eprintid: 10059493
rev_number: 23
eprint_status: archive
userid: 608
dir: disk0/10/05/94/93
datestamp: 2018-11-06 19:54:47
lastmod: 2021-10-23 01:43:08
status_changed: 2018-11-06 19:54:47
type: article
metadata_visibility: show
creators_name: Kouwenberg, CV
creators_name: Voermans, NC
creators_name: Quinlivan, R
creators_name: van den Engel-Hoek, L
title: Mastication and Oral Motor Function in McArdle Disease: Patient Reported Complaints
ispublished: pub
divisions: UCL
divisions: B02
divisions: C07
divisions: D07
divisions: F85
keywords: McArdle disease, glycogen storage disease type V, mastication, oral motor function
note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
abstract: Background: Exertional myalgia and cramps of the limb and trunk muscles are typical in McArdle disease, but mastication
and oral motor limitations have not been systematically investigated before.
Objective: Determine the reported prevalence and characteristics of limitations on oral motor activities, mastication, swallowing,
and other oral motor activities in patients with McArdle disease.
Methods: An observational study was carried out in 28 patients using a standardised questionnaire on mastication and oral
motor function.
Results: 57% of the participants reported difficulties with mastication. Muscle cramps during mastication occurred in 57%
of the patients. A feeling that food remains in the throat occurred in 32%. Adaptations during mastication were needed in
42% of the patients. Mastication difficulties, muscle cramps during mastication and mastication adjustments were inversely
correlated with age (r2 = –0.445, p < 0.05; r2 = –0.509, p < 0.01; r2 = –0.456, p < 0.05). Feeling of food remaining in throat,
cramps during mastication and during other oral motor muscle activities, were correlated with disease severity (r2 = 0.476,
p < 0.01; r2 = 0.463, p < 0.01; r2 = 0.461, p < 0.01; r2 = 0.432, p < 0.05).
Conclusions: In short, reported mastication difficulties are prevalent in people with McArdle disease, most frequently in
younger people. Therefore, awareness of mastication and oral motor problems is required
date: 2018-08-02
date_type: published
official_url: https://doi.org/10.3233/JND-180320
oa_status: green
full_text_type: other
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1576611
doi: 10.3233/JND-180320
pii: JND180320
lyricists_name: Quinlivan, Rosaline
lyricists_id: RCMQU67
actors_name: Jayawardana, Anusha
actors_id: AJAYA51
actors_role: owner
full_text_status: public
publication: Journal of Neuromuscular Diseases
volume: 5
number: 3
pagerange: 353-357
event_location: Netherlands
issn: 2214-3599
citation:        Kouwenberg, CV;    Voermans, NC;    Quinlivan, R;    van den Engel-Hoek, L;      (2018)    Mastication and Oral Motor Function in McArdle Disease: Patient Reported Complaints.                   Journal of Neuromuscular Diseases , 5  (3)   pp. 353-357.    10.3233/JND-180320 <https://doi.org/10.3233/JND-180320>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10059493/1/Quinlivan_Mastication%20and%20oral%20motor%20function%20in%20Mc%20Ardle%20disease%2027-03-2018rq.pdf