%J Alzheimers Dement
%T Association of Cerebrospinal Fluid Α-synuclein With Total and Phospho-tau181 Protein Concentrations and Brain Amyloid Load in Cognitively Normal Subjective Memory Complainers Stratified by Alzheimer's Disease Biomarkers
%A A Vergallo
%A R-S Bun
%A N Toschi
%A F Baldacci
%A H Zetterberg
%A K Blennow
%A E Cavedo
%A F Lamari
%A M-O Habert
%A B Dubois
%A R Floris
%A F Garaci
%A S Lista
%A H Hampel
%A INSIGHT-preAD study group
%A Alzheimer Precision Medicine Initiative (APMI)
%X INTRODUCTION: Several neurodegenerative brain proteinopathies, including Alzheimer's disease (AD), are associated with cerebral deposition of insoluble aggregates of α-synuclein. Previous studies reported a trend toward increased cerebrospinal fluid (CSF) α-synuclein (α-syn) concentrations in AD compared with other neurodegenerative diseases and healthy controls. METHODS: The pathophysiological role of CSF α-syn in asymptomatic subjects at risk of AD has not been explored. We performed a large-scale cross-sectional observational monocentric study of preclinical individuals at risk for AD (INSIGHT-preAD). RESULTS: We found a positive association between CSF α-syn concentrations and brain β-amyloid deposition measures as mean cortical standard uptake value ratios. We demonstrate positive correlations between CSF α-syn and both CSF t-tau and p-tau181 concentrations. DISCUSSION: Animal models presented evidence, indicating that α-syn may synergistically and directly induce fibrillization of both tau and β-amyloid. Our data indicate an association of CSF α-syn with AD-related pathophysiological mechanisms, during the preclinical phase of the disease.
%K Alzheimer's disease, Amyloid PET, Cerebrospinal fluid, Monocentric, Preclinical, SUVR, Subjective memory complainers, Synergistic, Tau protein, α-Synuclein
%L discovery10059341
%N 12
%C United States
%V 14
%D 2018
%O This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
%P 1623-1631