eprintid: 10059341
rev_number: 27
eprint_status: archive
userid: 608
dir: disk0/10/05/93/41
datestamp: 2018-10-24 08:32:58
lastmod: 2021-09-25 22:57:09
status_changed: 2018-10-24 08:32:58
type: article
metadata_visibility: show
creators_name: Vergallo, A
creators_name: Bun, R-S
creators_name: Toschi, N
creators_name: Baldacci, F
creators_name: Zetterberg, H
creators_name: Blennow, K
creators_name: Cavedo, E
creators_name: Lamari, F
creators_name: Habert, M-O
creators_name: Dubois, B
creators_name: Floris, R
creators_name: Garaci, F
creators_name: Lista, S
creators_name: Hampel, H
creators_name: INSIGHT-preAD study group, 
creators_name: Alzheimer Precision Medicine Initiative (APMI), 
title: Association of Cerebrospinal Fluid Α-synuclein With Total and Phospho-tau181 Protein Concentrations and Brain Amyloid Load in Cognitively Normal Subjective Memory Complainers Stratified by Alzheimer's Disease Biomarkers
ispublished: pub
divisions: UCL
divisions: B02
divisions: C07
divisions: D07
divisions: F86
keywords: Alzheimer's disease, Amyloid PET, Cerebrospinal fluid, Monocentric, Preclinical, SUVR, Subjective memory complainers, Synergistic, Tau protein, α-Synuclein
note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
abstract: INTRODUCTION: Several neurodegenerative brain proteinopathies, including Alzheimer's disease (AD), are associated with cerebral deposition of insoluble aggregates of α-synuclein. Previous studies reported a trend toward increased cerebrospinal fluid (CSF) α-synuclein (α-syn) concentrations in AD compared with other neurodegenerative diseases and healthy controls. METHODS: The pathophysiological role of CSF α-syn in asymptomatic subjects at risk of AD has not been explored. We performed a large-scale cross-sectional observational monocentric study of preclinical individuals at risk for AD (INSIGHT-preAD). RESULTS: We found a positive association between CSF α-syn concentrations and brain β-amyloid deposition measures as mean cortical standard uptake value ratios. We demonstrate positive correlations between CSF α-syn and both CSF t-tau and p-tau181 concentrations. DISCUSSION: Animal models presented evidence, indicating that α-syn may synergistically and directly induce fibrillization of both tau and β-amyloid. Our data indicate an association of CSF α-syn with AD-related pathophysiological mechanisms, during the preclinical phase of the disease.
date: 2018-12
date_type: published
official_url: https://doi.org/10.1016/j.jalz.2018.06.3053
oa_status: green
full_text_type: other
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1576001
doi: 10.1016/j.jalz.2018.06.3053
pii: S1552-5260(18)33241-2
lyricists_name: Zetterberg, Henrik
lyricists_id: HZETT94
actors_name: Jayawardana, Anusha
actors_id: AJAYA51
actors_role: owner
full_text_status: public
publication: Alzheimers Dement
volume: 14
number: 12
pagerange: 1623-1631
event_location: United States
issn: 1552-5279
citation:        Vergallo, A;    Bun, R-S;    Toschi, N;    Baldacci, F;    Zetterberg, H;    Blennow, K;    Cavedo, E;                                     ... Alzheimer Precision Medicine Initiative (APMI); + view all <#>        Vergallo, A;  Bun, R-S;  Toschi, N;  Baldacci, F;  Zetterberg, H;  Blennow, K;  Cavedo, E;  Lamari, F;  Habert, M-O;  Dubois, B;  Floris, R;  Garaci, F;  Lista, S;  Hampel, H;  INSIGHT-preAD study group;  Alzheimer Precision Medicine Initiative (APMI);   - view fewer <#>    (2018)    Association of Cerebrospinal Fluid Α-synuclein With Total and Phospho-tau181 Protein Concentrations and Brain Amyloid Load in Cognitively Normal Subjective Memory Complainers Stratified by Alzheimer's Disease Biomarkers.                   Alzheimers Dement , 14  (12)   pp. 1623-1631.    10.1016/j.jalz.2018.06.3053 <https://doi.org/10.1016/j.jalz.2018.06.3053>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10059341/1/Zetterberg_Vergallo.pdf