TY  - JOUR
ID  - discovery10059493
N2  - Background: Exertional myalgia and cramps of the limb and trunk muscles are typical in McArdle disease, but mastication
and oral motor limitations have not been systematically investigated before.
Objective: Determine the reported prevalence and characteristics of limitations on oral motor activities, mastication, swallowing,
and other oral motor activities in patients with McArdle disease.
Methods: An observational study was carried out in 28 patients using a standardised questionnaire on mastication and oral
motor function.
Results: 57% of the participants reported difficulties with mastication. Muscle cramps during mastication occurred in 57%
of the patients. A feeling that food remains in the throat occurred in 32%. Adaptations during mastication were needed in
42% of the patients. Mastication difficulties, muscle cramps during mastication and mastication adjustments were inversely
correlated with age (r2 = ?0.445, p < 0.05; r2 = ?0.509, p < 0.01; r2 = ?0.456, p < 0.05). Feeling of food remaining in throat,
cramps during mastication and during other oral motor muscle activities, were correlated with disease severity (r2 = 0.476,
p < 0.01; r2 = 0.463, p < 0.01; r2 = 0.461, p < 0.01; r2 = 0.432, p < 0.05).
Conclusions: In short, reported mastication difficulties are prevalent in people with McArdle disease, most frequently in
younger people. Therefore, awareness of mastication and oral motor problems is required
KW  - McArdle disease
KW  -  glycogen storage disease type V
KW  -  mastication
KW  -  oral motor function
TI  - Mastication and Oral Motor Function in McArdle Disease: Patient Reported Complaints
EP  - 357
AV  - public
Y1  - 2018/08/02/
SN  - 2214-3599
UR  - https://doi.org/10.3233/JND-180320
JF  - Journal of Neuromuscular Diseases
A1  - Kouwenberg, CV
A1  - Voermans, NC
A1  - Quinlivan, R
A1  - van den Engel-Hoek, L
VL  - 5
SP  - 353
N1  - This version is the author accepted manuscript. For information on re-use, please refer to the publisher?s terms and conditions.
IS  - 3
ER  -