eprintid: 10060224
rev_number: 16
eprint_status: archive
userid: 608
dir: disk0/10/06/02/24
datestamp: 2018-10-31 13:15:26
lastmod: 2021-09-17 22:08:22
status_changed: 2018-10-31 13:15:26
type: article
metadata_visibility: show
creators_name: Oh, ES
creators_name: Blennow, K
creators_name: Bigelow, GE
creators_name: Inouye, SK
creators_name: Marcantonio, ER
creators_name: Neufeld, KJ
creators_name: Rosenberg, PB
creators_name: Troncoso, JC
creators_name: Wang, N-Y
creators_name: Zetterberg, H
creators_name: Sieber, FE
creators_name: Lyketsos, CG
title: Abnormal Csf Amyloid-beta 42 and Tau Levels in Hip Fracture Patients Without Dementia
ispublished: pub
divisions: UCL
divisions: B02
divisions: C07
divisions: D07
divisions: F86
note: This is an open access
article distributed under the terms of the Creative
Commons Attribution License, which permits
unrestricted use, distribution, and reproduction in
any medium, provided the original author and
source are credited.
abstract: BACKGROUND:
There is strong association of Alzheimer’s disease (AD) pathology with gait disorder and falls in older adults without dementia. The goal of the study was to examine the prevalence and severity of AD pathology in older adults without dementia who fall and sustain hip fracture.

METHODS:
Cerebrospinal fluid (CSF) was obtained from 168 hip fracture patients. CSF Aβ42/40 ratio, p-tau, and t-tau measures were dichotomized into normal vs. abnormal, and categorized according to the A/T/N classification.

RESULTS:
Among the hip fracture patients, 88.6% of the cognitively normal (Clinical Dementia Rating-CDR 0; n = 70) and 98.8% with mild cognitive impairment (CDR 0.5; n = 81) fell in the abnormal biomarker categories by the A/T/N classification.

CONCLUSIONS:
A large proportion of older hip fracture patients have CSF evidence of AD pathology. Preoperative determination of AD biomarkers may play a crucial role in identifying persons without dementia who have underlying AD pathology in perioperative settings.
date: 2018-09-25
date_type: published
publisher: PUBLIC LIBRARY SCIENCE
official_url: https://doi.org/10.1371/journal.pone.0204695
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1589490
doi: 10.1371/journal.pone.0204695
lyricists_name: Zetterberg, Henrik
lyricists_id: HZETT94
actors_name: Bracey, Alan
actors_id: ABBRA90
actors_role: owner
full_text_status: public
publication: PLoS One
volume: 13
number: 9
article_number: e0204695
pages: 10
issn: 1932-6203
citation:        Oh, ES;    Blennow, K;    Bigelow, GE;    Inouye, SK;    Marcantonio, ER;    Neufeld, KJ;    Rosenberg, PB;                     ... Lyketsos, CG; + view all <#>        Oh, ES;  Blennow, K;  Bigelow, GE;  Inouye, SK;  Marcantonio, ER;  Neufeld, KJ;  Rosenberg, PB;  Troncoso, JC;  Wang, N-Y;  Zetterberg, H;  Sieber, FE;  Lyketsos, CG;   - view fewer <#>    (2018)    Abnormal Csf Amyloid-beta 42 and Tau Levels in Hip Fracture Patients Without Dementia.                   PLoS One , 13  (9)    , Article e0204695.  10.1371/journal.pone.0204695 <https://doi.org/10.1371/journal.pone.0204695>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10060224/1/journal.pone.0204695.pdf