<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> .
<> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery.ucl.ac.uk/id/eprint/10058278> .
<https://discovery.ucl.ac.uk/id/eprint/10058278> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/AcademicArticle> .
<https://discovery.ucl.ac.uk/id/eprint/10058278> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Article> .
<https://discovery.ucl.ac.uk/id/eprint/10058278> <http://purl.org/dc/terms/title> "Interlaboratory Validation of Cerebrospinal Fluid Α-synuclein Quantification in the Diagnosis of Sporadic Creutzfeldt-jakob Disease"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10058278> <http://purl.org/ontology/bibo/abstract> "INTRODUCTION:\r\nCerebrospinal fluid α-synuclein level is increased in sporadic Creutzfeldt-Jakob disease cases. However, the clinical value of this biomarker remains to be established. In this study, we have addressed the clinical validation parameters and the interlaboratory reproducibility by using an electrochemiluminescent assay.\r\n\r\nMETHODS\r\nCerebrospinal fluid α-synuclein was quantified in a total of 188 sporadic Creutzfeldt-Jakob disease and non–Creutzfeldt-Jakob-disease cases to determine sensitivity and specificity values and lot-to-lot variability. Two round robin tests with 70 additional cases were performed in six independent laboratories.\r\n\r\nRESULTS:\r\nA sensitivity of 93% and a specificity of 96% were achieved in discriminating sporadic Creutzfeldt-Jakob disease. No differences were detected between lots. The mean interlaboratory coefficient of variation was 23%, and the intralaboratory coefficient of variations ranged 2.70%–11.39%. Overall, 97% of samples were correctly diagnosed.\r\n\r\nDISCUSSION:\r\nThe herein validated α-synuclein assay is robust, accurate, and reproducible in identifying Creutzfeldt-Jakob disease cases. Thus, it is ready for implementation in the clinical practice to support the diagnosis of Creutzfeldt-Jakob disease."^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10058278> <http://purl.org/dc/terms/date> "2018-07-07" .
<https://discovery.ucl.ac.uk/id/document/752894> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Document> .
<https://discovery.ucl.ac.uk/id/eprint/10058278> <http://purl.org/ontology/bibo/volume> "10" .
<https://discovery.ucl.ac.uk/id/publication/ext-23528729> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Collection> .
<https://discovery.ucl.ac.uk/id/publication/ext-23528729> <http://xmlns.com/foaf/0.1/name> "Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10058278> <http://purl.org/dc/terms/isPartOf> <https://discovery.ucl.ac.uk/id/publication/ext-23528729> .
<https://discovery.ucl.ac.uk/id/publication/ext-23528729> <http://www.w3.org/2002/07/owl#sameAs> <urn:issn:23528729> .
<https://discovery.ucl.ac.uk/id/publication/ext-23528729> <http://purl.org/ontology/bibo/issn> "23528729" .
<https://discovery.ucl.ac.uk/id/eprint/10058278> <http://purl.org/ontology/bibo/status> <http://purl.org/ontology/bibo/status/published> .
<https://discovery.ucl.ac.uk/id/eprint/10058278> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-4a8e12c98983c90ddf40e7f7add7e5d0> .
<https://discovery.ucl.ac.uk/id/eprint/10058278> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10058278#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10058278#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_1> <https://discovery.ucl.ac.uk/id/person/ext-4a8e12c98983c90ddf40e7f7add7e5d0> .
<https://discovery.ucl.ac.uk/id/eprint/10058278> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-5c096d7ef92dde6af52d83ce6253ca79> .
<https://discovery.ucl.ac.uk/id/eprint/10058278> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10058278#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10058278#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_2> <https://discovery.ucl.ac.uk/id/person/ext-5c096d7ef92dde6af52d83ce6253ca79> .
<https://discovery.ucl.ac.uk/id/eprint/10058278> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-61854413af28ce91696fc80e3f1402c2> .
<https://discovery.ucl.ac.uk/id/eprint/10058278> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10058278#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10058278#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_3> <https://discovery.ucl.ac.uk/id/person/ext-61854413af28ce91696fc80e3f1402c2> .
<https://discovery.ucl.ac.uk/id/eprint/10058278> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-42d22cfcf3f2aa7631e434982c399568> .
<https://discovery.ucl.ac.uk/id/eprint/10058278> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10058278#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10058278#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_4> <https://discovery.ucl.ac.uk/id/person/ext-42d22cfcf3f2aa7631e434982c399568> .
