<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> . <> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery.ucl.ac.uk/id/eprint/10059341> . <https://discovery.ucl.ac.uk/id/eprint/10059341> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/AcademicArticle> . <https://discovery.ucl.ac.uk/id/eprint/10059341> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Article> . <https://discovery.ucl.ac.uk/id/eprint/10059341> <http://purl.org/dc/terms/title> "Association of Cerebrospinal Fluid Α-synuclein With Total and Phospho-tau181 Protein Concentrations and Brain Amyloid Load in Cognitively Normal Subjective Memory Complainers Stratified by Alzheimer's Disease Biomarkers"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10059341> <http://purl.org/ontology/bibo/abstract> "INTRODUCTION: Several neurodegenerative brain proteinopathies, including Alzheimer's disease (AD), are associated with cerebral deposition of insoluble aggregates of α-synuclein. Previous studies reported a trend toward increased cerebrospinal fluid (CSF) α-synuclein (α-syn) concentrations in AD compared with other neurodegenerative diseases and healthy controls. METHODS: The pathophysiological role of CSF α-syn in asymptomatic subjects at risk of AD has not been explored. We performed a large-scale cross-sectional observational monocentric study of preclinical individuals at risk for AD (INSIGHT-preAD). RESULTS: We found a positive association between CSF α-syn concentrations and brain β-amyloid deposition measures as mean cortical standard uptake value ratios. We demonstrate positive correlations between CSF α-syn and both CSF t-tau and p-tau181 concentrations. DISCUSSION: Animal models presented evidence, indicating that α-syn may synergistically and directly induce fibrillization of both tau and β-amyloid. Our data indicate an association of CSF α-syn with AD-related pathophysiological mechanisms, during the preclinical phase of the disease."^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10059341> <http://purl.org/dc/terms/date> "2018-12" . <https://discovery.ucl.ac.uk/id/document/763742> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Document> . <https://discovery.ucl.ac.uk/id/eprint/10059341> <http://purl.org/ontology/bibo/volume> "14" . <https://discovery.ucl.ac.uk/id/eprint/10059341> <http://purl.org/ontology/bibo/issue> "12" . <https://discovery.ucl.ac.uk/id/publication/ext-15525279> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Collection> . <https://discovery.ucl.ac.uk/id/publication/ext-15525279> <http://xmlns.com/foaf/0.1/name> "Alzheimers Dement"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10059341> 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<https://discovery.ucl.ac.uk/id/eprint/10059341> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-28a9b6734e25d568a9c408204c759287> . <https://discovery.ucl.ac.uk/id/eprint/10059341> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10059341#authors> . <https://discovery.ucl.ac.uk/id/eprint/10059341#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_2> <https://discovery.ucl.ac.uk/id/person/ext-28a9b6734e25d568a9c408204c759287> . <https://discovery.ucl.ac.uk/id/eprint/10059341> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-0d3103b2613779f3782fc77f49efc7f6> . <https://discovery.ucl.ac.uk/id/eprint/10059341> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10059341#authors> . <https://discovery.ucl.ac.uk/id/eprint/10059341#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_3> <https://discovery.ucl.ac.uk/id/person/ext-0d3103b2613779f3782fc77f49efc7f6> . <https://discovery.ucl.ac.uk/id/eprint/10059341> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-39d27d81275ef424dd236a0f89561757> . <https://discovery.ucl.ac.uk/id/eprint/10059341> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10059341#authors> . <https://discovery.ucl.ac.uk/id/eprint/10059341#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_4> <https://discovery.ucl.ac.uk/id/person/ext-39d27d81275ef424dd236a0f89561757> . <https://discovery.ucl.ac.uk/id/eprint/10059341> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-6040c258716248be5cb4296d4cc94820> . <https://discovery.ucl.ac.uk/id/eprint/10059341> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10059341#authors> . <https://discovery.ucl.ac.uk/id/eprint/10059341#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_5> <https://discovery.ucl.ac.uk/id/person/ext-6040c258716248be5cb4296d4cc94820> . <https://discovery.ucl.ac.uk/id/eprint/10059341> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-256b2a63cf39a40c18ddf50c1ce13671> . <https://discovery.ucl.ac.uk/id/eprint/10059341> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10059341#authors> . <https://discovery.ucl.ac.uk/id/eprint/10059341#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_6> <https://discovery.ucl.ac.uk/id/person/ext-256b2a63cf39a40c18ddf50c1ce13671> . <https://discovery.ucl.ac.uk/id/eprint/10059341> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-7ca1b59c332e2bec4831792233f4096d> . <https://discovery.ucl.ac.uk/id/eprint/10059341> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10059341#authors> . <https://discovery.ucl.ac.uk/id/eprint/10059341#