10060731
rev_number: 36
eprint_status: archive
userid: 608
dir: disk0/10/06/07/31
datestamp: 2018-11-07 16:35:08
lastmod: 2021-12-10 01:04:45
status_changed: 2018-11-07 16:35:08
type: article
metadata_visibility: show
creators_name: Skaaby, T
creators_name: Kilpeläinen, TO
creators_name: Taylor, AE
creators_name: Mahendran, Y
creators_name: Wong, A
creators_name: Ahluwalia, TS
creators_name: Paternoster, L
creators_name: Trompet, S
creators_name: Stott, DJ
creators_name: Flexeder, C
creators_name: Zhou, A
creators_name: Brusselle, G
creators_name: Sajjad, A
creators_name: Lahousse, L
creators_name: Tiemeier, H
creators_name: Have, CT
creators_name: Thuesen, BH
creators_name: Kårhus, LL
creators_name: Møllehave, LT
creators_name: Leth-Møller, KB
creators_name: Shabanzadeh, DM
creators_name: Gonzalez-Quintela, A
creators_name: Power, C
creators_name: Hyppönen, E
creators_name: Kuh, D
creators_name: Hardy, R
creators_name: Meitinger, T
creators_name: Jukema, JW
creators_name: Völker, U
creators_name: Nauck, M
creators_name: Völzke, H
creators_name: Friedrich, N
creators_name: Bonten, TN
creators_name: Noordam, R
creators_name: Mook-Kanamori, DO
creators_name: Tolstrup, JS
creators_name: Taube, C
creators_name: Peters, A
creators_name: Grallert, H
creators_name: Strauch, K
creators_name: Schulz, H
creators_name: Grarup, N
creators_name: Hansen, T
creators_name: Pedersen, O
creators_name: Burgess, S
creators_name: Munafò, MR
creators_name: Linneberg, A
title: Association of alcohol consumption with allergic disease and asthma: a multi-centre Mendelian randomization analysis
ispublished: pub
divisions: UCL
divisions: B16
divisions: B14
divisions: J81
divisions: B02
divisions: D14
divisions: GA3
divisions: G17
divisions: D13
divisions: G25
keywords: Alcohol, allergic disease, allergic sensitization, asthma, hay fever, mendelian randomization
note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
abstract: AIMS: To use the rs1229984 variant associated with alcohol consumption as an instrument for alcohol consumption to test the causality of the association of alcohol consumption with hay fever, asthma, allergic sensitization and serum total immunoglobulin (Ig)E. DESIGN: Observational and Mendelian randomization analyses using genetic variants as unbiased markers of exposure to estimate causal effects, subject to certain assumptions. SETTING: Europe. PARTICIPANTS: We included a total of 466 434 people aged 15-82 years from 17 population-based studies conducted from 1997 to 2015. MEASUREMENTS: The rs1229984 (ADH1B) was genotyped; alcohol consumption, hay fever and asthma were self-reported. Specific and total IgE were measured from serum samples. FINDINGS: Observational analyses showed that ever-drinking versus non-drinking, but not amount of alcohol intake, was positively associated with hay fever and inversely associated with asthma but not with allergic sensitization or serum total immunoglobulin (Ig)E. However, Mendelian randomization analyses did not suggest that the observational associations are causal. The causal odds ratio (OR) per genetically assessed unit of alcohol/week was an OR = 0.907 [95% confidence interval (CI) = 0.806, 1.019; P = 0.101] for hay fever, an OR = 0.897 (95% CI = 0.790, 1.019; P = 0.095) for asthma, an OR = 0.971 (95% CI =  0.804, 1.174; P = 0.763) for allergic sensitization and a 4.7% change (95% CI = -5.5%, 14.9%; P = 0.366) for total IgE. CONCLUSIONS: In observational analyses, ever-drinking versus not drinking was positively associated with hay fever and negatively associated with asthma. However, the Mendelian randomization results were not consistent with these associations being causal.
date: 2019-02
date_type: published
official_url: https://doi.org/10.1111/add.14438
oa_status: green
full_text_type: other
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1586315
doi: 10.1111/add.14438
lyricists_name: Hardy, Rebecca
lyricists_name: Hypponen, Elina
lyricists_name: Kuh, Diana
lyricists_name: Power, Christine
lyricists_name: Wong, Andrew
lyricists_id: RHARD63
lyricists_id: EHYPP25
lyricists_id: DKUHX97
lyricists_id: CPOWE17
lyricists_id: AWKWO84
actors_name: Waragoda Vitharana, Nimal
actors_id: NWARR44
actors_role: owner
full_text_status: public
publication: Addiction
volume: 114
number: 2
pagerange: 216-225
event_location: England
issn: 1360-0443
citation:        Skaaby, T;    Kilpeläinen, TO;    Taylor, AE;    Mahendran, Y;    Wong, A;    Ahluwalia, TS;    Paternoster, L;                                                                                                                                                                 ... Linneberg, A; + view all <#>        Skaaby, T;  Kilpeläinen, TO;  Taylor, AE;  Mahendran, Y;  Wong, A;  Ahluwalia, TS;  Paternoster, L;  Trompet, S;  Stott, DJ;  Flexeder, C;  Zhou, A;  Brusselle, G;  Sajjad, A;  Lahousse, L;  Tiemeier, H;  Have, CT;  Thuesen, BH;  Kårhus, LL;  Møllehave, LT;  Leth-Møller, KB;  Shabanzadeh, DM;  Gonzalez-Quintela, A;  Power, C;  Hyppönen, E;  Kuh, D;  Hardy, R;  Meitinger, T;  Jukema, JW;  Völker, U;  Nauck, M;  Völzke, H;  Friedrich, N;  Bonten, TN;  Noordam, R;  Mook-Kanamori, DO;  Tolstrup, JS;  Taube, C;  Peters, A;  Grallert, H;  Strauch, K;  Schulz, H;  Grarup, N;  Hansen, T;  Pedersen, O;  Burgess, S;  Munafò, MR;  Linneberg, A;   - view fewer <#>    (2019)    Association of alcohol consumption with allergic disease and asthma: a multi-centre Mendelian randomization analysis.                   Addiction , 114  (2)   pp. 216-225.    10.1111/add.14438 <https://doi.org/10.1111/add.14438>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10060731/1/Hardy_Alcohol%20allergy%20manuscript.pdf