<https://discovery.ucl.ac.uk/id/eprint/10058278> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-35c2923351fc4135f665c6b18c028b25> .
<https://discovery.ucl.ac.uk/id/eprint/10058278> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10058278#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10058278#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_5> <https://discovery.ucl.ac.uk/id/person/ext-35c2923351fc4135f665c6b18c028b25> .
<https://discovery.ucl.ac.uk/id/eprint/10058278> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-5b28bb13e6be6748dd4ad697ead8cf3a> .
<https://discovery.ucl.ac.uk/id/eprint/10058278> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10058278#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10058278#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_6> <https://discovery.ucl.ac.uk/id/person/ext-5b28bb13e6be6748dd4ad697ead8cf3a> .
<https://discovery.ucl.ac.uk/id/eprint/10058278> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-d0fd3662066c838018c4be1cdae16586> .
<https://discovery.ucl.ac.uk/id/eprint/10058278> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10058278#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10058278#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_7> <https://discovery.ucl.ac.uk/id/person/ext-d0fd3662066c838018c4be1cdae16586> .
<https://discovery.ucl.ac.uk/id/eprint/10058278> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-2c0c10d0cf05f4d5fe4fab262f5177dc> .
<https://discovery.ucl.ac.uk/id/eprint/10058278> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10058278#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10058278#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_8> <https://discovery.ucl.ac.uk/id/person/ext-2c0c10d0cf05f4d5fe4fab262f5177dc> .
<https://discovery.ucl.ac.uk/id/eprint/10058278> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-fb1d5343429376540ec5d9a5b9aaae80> .
<https://discovery.ucl.ac.uk/id/eprint/10058278> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10058278#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10058278#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_9> <https://discovery.ucl.ac.uk/id/person/ext-fb1d5343429376540ec5d9a5b9aaae80> .
<https://discovery.ucl.ac.uk/id/eprint/10058278> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-d21b55fe33d7f39c117f1430c85a0028> .
<https://discovery.ucl.ac.uk/id/eprint/10058278> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10058278#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10058278#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_10> <https://discovery.ucl.ac.uk/id/person/ext-d21b55fe33d7f39c117f1430c85a0028> .
<https://discovery.ucl.ac.uk/id/eprint/10058278> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-1d216ff4e630862be4452da4afeb5ff9> .
<https://discovery.ucl.ac.uk/id/eprint/10058278> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10058278#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10058278#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_11> <https://discovery.ucl.ac.uk/id/person/ext-1d216ff4e630862be4452da4afeb5ff9> .
<https://discovery.ucl.ac.uk/id/eprint/10058278> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-d535168a9ee281d22377fe145dfde86b> .
<https://discovery.ucl.ac.uk/id/eprint/10058278> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10058278#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10058278#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_12> <https://discovery.ucl.ac.uk/id/person/ext-d535168a9ee281d22377fe145dfde86b> .
<https://discovery.ucl.ac.uk/id/eprint/10058278> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-b9e945a0b99905370ae884a9c81fa775> .
<https://discovery.ucl.ac.uk/id/eprint/10058278> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10058278#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10058278#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_13> <https://discovery.ucl.ac.uk/id/person/ext-b9e945a0b99905370ae884a9c81fa775> .
