TY - JOUR AV - public SN - 1524-4563 N2 - Unlike in older people, it has been suggested that elevated blood pressure (BP) in young people is because of high cardiac output accompanied by normal total peripheral resistance (TPR)?a hyperkinetic/hyperdynamic circulation. We investigated this in a large, United Kingdom-based birth cohort of adolescents. The study was conducted on 2091 17-year-old participants in the ALSPAC (Avon Longitudinal Study of Parents and Children)?a prospective population-based birth cohort study. BP measurement and echocardiography were performed, and heart rate (HR), stroke volume (SV), and TPR were calculated. Data are means (SD). Higher quintiles of systolic BP were associated with higher SV, higher HR, and higher TPR. The proportional contribution made by SV, HR, and TPR to mean arterial pressure differed little by systolic BP quintile (SV [32%?34%], HR [25%?29%], and TPR [39%?41%]). Higher BP is attributable to a combination of higher cardiac output (ie, SV×HR) and higher TPR in a population-based sample of adolescents. There is no evidence of a disproportionate contribution from elevated cardiac output at higher BP levels. SP - 1103 JF - Hypertension PB - LIPPINCOTT WILLIAMS & WILKINS ID - discovery10060042 UR - https://doi.org/10.1161/HYPERTENSIONAHA.118.11925 N1 - This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. IS - 5 A1 - Park, C A1 - Fraser, A A1 - Howe, LD A1 - Jones, S A1 - Smith, GD A1 - Lawlor, DA A1 - Chaturvedi, N A1 - Hughes, AD KW - blood pressure KW - vascular resistance KW - cardiac output KW - stroke volume KW - heart rate EP - 1108 VL - 72 Y1 - 2018/11// TI - Elevated Blood Pressure in Adolescence Is Attributable to a Combination of Elevated Cardiac Output and Total Peripheral Resistance: Evidence Against a Hyperkinetic State ER -