TY  - JOUR
KW  - Alzheimer's disease
KW  -  Amyloid PET
KW  -  Cerebrospinal fluid
KW  -  Monocentric
KW  -  Preclinical
KW  -  SUVR
KW  -  Subjective memory complainers
KW  -  Synergistic
KW  -  Tau protein
KW  -  ?-Synuclein
ID  - discovery10059341
N2  - INTRODUCTION: Several neurodegenerative brain proteinopathies, including Alzheimer's disease (AD), are associated with cerebral deposition of insoluble aggregates of ?-synuclein. Previous studies reported a trend toward increased cerebrospinal fluid (CSF) ?-synuclein (?-syn) concentrations in AD compared with other neurodegenerative diseases and healthy controls. METHODS: The pathophysiological role of CSF ?-syn in asymptomatic subjects at risk of AD has not been explored. We performed a large-scale cross-sectional observational monocentric study of preclinical individuals at risk for AD (INSIGHT-preAD). RESULTS: We found a positive association between CSF ?-syn concentrations and brain ?-amyloid deposition measures as mean cortical standard uptake value ratios. We demonstrate positive correlations between CSF ?-syn and both CSF t-tau and p-tau181 concentrations. DISCUSSION: Animal models presented evidence, indicating that ?-syn may synergistically and directly induce fibrillization of both tau and ?-amyloid. Our data indicate an association of CSF ?-syn with AD-related pathophysiological mechanisms, during the preclinical phase of the disease.
TI  - Association of Cerebrospinal Fluid ?-synuclein With Total and Phospho-tau181 Protein Concentrations and Brain Amyloid Load in Cognitively Normal Subjective Memory Complainers Stratified by Alzheimer's Disease Biomarkers
EP  - 1631
AV  - public
Y1  - 2018/12//
JF  - Alzheimers Dement
A1  - Vergallo, A
A1  - Bun, R-S
A1  - Toschi, N
A1  - Baldacci, F
A1  - Zetterberg, H
A1  - Blennow, K
A1  - Cavedo, E
A1  - Lamari, F
A1  - Habert, M-O
A1  - Dubois, B
A1  - Floris, R
A1  - Garaci, F
A1  - Lista, S
A1  - Hampel, H
A1  - INSIGHT-preAD study group
A1  - Alzheimer Precision Medicine Initiative (APMI)
SN  - 1552-5279
UR  - https://doi.org/10.1016/j.jalz.2018.06.3053
N1  - This version is the author accepted manuscript. For information on re-use, please refer to the publisher?s terms and conditions.
IS  - 12
SP  - 1623
VL  - 14
ER  -