eprintid: 10058342
rev_number: 27
eprint_status: archive
userid: 608
dir: disk0/10/05/83/42
datestamp: 2018-10-15 14:58:05
lastmod: 2021-09-26 23:08:36
status_changed: 2018-10-15 14:58:05
type: article
metadata_visibility: show
creators_name: Panicker, JN
creators_name: Anding, R
creators_name: Arlandis, S
creators_name: Blok, B
creators_name: Dorrepaal, C
creators_name: Harding, C
creators_name: Marcelissen, T
creators_name: Rademakers, K
creators_name: Abrams, P
creators_name: Apostolidis, A
title: Do we understand voiding dysfunction in women? Current understanding and future perspectives: ICI-RS 2017
ispublished: pub
subjects: UCH
divisions: UCL
divisions: B02
divisions: C07
divisions: D07
keywords: Science & Technology, Life Sciences & Biomedicine, Urology & Nephrology, dysfunctional voiding, Fowler's syndrome, opiates, psychological co-morbidities, sacral neuromodulation, sexual abuse, urinary tract infections, voiding dysfunction, URINARY-TRACT SYMPTOMS, BLADDER OUTLET OBSTRUCTION, SACRAL NEUROMODULATION TREATMENT, COMPLEX REPETITIVE DISCHARGES, SEXUAL-ABUSE HISTORY, FEMALE PELVIC FLOOR, DETRUSOR UNDERACTIVITY, FOWLERS-SYNDROME, 3-DIMENSIONAL ULTRASOUND, URETHRAL SPHINCTER
note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
abstract: AIMS:
Urinary retention in women is poorly understood, compared to the equivalent condition in men, and was the subject of a dedicated session organized at the International Consultation on Incontinence Research Society (ICI‐RS) in Bristol, United Kingdom, 2017.

METHODS:
The current understanding of the pathophysiological correlates of idiopathic voiding dysfunction in women, the role of urodynamics, neurophysiology, and non‐invasive tests in characterizing functional bladder outlet obstruction due to a non‐relaxing urethral sphincter, and poorly defined diagnosis of detrusor underactivity were reviewed.

RESULTS:
Putative factors underlying the pathogenesis of urinary retention following urinary tract infections were discussed. Further research is required to explore the association between bladder wall inflammation and alterations in detrusor contractile functions. The complex interrelationship between urinary retention and psychological co‐morbidities and sexual trauma were explored, and the overlap between these and psychological co‐morbidities and functional neurological problems with functional urological problems were recognized. Understanding the mechanism of action of sacral neuromodulation, often a successful treatment for urinary retention, would provide insight into the underlying factors that may be responsible for urinary retention. Specifically, there is a need to understand the role of the endogenous enkephalinergic system in the pathogenesis of urinary retention and to identify predictors of successful treatment with sacral neuromodulation. Based on current understanding and potential directions of research in the future, an algorithm for the evaluation of women with voiding dysfunction was proposed.

CONCLUSIONS:
In the future, recommendations for research should lead to a better understanding of urinary retention in women and its treatment.
date: 2018-06-01
date_type: published
publisher: WILEY
official_url: http://dx.doi.org/10.1002/nau.23709
oa_status: green
full_text_type: other
language: eng
primo: open
primo_central: open_green
article_type_text: Article
verified: verified_manual
elements_id: 1574179
doi: 10.1002/nau.23709
lyricists_name: Panicker, Jalesh
lyricists_id: JPANI24
actors_name: Dewerpe, Marie
actors_id: MDDEW97
actors_role: owner
full_text_status: public
publication: Neurourology and Urodynamics
volume: 37
number: S4
pagerange: S75-S85
pages: 11
issn: 1520-6777
citation:        Panicker, JN;    Anding, R;    Arlandis, S;    Blok, B;    Dorrepaal, C;    Harding, C;    Marcelissen, T;             ... Apostolidis, A; + view all <#>        Panicker, JN;  Anding, R;  Arlandis, S;  Blok, B;  Dorrepaal, C;  Harding, C;  Marcelissen, T;  Rademakers, K;  Abrams, P;  Apostolidis, A;   - view fewer <#>    (2018)    Do we understand voiding dysfunction in women? Current understanding and future perspectives: ICI-RS 2017.                   Neurourology and Urodynamics , 37  (S4)   S75-S85.    10.1002/nau.23709 <https://doi.org/10.1002/nau.23709>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10058342/3/Panicker_CLEANVERSIONrevisedfFinalFemalevoidingdysfunction10.01.18_.pdf