eprintid: 10060042 rev_number: 28 eprint_status: archive userid: 608 dir: disk0/10/06/00/42 datestamp: 2018-10-30 16:41:18 lastmod: 2021-12-05 00:48:57 status_changed: 2019-01-31 12:26:17 type: article metadata_visibility: show creators_name: Park, C creators_name: Fraser, A creators_name: Howe, LD creators_name: Jones, S creators_name: Smith, GD creators_name: Lawlor, DA creators_name: Chaturvedi, N creators_name: Hughes, AD title: Elevated Blood Pressure in Adolescence Is Attributable to a Combination of Elevated Cardiac Output and Total Peripheral Resistance: Evidence Against a Hyperkinetic State ispublished: pub divisions: UCL divisions: B02 divisions: D14 divisions: GA3 divisions: G17 keywords: blood pressure, vascular resistance, cardiac output, stroke volume, heart rate note: This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. abstract: Unlike in older people, it has been suggested that elevated blood pressure (BP) in young people is because of high cardiac output accompanied by normal total peripheral resistance (TPR)—a hyperkinetic/hyperdynamic circulation. We investigated this in a large, United Kingdom-based birth cohort of adolescents. The study was conducted on 2091 17-year-old participants in the ALSPAC (Avon Longitudinal Study of Parents and Children)—a prospective population-based birth cohort study. BP measurement and echocardiography were performed, and heart rate (HR), stroke volume (SV), and TPR were calculated. Data are means (SD). Higher quintiles of systolic BP were associated with higher SV, higher HR, and higher TPR. The proportional contribution made by SV, HR, and TPR to mean arterial pressure differed little by systolic BP quintile (SV [32%–34%], HR [25%–29%], and TPR [39%–41%]). Higher BP is attributable to a combination of higher cardiac output (ie, SV×HR) and higher TPR in a population-based sample of adolescents. There is no evidence of a disproportionate contribution from elevated cardiac output at higher BP levels. date: 2018-11 date_type: published publisher: LIPPINCOTT WILLIAMS & WILKINS official_url: https://doi.org/10.1161/HYPERTENSIONAHA.118.11925 oa_status: green full_text_type: pub language: eng primo: open primo_central: open_green verified: verified_manual elements_id: 1597442 doi: 10.1161/HYPERTENSIONAHA.118.11925 lyricists_name: Chaturvedi, Nishi lyricists_name: Hughes, Alun lyricists_name: Jones, Siana lyricists_name: Park, Chloe lyricists_id: NCHAT95 lyricists_id: ADHUG42 lyricists_id: SJONE06 lyricists_id: CMPAR82 actors_name: Hughes, Alun actors_id: ADHUG42 actors_role: owner full_text_status: public publication: Hypertension volume: 72 number: 5 pagerange: 1103-1108 pages: 6 issn: 1524-4563 citation: Park, C; Fraser, A; Howe, LD; Jones, S; Smith, GD; Lawlor, DA; Chaturvedi, N; Park, C; Fraser, A; Howe, LD; Jones, S; Smith, GD; Lawlor, DA; Chaturvedi, N; Hughes, AD; - view fewer <#> (2018) Elevated Blood Pressure in Adolescence Is Attributable to a Combination of Elevated Cardiac Output and Total Peripheral Resistance: Evidence Against a Hyperkinetic State. Hypertension , 72 (5) pp. 1103-1108. 10.1161/HYPERTENSIONAHA.118.11925 <https://doi.org/10.1161/HYPERTENSIONAHA.118.11925>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10060042/1/HYPERTENSIONAHA.118.11925.pdf