TY  - JOUR
N1  - This version is the author accepted manuscript. For information on re-use, please refer to the publisher?s terms and conditions.
IS  - 1-2
SP  - 90
VL  - 46
JF  - Dementia and Geriatric Cognitive Disorders
A1  - Johansson, L
A1  - Kern, S
A1  - Zetterberg, H
A1  - Blennow, K
A1  - Borjesson-Hansson, A
A1  - Rosengren, L
A1  - Guo, X
A1  - Skoog, I
SN  - 1421-9824
UR  - http://dx.doi.org/10.1159/000490885
TI  - Midlife Stress in Relation to Late-Life Cerebrospinal Fluid Biomarkers of Alzheimer's Disease: A 25-Year Follow-Up Study
EP  - 99
AV  - public
Y1  - 2018/09//
KW  - Science & Technology
KW  -  Life Sciences & Biomedicine
KW  -  Geriatrics & Gerontology
KW  -  Clinical Neurology
KW  -  Psychiatry
KW  -  Neurosciences & Neurology
KW  -  Amyloid
KW  -  Dementia
KW  -  Neuropathology
KW  -  Stress
KW  -  Tau protein
KW  -  Population study
KW  -  CHRONIC DISTRESS
KW  -  AMYLOID-BETA
KW  -  DEMENTIA
KW  -  CSF
KW  -  RISK
KW  -  TAU
KW  -  PERSONALITY
KW  -  POPULATION
KW  -  PROTEIN
KW  -  BRAIN
ID  - discovery10059850
N2  - Background/Aims: Psychological stress has previously been associated with higher risk of developing late-life dementia, especially Alzheimer?s disease (AD). This study tested whether longstanding midlife stress is related to cerebrospinal fluid (CSF) biomarkers of late-life AD, such as tau protein and amyloid beta (A?). Methods: The study included 79 nondemented females from the Prospective Population Study of Women in Gothenburg, Sweden, who responded to a standardized stress question at baseline (mean age 49 years) and underwent a lumbar puncture at follow-up 25 years later. Multiple linear regression models analyzed the relationships between midlife psychological stress and late-life CSF measures of total tau (t-tau), phosphorylated tau (p-tau), A?40, and A?42. Results: Longstanding stress in midlife was associated with higher levels of CSF t-tau (? = 0.64, p = 0.01) and A?40 (? = 0.60, p = 0.02) in late life. No associations were found between midlife stress and levels of p-tau or A?42. Conclusion: The findings suggest that longstanding stress stimulates unspecific neurodegenerative processes, but not the core processes of AD, at least not in the early phase of the disease. The association with higher concentration of CSF t-tau may reflect neural degeneration and the association with higher A?40 may be an early sign of A? overproduction or cerebrovascular processes in the brain.
PB  - KARGER
ER  -