<https://discovery.ucl.ac.uk/id/person/ext-d21b55fe33d7f39c117f1430c85a0028> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-d21b55fe33d7f39c117f1430c85a0028> <http://xmlns.com/foaf/0.1/givenName> "H"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-d21b55fe33d7f39c117f1430c85a0028> <http://xmlns.com/foaf/0.1/familyName> "Zetterberg"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-d21b55fe33d7f39c117f1430c85a0028> <http://xmlns.com/foaf/0.1/name> "H Zetterberg"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-35c2923351fc4135f665c6b18c028b25> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-35c2923351fc4135f665c6b18c028b25> <http://xmlns.com/foaf/0.1/givenName> "A"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-35c2923351fc4135f665c6b18c028b25> <http://xmlns.com/foaf/0.1/familyName> "Villar-Piqué"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-35c2923351fc4135f665c6b18c028b25> <http://xmlns.com/foaf/0.1/name> "A Villar-Piqué"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-5c096d7ef92dde6af52d83ce6253ca79> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-5c096d7ef92dde6af52d83ce6253ca79> <http://xmlns.com/foaf/0.1/givenName> "A"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-5c096d7ef92dde6af52d83ce6253ca79> <http://xmlns.com/foaf/0.1/familyName> "Heslegrave"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-5c096d7ef92dde6af52d83ce6253ca79> <http://xmlns.com/foaf/0.1/name> "A Heslegrave"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-61854413af28ce91696fc80e3f1402c2> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-61854413af28ce91696fc80e3f1402c2> <http://xmlns.com/foaf/0.1/givenName> "V"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-61854413af28ce91696fc80e3f1402c2> <http://xmlns.com/foaf/0.1/familyName> "Gupta"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-61854413af28ce91696fc80e3f1402c2> <http://xmlns.com/foaf/0.1/name> "V Gupta"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-d0fd3662066c838018c4be1cdae16586> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-d0fd3662066c838018c4be1cdae16586> <http://xmlns.com/foaf/0.1/givenName> "S"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-d0fd3662066c838018c4be1cdae16586> <http://xmlns.com/foaf/0.1/familyName> "Lehmann"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-d0fd3662066c838018c4be1cdae16586> <http://xmlns.com/foaf/0.1/name> "S Lehmann"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-fb1d5343429376540ec5d9a5b9aaae80> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-fb1d5343429376540ec5d9a5b9aaae80> <http://xmlns.com/foaf/0.1/givenName> "K"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-fb1d5343429376540ec5d9a5b9aaae80> <http://xmlns.com/foaf/0.1/familyName> "Blennow"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-fb1d5343429376540ec5d9a5b9aaae80> <http://xmlns.com/foaf/0.1/name> "K Blennow"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-1d216ff4e630862be4452da4afeb5ff9> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-1d216ff4e630862be4452da4afeb5ff9> <http://xmlns.com/foaf/0.1/givenName> "B"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-1d216ff4e630862be4452da4afeb5ff9> <http://xmlns.com/foaf/0.1/familyName> "Mollenhauer"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-1d216ff4e630862be4452da4afeb5ff9> <http://xmlns.com/foaf/0.1/name> "B Mollenhauer"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-d535168a9ee281d22377fe145dfde86b> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-d535168a9ee281d22377fe145dfde86b> <http://xmlns.com/foaf/0.1/givenName> "I"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-d535168a9ee281d22377fe145dfde86b> <http://xmlns.com/foaf/0.1/familyName> "Zerr"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-d535168a9ee281d22377fe145dfde86b> <http://xmlns.com/foaf/0.1/name> "I Zerr"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-42d22cfcf3f2aa7631e434982c399568> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-42d22cfcf3f2aa7631e434982c399568> <http://xmlns.com/foaf/0.1/givenName> "M"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-42d22cfcf3f2aa7631e434982c399568> <http://xmlns.com/foaf/0.1/familyName> "Foiani"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-42d22cfcf3f2aa7631e434982c399568> <http://xmlns.com/foaf/0.1/name> "M Foiani"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-2c0c10d0cf05f4d5fe4fab262f5177dc> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-2c0c10d0cf05f4d5fe4fab262f5177dc> <http://xmlns.com/foaf/0.1/givenName> "C"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-2c0c10d0cf05f4d5fe4fab262f5177dc> <http://xmlns.com/foaf/0.1/familyName> "Teunissen"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-2c0c10d0cf05f4d5fe4fab262f5177dc> <http://xmlns.com/foaf/0.1/name> "C Teunissen"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-b9e945a0b99905370ae884a9c81fa775> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-b9e945a0b99905370ae884a9c81fa775> <http://xmlns.com/foaf/0.1/givenName> "F"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-b9e945a0b99905370ae884a9c81fa775> <http://xmlns.com/foaf/0.1/familyName> "Llorens"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-b9e945a0b99905370ae884a9c81fa775> <http://xmlns.com/foaf/0.1/name> "F Llorens"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-4a8e12c98983c90ddf40e7f7add7e5d0> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-4a8e12c98983c90ddf40e7f7add7e5d0> <http://xmlns.com/foaf/0.1/givenName> "N"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-4a8e12c98983c90ddf40e7f7add7e5d0> <http://xmlns.com/foaf/0.1/familyName> "Kruse"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-4a8e12c98983c90ddf40e7f7add7e5d0> <http://xmlns.com/foaf/0.1/name> "N Kruse"^^<http://www.w3.org/2001/XMLSchema#string> .
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