%0 Journal Article
%@ 2214-3599
%A Kouwenberg, CV
%A Voermans, NC
%A Quinlivan, R
%A van den Engel-Hoek, L
%D 2018
%F discovery:10059493
%J Journal of Neuromuscular Diseases
%K McArdle disease, glycogen storage disease type V, mastication, oral motor function
%N 3
%P 353-357
%T Mastication and Oral Motor Function in McArdle Disease: Patient Reported Complaints
%U https://discovery.ucl.ac.uk/id/eprint/10059493/
%V 5
%X Background: Exertional myalgia and cramps of the limb and trunk muscles are typical in McArdle disease, but mastication  and oral motor limitations have not been systematically investigated before.  Objective: Determine the reported prevalence and characteristics of limitations on oral motor activities, mastication, swallowing,  and other oral motor activities in patients with McArdle disease.  Methods: An observational study was carried out in 28 patients using a standardised questionnaire on mastication and oral  motor function.  Results: 57% of the participants reported difficulties with mastication. Muscle cramps during mastication occurred in 57%  of the patients. A feeling that food remains in the throat occurred in 32%. Adaptations during mastication were needed in  42% of the patients. Mastication difficulties, muscle cramps during mastication and mastication adjustments were inversely  correlated with age (r2 = –0.445, p < 0.05; r2 = –0.509, p < 0.01; r2 = –0.456, p < 0.05). Feeling of food remaining in throat,  cramps during mastication and during other oral motor muscle activities, were correlated with disease severity (r2 = 0.476,  p < 0.01; r2 = 0.463, p < 0.01; r2 = 0.461, p < 0.01; r2 = 0.432, p < 0.05).  Conclusions: In short, reported mastication difficulties are prevalent in people with McArdle disease, most frequently in  younger people. Therefore, awareness of mastication and oral motor problems is required
%Z This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.