eprintid: 10060042
rev_number: 28
eprint_status: archive
userid: 608
dir: disk0/10/06/00/42
datestamp: 2018-10-30 16:41:18
lastmod: 2021-12-05 00:48:57
status_changed: 2019-01-31 12:26:17
type: article
metadata_visibility: show
creators_name: Park, C
creators_name: Fraser, A
creators_name: Howe, LD
creators_name: Jones, S
creators_name: Smith, GD
creators_name: Lawlor, DA
creators_name: Chaturvedi, N
creators_name: Hughes, AD
title: Elevated Blood Pressure in Adolescence Is Attributable to a Combination of Elevated Cardiac Output and Total Peripheral Resistance: Evidence Against a Hyperkinetic State
ispublished: pub
divisions: UCL
divisions: B02
divisions: D14
divisions: GA3
divisions: G17
keywords: blood pressure, vascular resistance, cardiac output, stroke volume, heart rate
note: This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
abstract: Unlike in older people, it has been suggested that elevated blood pressure (BP) in young people is because of high cardiac output accompanied by normal total peripheral resistance (TPR)—a hyperkinetic/hyperdynamic circulation. We investigated this in a large, United Kingdom-based birth cohort of adolescents. The study was conducted on 2091 17-year-old participants in the ALSPAC (Avon Longitudinal Study of Parents and Children)—a prospective population-based birth cohort study. BP measurement and echocardiography were performed, and heart rate (HR), stroke volume (SV), and TPR were calculated. Data are means (SD). Higher quintiles of systolic BP were associated with higher SV, higher HR, and higher TPR. The proportional contribution made by SV, HR, and TPR to mean arterial pressure differed little by systolic BP quintile (SV [32%–34%], HR [25%–29%], and TPR [39%–41%]). Higher BP is attributable to a combination of higher cardiac output (ie, SV×HR) and higher TPR in a population-based sample of adolescents. There is no evidence of a disproportionate contribution from elevated cardiac output at higher BP levels.
date: 2018-11
date_type: published
publisher: LIPPINCOTT WILLIAMS & WILKINS
official_url: https://doi.org/10.1161/HYPERTENSIONAHA.118.11925
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1597442
doi: 10.1161/HYPERTENSIONAHA.118.11925
lyricists_name: Chaturvedi, Nishi
lyricists_name: Hughes, Alun
lyricists_name: Jones, Siana
lyricists_name: Park, Chloe
lyricists_id: NCHAT95
lyricists_id: ADHUG42
lyricists_id: SJONE06
lyricists_id: CMPAR82
actors_name: Hughes, Alun
actors_id: ADHUG42
actors_role: owner
full_text_status: public
publication: Hypertension
volume: 72
number: 5
pagerange: 1103-1108
pages: 6
issn: 1524-4563
citation:        Park, C;    Fraser, A;    Howe, LD;    Jones, S;    Smith, GD;    Lawlor, DA;    Chaturvedi, N;           Park, C;  Fraser, A;  Howe, LD;  Jones, S;  Smith, GD;  Lawlor, DA;  Chaturvedi, N;  Hughes, AD;   - view fewer <#>    (2018)    Elevated Blood Pressure in Adolescence Is Attributable to a Combination of Elevated Cardiac Output and Total Peripheral Resistance: Evidence Against a Hyperkinetic State.                   Hypertension , 72  (5)   pp. 1103-1108.    10.1161/HYPERTENSIONAHA.118.11925 <https://doi.org/10.1161/HYPERTENSIONAHA.118.11925>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10060042/1/HYPERTENSIONAHA.118.11925.pdf