<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> . <> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery.ucl.ac.uk/id/eprint/10060514> . <https://discovery.ucl.ac.uk/id/eprint/10060514> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/AcademicArticle> . <https://discovery.ucl.ac.uk/id/eprint/10060514> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Article> . <https://discovery.ucl.ac.uk/id/eprint/10060514> <http://purl.org/dc/terms/title> "Cerebrospinal fluid tau, A beta, and sTREM2 in Former National Football League Players: Modeling the relationship between repetitive head impacts, microglial activation, and neurodegeneration"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10060514> <http://purl.org/ontology/bibo/abstract> "Introduction:\r\nCerebrospinal fluid (CSF) protein analysis may facilitate detection and elucidate mechanisms of neurological consequences from repetitive head impacts (RHI), such as chronic traumatic encephalopathy. We examined CSF concentrations of total tau (t-tau), phosphorylated tau, and amyloid β1-42 and their association with RHI in former National Football League (NFL) players. The role of microglial activation (using sTREM2) was examined as a pathogenic mechanism of chronic traumatic encephalopathy. // \r\n\r\nMethods:\r\nSixty-eight former NFL players and 21 controls underwent lumbar puncture to quantify t-tau, p-tau181, amyloid β1-42, and sTREM2 in the CSF using immunoassays. The cumulative head impact index estimated RHI. // \r\n\r\nResults:\r\nNo between-group differences for CSF analytes emerged. In the former NFL players, the cumulative head impact index predicted higher t-tau concentrations (P = .041), and higher sTREM2 levels were associated with higher t-tau concentrations (P = .009). // \r\n\r\nDiscussion: \r\nIn this sample of former NFL players, greater RHI and increased microglial activation were associated with higher CSF t-tau concentrations."^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10060514> <http://purl.org/dc/terms/date> "2018-09" . <https://discovery.ucl.ac.uk/id/document/774800> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Document> . <https://discovery.ucl.ac.uk/id/eprint/10060514> <http://purl.org/ontology/bibo/volume> "14" . <https://discovery.ucl.ac.uk/id/eprint/10060514> <http://purl.org/ontology/bibo/issue> "9" . <https://discovery.ucl.ac.uk/id/org/ext-9ab12bce4ed1db8d63802ba79cf39587> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Organization> . <https://discovery.ucl.ac.uk/id/org/ext-9ab12bce4ed1db8d63802ba79cf39587> <http://xmlns.com/foaf/0.1/name> "ELSEVIER SCIENCE INC"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10060514> <http://purl.org/dc/terms/publisher> <https://discovery.ucl.ac.uk/id/org/ext-9ab12bce4ed1db8d63802ba79cf39587> . <https://discovery.ucl.ac.uk/id/publication/ext-15525279> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Collection> . <https://discovery.ucl.ac.uk/id/publication/ext-15525279> <http://xmlns.com/foaf/0.1/name> "Alzheimer's & Dementia"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10060514> <http://purl.org/dc/terms/isPartOf> <https://discovery.ucl.ac.uk/id/publication/ext-15525279> . <https://discovery.ucl.ac.uk/id/publication/ext-15525279> <http://www.w3.org/2002/07/owl#sameAs> <urn:issn:15525279> . <https://discovery.ucl.ac.uk/id/publication/ext-15525279> <http://purl.org/ontology/bibo/issn> "15525279" . <https://discovery.ucl.ac.uk/id/eprint/10060514> <http://purl.org/ontology/bibo/status> <http://purl.org/ontology/bibo/status/published> . <https://discovery.ucl.ac.uk/id/eprint/10060514> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-5c85c69fd907df84b8397c0a52cc6887> . <https://discovery.ucl.ac.uk/id/eprint/10060514> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10060514#authors> . <https://discovery.ucl.ac.uk/id/eprint/10060514#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_1> <https://discovery.ucl.ac.uk/id/person/ext-5c85c69fd907df84b8397c0a52cc6887> . <https://discovery.ucl.ac.uk/id/eprint/10060514> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-8b57b148edcf8dacfed27bb70d1d8403> . <https://discovery.ucl.ac.uk/id/eprint/10060514> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10060514#authors> . <https://discovery.ucl.ac.uk/id/eprint/10060514#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_2> <https://discovery.ucl.ac.uk/id/person/ext-8b57b148edcf8dacfed27bb70d1d8403> . <https://discovery.ucl.ac.uk/id/eprint/10060514> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-39f10bc47cbd50d5d950556d64a3813e> . <https://discovery.ucl.ac.uk/id/eprint/10060514> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10060514#authors> . <https://discovery.ucl.ac.uk/id/eprint/10060514#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_3> <https://discovery.ucl.ac.uk/id/person/ext-39f10bc47cbd50d5d950556d64a3813e> . <https://discovery.ucl.ac.uk/id/eprint/10060514> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-e96cdd2e16d71818e9a8cddd03