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_7> <https://discovery.ucl.ac.uk/id/person/ext-7ca1b59c332e2bec4831792233f4096d> . <https://discovery.ucl.ac.uk/id/eprint/10059341> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-b07d47c274389ea16caa94507da6fa1a> . <https://discovery.ucl.ac.uk/id/eprint/10059341> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10059341#authors> . <https://discovery.ucl.ac.uk/id/eprint/10059341#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_8> <https://discovery.ucl.ac.uk/id/person/ext-b07d47c274389ea16caa94507da6fa1a> . <https://discovery.ucl.ac.uk/id/eprint/10059341> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-9d9f2c72828262a55b43013404f2bf6c> . <https://discovery.ucl.ac.uk/id/eprint/10059341> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10059341#authors> . <https://discovery.ucl.ac.uk/id/eprint/10059341#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_9> <https://discovery.ucl.ac.uk/id/person/ext-9d9f2c72828262a55b43013404f2bf6c> . <https://discovery.ucl.ac.uk/id/eprint/10059341> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-6823c9345e51240bef2e92b4a32d3ed1> . <https://discovery.ucl.ac.uk/id/eprint/10059341> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10059341#authors> . <https://discovery.ucl.ac.uk/id/eprint/10059341#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_10> <https://discovery.ucl.ac.uk/id/person/ext-6823c9345e51240bef2e92b4a32d3ed1> . <https://discovery.ucl.ac.uk/id/eprint/10059341> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-07d25ff1c1b9d576a734fb7f014466a0> . <https://discovery.ucl.ac.uk/id/eprint/10059341> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10059341#authors> . <https://discovery.ucl.ac.uk/id/eprint/10059341#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_11> <https://discovery.ucl.ac.uk/id/person/ext-07d25ff1c1b9d576a734fb7f014466a0> . <https://discovery.ucl.ac.uk/id/eprint/10059341> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-1c4d232048d38feb4f954d80e679c799> . <https://discovery.ucl.ac.uk/id/eprint/10059341> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10059341#authors> . <https://discovery.ucl.ac.uk/id/eprint/10059341#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_12> <https://discovery.ucl.ac.uk/id/person/ext-1c4d232048d38feb4f954d80e679c799> . <https://discovery.ucl.ac.uk/id/eprint/10059341> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-13f02ec9fb10eed9a914834428c4a385> . <https://discovery.ucl.ac.uk/id/eprint/10059341> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10059341#authors> . <https://discovery.ucl.ac.uk/id/eprint/10059341#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_13> <https://discovery.ucl.ac.uk/id/person/ext-13f02ec9fb10eed9a914834428c4a385> . <https://discovery.ucl.ac.uk/id/eprint/10059341> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-168fc3f37893161a1e7b8f7ee5c02526> . <https://discovery.ucl.ac.uk/id/eprint/10059341> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10059341#authors> . <https://discovery.ucl.ac.uk/id/eprint/10059341#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_14> <https://discovery.ucl.ac.uk/id/person/ext-168fc3f37893161a1e7b8f7ee5c02526> . <https://discovery.ucl.ac.uk/id/eprint/10059341> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-e111b3b2cdc295455b1120e23b413081> . <https://discovery.ucl.ac.uk/id/eprint/10059341> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10059341#authors> . <https://discovery.ucl.ac.uk/id/eprint/10059341#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_15> <https://discovery.ucl.ac.uk/id/person/ext-e111b3b2cdc295455b1120e23b413081> . <https://discovery.ucl.ac.uk/id/eprint/10059341> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-49e8f2cd49aeabedba9e0955c6b75a25> . <https://discovery.ucl.ac.uk/id/eprint/10059341> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10059341#authors> . <https://discovery.ucl.ac.uk/id/eprint/10059341#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_16> <https://discovery.ucl.ac.uk/id/person/ext-49e8f2cd49aeabedba9e0955c6b75a25> . <https://discovery.ucl.ac.uk/id/person/ext-39d27d81275ef424dd236a0f89561757> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-39d27d81275ef424dd236a0f89561757> <http://xmlns.com/foaf/0.1/givenName> "F"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-39d27d81275ef424dd236a0f89561757> <http://xmlns.com/foaf/0.1/familyName> "Baldacci"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-39d27d81275ef424dd236a0f89561757> <http://xmlns.com/foaf/0.1/name> "F Baldacci"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-13f02ec9fb10eed9a914834428c4a385> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-13f02ec9fb10eed9a914834428c4a385> <http://xmlns.com/foaf/0.1/givenName> "S"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-13f02ec9fb10eed9a914834428c4a385> <http://xmlns.com/foaf/0.1/familyName> "Lista"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-13f02ec9fb10eed9a914834428c4a385> <http://xmlns.com/foaf/0.1/name> "S Lista"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-28a9b6734e25d568a9c408204c759287> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . 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