eprintid: 10059856 rev_number: 27 eprint_status: archive userid: 608 dir: disk0/10/05/98/56 datestamp: 2018-11-02 14:09:44 lastmod: 2021-10-23 22:48:51 status_changed: 2018-11-02 14:12:11 type: article metadata_visibility: show creators_name: Nilholm, C creators_name: Roth, B creators_name: Höglund, P creators_name: Blennow, K creators_name: Englund, E creators_name: Hansson, O creators_name: Zetterberg, H creators_name: Ohlsson, B title: Dietary intervention with an Okinawan-based Nordic diet in type 2 diabetes renders decreased interleukin-18 concentrations and increased neurofilament light concentrations in plasma ispublished: pub divisions: UCL divisions: B02 divisions: C07 divisions: D07 divisions: F86 keywords: Cytokines, Glucose metabolism, IL-18, Inflammation, Neurofilament light, Okinawan-based Nordic diet, Type 2 diabetes note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. abstract: Food may induce inflammation and favor development of metabolic diseases, which have been associated with increased inflammation and potential risk of cognitive impairment. It is customary to know whether food or disease promote inflammation. Our hypothesis was that Okinawan-based Nordic (O-BN) diet leads to decreased circulating concentrations of inflammatory and neural biomarkers. The objectives of this study were to examine the effects of the O-BN diet on inflammatory and neural responses. First, 2 different breakfasts; one standard and another O-BN-based, were given in random order to 19 healthy volunteers. Second, a 12-week O-BN-dietary intervention was performed in type 2 diabetes mellitus (T2DM), where the participants were followed for another 16-weeks, with registration of anthropometry and metabolic parameters. Non-diabetic subjects served as controls at baseline. Plasma was analyzed for cytokines by a 10-plex Luminex assay and neurofilament light (NfL) by an ultrasensitive Single molecule assay. Cytokine levels decreased after a single breakfast intake, independent of diet composition. Cytokine levels were higher in T2DM than in controls. Anthropometric and metabolic parameters were improved by the dietary intervention. In parallel, cytokine levels were lowered, although only significantly for IL-18 (P =.001), with a tendency of significance for IL-12p70 (P =.07). Levels of IL-18 correlated with glucose, HbA1c and lipids, but not with body mass index, insulin or blood pressure. NfL levels increased during the intervention (P =.049). O-BN-based diet does not affect postprandial cytokine levels in health, whereas it renders decreased circulating IL-18 levels along with metabolic biomarkers in T2DM, with no beneficial effect on NfL. date: 2018-12 date_type: published official_url: https://doi.org/10.1016/j.nutres.2018.08.002 oa_status: green full_text_type: other language: eng primo: open primo_central: open_green article_type_text: Journal Article verified: verified_manual elements_id: 1594118 doi: 10.1016/j.nutres.2018.08.002 lyricists_name: Zetterberg, Henrik lyricists_id: HZETT94 actors_name: Zetterberg, Henrik actors_name: Harriot, Anne-Marie actors_id: HZETT94 actors_id: AHARA72 actors_role: owner actors_role: impersonator full_text_status: public publication: Nutrition Research volume: 60 pagerange: 13-25 issn: 1879-0739 citation: Nilholm, C; Roth, B; Höglund, P; Blennow, K; Englund, E; Hansson, O; Zetterberg, H; Nilholm, C; Roth, B; Höglund, P; Blennow, K; Englund, E; Hansson, O; Zetterberg, H; Ohlsson, B; - view fewer <#> (2018) Dietary intervention with an Okinawan-based Nordic diet in type 2 diabetes renders decreased interleukin-18 concentrations and increased neurofilament light concentrations in plasma. Nutrition Research , 60 pp. 13-25. 10.1016/j.nutres.2018.08.002 <https://doi.org/10.1016/j.nutres.2018.08.002>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10059856/1/Nilholm_Dietary%20intervention%20with%20an%20Okinawan-based%20Nordic%20diet.pdf