@article{discovery10059341,
         journal = {Alzheimers Dement},
           title = {Association of Cerebrospinal Fluid ?-synuclein With Total and Phospho-tau181 Protein Concentrations and Brain Amyloid Load in Cognitively Normal Subjective Memory Complainers Stratified by Alzheimer's Disease Biomarkers},
           pages = {1623--1631},
          volume = {14},
            note = {This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.},
            year = {2018},
          number = {12},
           month = {December},
             url = {https://doi.org/10.1016/j.jalz.2018.06.3053},
            issn = {1552-5279},
        keywords = {Alzheimer's disease, Amyloid PET, Cerebrospinal fluid, Monocentric, Preclinical, SUVR, Subjective memory complainers, Synergistic, Tau protein, {\ensuremath{\alpha}}-Synuclein},
        abstract = {INTRODUCTION: Several neurodegenerative brain proteinopathies, including Alzheimer's disease (AD), are associated with cerebral deposition of insoluble aggregates of {\ensuremath{\alpha}}-synuclein. Previous studies reported a trend toward increased cerebrospinal fluid (CSF) {\ensuremath{\alpha}}-synuclein ({\ensuremath{\alpha}}-syn) concentrations in AD compared with other neurodegenerative diseases and healthy controls. METHODS: The pathophysiological role of CSF {\ensuremath{\alpha}}-syn in asymptomatic subjects at risk of AD has not been explored. We performed a large-scale cross-sectional observational monocentric study of preclinical individuals at risk for AD (INSIGHT-preAD). RESULTS: We found a positive association between CSF {\ensuremath{\alpha}}-syn concentrations and brain {\ensuremath{\beta}}-amyloid deposition measures as mean cortical standard uptake value ratios. We demonstrate positive correlations between CSF {\ensuremath{\alpha}}-syn and both CSF t-tau and p-tau181 concentrations. DISCUSSION: Animal models presented evidence, indicating that {\ensuremath{\alpha}}-syn may synergistically and directly induce fibrillization of both tau and {\ensuremath{\beta}}-amyloid. Our data indicate an association of CSF {\ensuremath{\alpha}}-syn with AD-related pathophysiological mechanisms, during the preclinical phase of the disease.},
          author = {Vergallo, A and Bun, R-S and Toschi, N and Baldacci, F and Zetterberg, H and Blennow, K and Cavedo, E and Lamari, F and Habert, M-O and Dubois, B and Floris, R and Garaci, F and Lista, S and Hampel, H and INSIGHT-preAD study group, {} and Alzheimer Precision Medicine Initiative (APMI), {}}
}