b7f0a2> . <https://discovery.ucl.ac.uk/id/eprint/10060514> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10060514#authors> . <https://discovery.ucl.ac.uk/id/eprint/10060514#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_4> <https://discovery.ucl.ac.uk/id/person/ext-e96cdd2e16d71818e9a8cddd03b7f0a2> . <https://discovery.ucl.ac.uk/id/eprint/10060514> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-8e3829a9a764d8576143b97db9bf2e86> . <https://discovery.ucl.ac.uk/id/eprint/10060514> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10060514#authors> . <https://discovery.ucl.ac.uk/id/eprint/10060514#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_5> <https://discovery.ucl.ac.uk/id/person/ext-8e3829a9a764d8576143b97db9bf2e86> . <https://discovery.ucl.ac.uk/id/eprint/10060514> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-ec0606ca099b4c2f9a7096b51cc44876> . <https://discovery.ucl.ac.uk/id/eprint/10060514> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10060514#authors> . <https://discovery.ucl.ac.uk/id/eprint/10060514#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_6> <https://discovery.ucl.ac.uk/id/person/ext-ec0606ca099b4c2f9a7096b51cc44876> . <https://discovery.ucl.ac.uk/id/eprint/10060514> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-76b53a58dab1c2346088fa98febb141c> . <https://discovery.ucl.ac.uk/id/eprint/10060514> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10060514#authors> . <https://discovery.ucl.ac.uk/id/eprint/10060514#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_7> <https://discovery.ucl.ac.uk/id/person/ext-76b53a58dab1c2346088fa98febb141c> . <https://discovery.ucl.ac.uk/id/eprint/10060514> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-dd26c4ea1702627efb9d2a3db8e06fa7> . <https://discovery.ucl.ac.uk/id/eprint/10060514> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10060514#authors> . <https://discovery.ucl.ac.uk/id/eprint/10060514#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_8> <https://discovery.ucl.ac.uk/id/person/ext-dd26c4ea1702627efb9d2a3db8e06fa7> . <https://discovery.ucl.ac.uk/id/eprint/10060514> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-bc9602116cad72c601c492cdbc377ed1> . <https://discovery.ucl.ac.uk/id/eprint/10060514> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10060514#authors> . <https://discovery.ucl.ac.uk/id/eprint/10060514#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_9> <https://discovery.ucl.ac.uk/id/person/ext-bc9602116cad72c601c492cdbc377ed1> . <https://discovery.ucl.ac.uk/id/eprint/10060514> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-05a989ddf903cc6c71ce6b554cc3dea0> . <https://discovery.ucl.ac.uk/id/eprint/10060514> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10060514#authors> . <https://discovery.ucl.ac.uk/id/eprint/10060514#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_10> <https://discovery.ucl.ac.uk/id/person/ext-05a989ddf903cc6c71ce6b554cc3dea0> . <https://discovery.ucl.ac.uk/id/eprint/10060514> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-cf265a5fd9f9ad91655706d72433f289> . <https://discovery.ucl.ac.uk/id/eprint/10060514> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10060514#authors> . <https://discovery.ucl.ac.uk/id/eprint/10060514#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_11> <https://discovery.ucl.ac.uk/id/person/ext-cf265a5fd9f9ad91655706d72433f289> . <https://discovery.ucl.ac.uk/id/eprint/10060514> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-ad047e8d1bc709bd6b924c1f170be3cb> . <https://discovery.ucl.ac.uk/id/eprint/10060514> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10060514#authors> . <https://discovery.ucl.ac.uk/id/eprint/10060514#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_12> <https://discovery.ucl.ac.uk/id/person/ext-ad047e8d1bc709bd6b924c1f170be3cb> . <https://discovery.ucl.ac.uk/id/eprint/10060514> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-9259c17aa2c32d1dcedc0fb206ed7be7> . <https://discovery.ucl.ac.uk/id/eprint/10060514> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10060514#authors> . <https://discovery.ucl.ac.uk/id/eprint/10060514#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_13> <https://discovery.ucl.ac.uk/id/person/ext-9259c17aa2c32d1dcedc0fb206ed7be7> . <https://discovery.ucl.ac.uk/id/eprint/10060514> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-22f2c0fb39bf8cbc4a0d5f439fb0b95a> . <https://discovery.ucl.ac.uk/id/eprint/10060514> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10060514#authors> . <https://discovery.ucl.ac.uk/id/eprint/10060514#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_14> <https://discovery.ucl.ac.uk/id/person/ext-22f2c0fb39bf8cbc4a0d5f439fb0b95a> . <https://discovery.ucl.ac.uk/id/eprint/10060514> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-b26f4aeac75ab95fc591894609b68150> . <https://discovery.ucl.ac.uk/id/eprint/10060514> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10060514#authors> . <https://discovery.ucl.ac.uk/id/eprint/10060514#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_15> <https://discovery.ucl.ac.uk/id/person/ext-b26f4aeac75ab95fc591894609b68150> . <https://discovery.ucl.ac.uk/id/eprint/10060514> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-23fba6d7f42f1b0a80680528a665dcda> . <https://discovery.ucl.ac.uk/id/eprint/10060514> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10060514#authors> . <https://discovery.ucl.ac.uk/id/eprint/10060514#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_16> <https://discovery.ucl.ac.uk/id/person/ext-23fba6d7f42f1b0a80680528a665dcda> . <https://discovery.ucl.ac.uk/id/eprint/10060514> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-5ff41ccd6d0f2f1f217aec348632abee> . <https://discovery.ucl.ac.uk/id/eprint/10060514> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10060514#authors> . <https://discovery.ucl.ac.uk/id/eprint/10060514#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_17> <https://discovery.ucl.ac.uk/id/person/ext-5ff41ccd6d0f2f1f217aec348632abee> . <https://discovery.ucl.ac.uk/id/eprint/10060514> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-a7e912b9e4a90d7ca167613478868237> . <https://discovery.ucl.ac.uk/id/eprint/10060514> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10060514#authors> . <https://discovery.ucl.ac.uk/id/eprint/10060514#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_18> <https://discovery.ucl.ac.uk/id/person/ext-a7e912b9e4a90d7ca167613478868237> . <https://discovery.ucl.ac.uk/id/person/ext-e96cdd2e16d71818e9a8cddd03b7f0a2> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-e96cdd2e16d71818e9a8cddd03b7f0a2> <http://xmlns.com/foaf/0.1/givenName> "A"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-e96cdd2e16d71818e9a8cddd03b7f0a2> <http://xmlns.com/foaf/0.1/familyName> "Heslegrave"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-e96cdd2e16d71818e9a8cddd03b7f0a2> <http://xmlns.com/foaf/0.1/name> "A Heslegrave"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-5c85c69fd907df84b8397c0a52cc6887> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-5c85c69fd907df84b8397c0a52cc6887> <http://xmlns.com/foaf/0.1/givenName> "ML"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-5c85c69fd907df84b8397c0a52cc6887> <http://xmlns.com/foaf/0.1/familyName> "Alosco"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-5c85c69fd907df84b8397c0a52cc6887> <http://xmlns.com/foaf/0.1/name> "ML Alosco"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-ad047e8d1bc709bd6b924c1f170be3cb> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-ad047e8d1bc709bd6b924c1f170be3cb> <http://xmlns.com/foaf/0.1/givenName> "RC"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-ad047e8d1bc709bd6b924c1f170be3cb> <http://xmlns.com/foaf/0.1/familyName> "Cantu"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-ad047e8d1bc709bd6b924c1f170be3cb> <http://xmlns.com/foaf/0.1/name> "RC Cantu"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-b26f4aeac75ab95fc591894609b68150> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-b26f4aeac75ab95fc591894609b68150> <http://xmlns.com/foaf/0.1/givenName> "JQ"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-b26f4aeac75ab95fc591894609b68150> <http://xmlns.com/foaf/0.1/familyName> "Trojanowski"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-b26f4aeac75ab95fc591894609b68150> <http://xmlns.com/foaf/0.1/name> "JQ Trojanowski"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-8e3829a9a764d8576143b97db9bf2e86> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-8e3829a9a764d8576143b97db9bf2e86> <http://xmlns.com/foaf/0.1/givenName> "CM"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-8e3829a9a764d8576143b97db9bf2e86> <http://xmlns.com/foaf/0.1/familyName> "Baugh"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-8e3829a9a764d8576143b97db9bf2e86> <http://xmlns.com/foaf/0.1/name> "CM Baugh"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-9259c17aa2c32d1dcedc0fb206ed7be7> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-9259c17aa2c32d1dcedc0fb206ed7be7> <http://xmlns.com/foaf/0.1/givenName> "AC"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-9259c17aa2c32d1dcedc0fb206ed7be7> <http://xmlns.com/foaf/0.1/familyName> "Mckee"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-9259c17aa2c32d1dcedc0fb206ed7be7> <http://xmlns.com/foaf/0.1/name> "AC Mckee"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-05a989ddf903cc6c71ce6b554cc3dea0> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-05a989ddf903cc6c71ce6b554cc3dea0> <http://xmlns.com/foaf/0.1/givenName> "J"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-05a989ddf903cc6c71ce6b554cc3dea0> <http://xmlns.com/foaf/0.1/familyName> "Mez"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-05a989ddf903cc6c71ce6b554cc3dea0> <http://xmlns.com/foaf/0.1/name> "J Mez"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-dd26c4ea1702627efb9d2a3db8e06fa7> 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