eprintid: 10057923
rev_number: 20
eprint_status: archive
userid: 608
dir: disk0/10/05/79/23
datestamp: 2018-10-09 12:15:53
lastmod: 2021-09-20 22:21:45
status_changed: 2018-10-09 12:15:53
type: article
metadata_visibility: show
creators_name: Osborn, KE
creators_name: Liu, D
creators_name: Samuels, LR
creators_name: Moore, EE
creators_name: Cambronero, FE
creators_name: Acosta, LMY
creators_name: Bell, SP
creators_name: Babicz, MA
creators_name: Gordon, EA
creators_name: Pechman, KR
creators_name: Davis, LT
creators_name: Gifford, KA
creators_name: Hohman, TJ
creators_name: Blennow, K
creators_name: Zetterberg, H
creators_name: Jefferson, AL
title: Cerebrospinal fluid β-amyloid₄₂ and neurofilament light relate to white matter hyperintensities
ispublished: pub
divisions: UCL
divisions: B02
divisions: C07
divisions: D07
divisions: F86
keywords: Cerebrospinal fluid, Dementia, White matter hyperintensities, Amyloid, β-amyloid₄₂, Neurofilament light
note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
abstract: White matter hyperintensities (WMHs) are associated with poorer brain health, but their pathophysiological substrates remain elusive. To better understand the mechanistic underpinnings of WMHs among older adults, this study examined in vivo cerebrospinal fluid biomarkers of β-amyloid₄₂ deposition (Aβ₄₂), hyperphosphorylated tau pathology, neurodegeneration (total tau), and axonal injury (neurofilament light [NFL]) in relation to log-transformed WMHs volume. Participants free of clinical stroke and dementia were drawn from the Vanderbilt Memory & Aging Project (n = 148, 72 ± 6 years). Linear regression models adjusted for age, sex, race/ethnicity, education, intracranial volume, modified Framingham Stroke Risk Profile (excluding points assigned for age), cognitive diagnosis, and APOE-ε4 carrier status. Aβ₄₂ (β = −0.001, p = 0.007) and NFL (β = 0.0003, p = 0.01) concentrations related to WMHs but neither hyperphosphorylated tau nor total tau associations with WMHs reached statistical significance (p-values > 0.21). In a combined model, NFL accounted for 3.2% of unique variance in WMHs and Aβ₄₂ accounted for an additional 4.3% beyond NFL, providing novel evidence of the co-occurrence of at least 2 distinct pathways for WMHs among older adults, including amyloid deposition and axonal injury.
date: 2018-08
date_type: published
publisher: ELSEVIER SCIENCE INC
official_url: https://doi.org/10.1016/j.neurobiolaging.2018.03.028
oa_status: green
full_text_type: other
language: eng
primo: open
primo_central: open_green
article_type_text: Journal Article
verified: verified_manual
elements_id: 1553517
doi: 10.1016/j.neurobiolaging.2018.03.028
language_elements: English
lyricists_name: Zetterberg, Henrik
lyricists_id: HZETT94
actors_name: Zetterberg, Henrik
actors_name: Harriot, Anne-Marie
actors_id: HZETT94
actors_id: AHARA72
actors_role: owner
actors_role: impersonator
full_text_status: public
publication: Neurobiology of Aging
volume: 68
pagerange: 18-25
pages: 8
issn: 0197-4580
citation:        Osborn, KE;    Liu, D;    Samuels, LR;    Moore, EE;    Cambronero, FE;    Acosta, LMY;    Bell, SP;                                     ... Jefferson, AL; + view all <#>        Osborn, KE;  Liu, D;  Samuels, LR;  Moore, EE;  Cambronero, FE;  Acosta, LMY;  Bell, SP;  Babicz, MA;  Gordon, EA;  Pechman, KR;  Davis, LT;  Gifford, KA;  Hohman, TJ;  Blennow, K;  Zetterberg, H;  Jefferson, AL;   - view fewer <#>    (2018)    Cerebrospinal fluid β-amyloid₄₂ and neurofilament light relate to white matter hyperintensities.                   Neurobiology of Aging , 68    pp. 18-25.    10.1016/j.neurobiolaging.2018.03.028 <https://doi.org/10.1016/j.neurobiolaging.2018.03.028>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10057923/1/Zetterberg_Cerebrospinal%20fluid%20%CE%B2-amyloid%E2%82%84%E2%82%82%20and%20neurofilament%20light%20relate%20to%20white%20matter%20hyperintensities_AAM.pdf