%0 Journal Article
%@ 1552-5279
%A Vergallo, A
%A Bun, R-S
%A Toschi, N
%A Baldacci, F
%A Zetterberg, H
%A Blennow, K
%A Cavedo, E
%A Lamari, F
%A Habert, M-O
%A Dubois, B
%A Floris, R
%A Garaci, F
%A Lista, S
%A Hampel, H
%A INSIGHT-preAD study group
%A Alzheimer Precision Medicine Initiative (APMI)
%D 2018
%F discovery:10059341
%J Alzheimers Dement
%K Alzheimer's disease, Amyloid PET, Cerebrospinal fluid, Monocentric, Preclinical, SUVR, Subjective memory complainers, Synergistic, Tau protein, α-Synuclein
%N 12
%P 1623-1631
%T Association of Cerebrospinal Fluid Α-synuclein With Total and Phospho-tau181 Protein Concentrations and Brain Amyloid Load in Cognitively Normal Subjective Memory Complainers Stratified by Alzheimer's Disease Biomarkers
%U https://discovery.ucl.ac.uk/id/eprint/10059341/
%V 14
%X INTRODUCTION: Several neurodegenerative brain proteinopathies, including Alzheimer's disease (AD), are associated with cerebral deposition of insoluble aggregates of α-synuclein. Previous studies reported a trend toward increased cerebrospinal fluid (CSF) α-synuclein (α-syn) concentrations in AD compared with other neurodegenerative diseases and healthy controls. METHODS: The pathophysiological role of CSF α-syn in asymptomatic subjects at risk of AD has not been explored. We performed a large-scale cross-sectional observational monocentric study of preclinical individuals at risk for AD (INSIGHT-preAD). RESULTS: We found a positive association between CSF α-syn concentrations and brain β-amyloid deposition measures as mean cortical standard uptake value ratios. We demonstrate positive correlations between CSF α-syn and both CSF t-tau and p-tau181 concentrations. DISCUSSION: Animal models presented evidence, indicating that α-syn may synergistically and directly induce fibrillization of both tau and β-amyloid. Our data indicate an association of CSF α-syn with AD-related pathophysiological mechanisms, during the preclinical phase of the disease.
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