eprintid: 10059578 rev_number: 20 eprint_status: archive userid: 608 dir: disk0/10/05/95/78 datestamp: 2018-11-21 12:52:25 lastmod: 2021-09-27 22:40:28 status_changed: 2018-11-21 12:52:25 type: article metadata_visibility: show creators_name: Malanchini, M creators_name: Smith-Woolley, E creators_name: Ayorech, Z creators_name: Rimfeld, K creators_name: Krapohl, E creators_name: Vuoksimaa, E creators_name: Korhonen, T creators_name: Bartels, M creators_name: van Beijsterveldt, TCEM creators_name: Rose, RJ creators_name: Lundström, S creators_name: Anckarsäter, H creators_name: Kaprio, J creators_name: Lichtenstein, P creators_name: Boomsma, DI creators_name: Plomin, R title: Aggressive behaviour in childhood and adolescence: the role of smoking during pregnancy, evidence from four twin cohorts in the EU-ACTION consortium ispublished: pub divisions: UCL divisions: B16 divisions: B14 note: This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited. abstract: BACKGROUND: Maternal smoking during pregnancy (MSDP) has been linked to offspring's externalizing problems. It has been argued that socio-demographic factors (e.g. maternal age and education), co-occurring environmental risk factors, or pleiotropic genetic effects may account for the association between MSDP and later outcomes. This study provides a comprehensive investigation of the association between MSDP and a single harmonized component of externalizing: aggressive behaviour, measured throughout childhood and adolescence. METHODS: Data came from four prospective twin cohorts – Twins Early Development Study, Netherlands Twin Register, Childhood and Adolescent Twin Study of Sweden, and FinnTwin12 study – who collaborate in the EU-ACTION consortium. Data from 30 708 unrelated individuals were analysed. Based on item level data, a harmonized measure of aggression was created at ages 9–10; 12; 14–15 and 16–18. RESULTS: MSDP predicted aggression in childhood and adolescence. A meta-analysis across the four samples found the independent effect of MSDP to be 0.4% (r = 0.066), this remained consistent when analyses were performed separately by sex. All other perinatal factors combined explained 1.1% of the variance in aggression across all ages and samples (r = 0.112). Paternal smoking and aggressive parenting strategies did not account for the MSDP-aggression association, consistent with the hypothesis of a small direct link between MSDP and aggression. CONCLUSION: Perinatal factors, including MSDP, account for a small portion of the variance in aggression in childhood and adolescence. Later experiences may play a greater role in shaping adolescents’ aggressive behaviour. date: 2018 official_url: https://doi.org/10.1017/S0033291718001344 oa_status: green full_text_type: pub language: eng primo: open primo_central: open_green article_type_text: Article verified: verified_manual elements_id: 1595642 doi: 10.1017/S0033291718001344 lyricists_name: Smith-Woolley, Emily lyricists_id: ESMIA08 actors_name: Cuccu, Clara actors_id: CCCUC40 actors_role: owner full_text_status: public publication: Psychological Medicine issn: 1469-8978 citation: Malanchini, M; Smith-Woolley, E; Ayorech, Z; Rimfeld, K; Krapohl, E; Vuoksimaa, E; Korhonen, T; ... Plomin, R; + view all <#> Malanchini, M; Smith-Woolley, E; Ayorech, Z; Rimfeld, K; Krapohl, E; Vuoksimaa, E; Korhonen, T; Bartels, M; van Beijsterveldt, TCEM; Rose, RJ; Lundström, S; Anckarsäter, H; Kaprio, J; Lichtenstein, P; Boomsma, DI; Plomin, R; - view fewer <#> (2018) Aggressive behaviour in childhood and adolescence: the role of smoking during pregnancy, evidence from four twin cohorts in the EU-ACTION consortium. Psychological Medicine 10.1017/S0033291718001344 <https://doi.org/10.1017/S0033291718001344>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10059578/1/Malanchini_Aggressive%20behaviour.pdf