TY  - JOUR
N1  - This version is the author accepted manuscript. For information on re-use, please refer to the publisher?s terms and conditions.
VL  - 68
SP  - 18
JF  - Neurobiology of Aging
A1  - Osborn, KE
A1  - Liu, D
A1  - Samuels, LR
A1  - Moore, EE
A1  - Cambronero, FE
A1  - Acosta, LMY
A1  - Bell, SP
A1  - Babicz, MA
A1  - Gordon, EA
A1  - Pechman, KR
A1  - Davis, LT
A1  - Gifford, KA
A1  - Hohman, TJ
A1  - Blennow, K
A1  - Zetterberg, H
A1  - Jefferson, AL
UR  - https://doi.org/10.1016/j.neurobiolaging.2018.03.028
SN  - 0197-4580
TI  - Cerebrospinal fluid ?-amyloid?? and neurofilament light relate to white matter hyperintensities
AV  - public
Y1  - 2018/08//
EP  - 25
KW  - Cerebrospinal fluid
KW  -  Dementia
KW  -  White matter hyperintensities
KW  -  Amyloid
KW  -  ?-amyloid??
KW  -  Neurofilament light
N2  - White matter hyperintensities (WMHs) are associated with poorer brain health, but their pathophysiological substrates remain elusive. To better understand the mechanistic underpinnings of WMHs among older adults, this study examined in vivo cerebrospinal fluid biomarkers of ?-amyloid?? deposition (A???), hyperphosphorylated tau pathology, neurodegeneration (total tau), and axonal injury (neurofilament light [NFL]) in relation to log-transformed WMHs volume. Participants free of clinical stroke and dementia were drawn from the Vanderbilt Memory & Aging Project (n = 148, 72 ą 6 years). Linear regression models adjusted for age, sex, race/ethnicity, education, intracranial volume, modified Framingham Stroke Risk Profile (excluding points assigned for age), cognitive diagnosis, and APOE-?4 carrier status. A??? (? = ?0.001, p = 0.007) and NFL (? = 0.0003, p = 0.01) concentrations related to WMHs but neither hyperphosphorylated tau nor total tau associations with WMHs reached statistical significance (p-values > 0.21). In a combined model, NFL accounted for 3.2% of unique variance in WMHs and A??? accounted for an additional 4.3% beyond NFL, providing novel evidence of the co-occurrence of at least 2 distinct pathways for WMHs among older adults, including amyloid deposition and axonal injury.
ID  - discovery10057923
PB  - ELSEVIER SCIENCE INC
ER  -