TY  - JOUR
AV  - public
SN  - 1524-4563
N2  - Unlike in older people, it has been suggested that elevated blood pressure (BP) in young people is because of high cardiac output accompanied by normal total peripheral resistance (TPR)?a hyperkinetic/hyperdynamic circulation. We investigated this in a large, United Kingdom-based birth cohort of adolescents. The study was conducted on 2091 17-year-old participants in the ALSPAC (Avon Longitudinal Study of Parents and Children)?a prospective population-based birth cohort study. BP measurement and echocardiography were performed, and heart rate (HR), stroke volume (SV), and TPR were calculated. Data are means (SD). Higher quintiles of systolic BP were associated with higher SV, higher HR, and higher TPR. The proportional contribution made by SV, HR, and TPR to mean arterial pressure differed little by systolic BP quintile (SV [32%?34%], HR [25%?29%], and TPR [39%?41%]). Higher BP is attributable to a combination of higher cardiac output (ie, SV×HR) and higher TPR in a population-based sample of adolescents. There is no evidence of a disproportionate contribution from elevated cardiac output at higher BP levels.
SP  - 1103
JF  - Hypertension
PB  - LIPPINCOTT WILLIAMS & WILKINS
ID  - discovery10060042
UR  - https://doi.org/10.1161/HYPERTENSIONAHA.118.11925
N1  - This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
IS  - 5
A1  - Park, C
A1  - Fraser, A
A1  - Howe, LD
A1  - Jones, S
A1  - Smith, GD
A1  - Lawlor, DA
A1  - Chaturvedi, N
A1  - Hughes, AD
KW  - blood pressure
KW  -  vascular resistance
KW  -  cardiac output
KW  -  stroke volume
KW  -  heart rate
EP  - 1108
VL  - 72
Y1  - 2018/11//
TI  - Elevated Blood Pressure in Adolescence Is Attributable to a Combination of Elevated Cardiac Output and Total Peripheral Resistance: Evidence Against a Hyperkinetic State
ER  -