eprintid: 10057804 rev_number: 27 eprint_status: archive userid: 608 dir: disk0/10/05/78/04 datestamp: 2018-10-08 13:59:14 lastmod: 2021-09-23 22:37:12 status_changed: 2018-10-08 13:59:14 type: article metadata_visibility: show creators_name: Gilson, M creators_name: Deco, G creators_name: Friston, KJ creators_name: Hagmann, P creators_name: Mantini, D creators_name: Betti, V creators_name: Romani, GL creators_name: Corbetta, M title: Effective connectivity inferred from fMRI transition dynamics during movie viewing points to a balanced reconfiguration of cortical interactions ispublished: pub divisions: UCL divisions: B02 divisions: C07 divisions: D07 divisions: F83 keywords: Science & Technology, Life Sciences & Biomedicine, Neurosciences, Neuroimaging, Radiology, Nuclear Medicine & Medical Imaging, Neurosciences & Neurology, RESTING-STATE FMRI, FUNCTIONAL CONNECTIVITY, HUMAN BRAIN, NETWORKS, OSCILLATIONS, NOISE, TASK, MRI, SYNCHRONIZATION, ARCHITECTURES note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. abstract: Our behavior entails a flexible and context-sensitive interplay between brain areas to integrate information according to goal-directed requirements. However, the neural mechanisms governing the entrainment of functionally specialized brain areas remain poorly understood. In particular, the question arises whether observed changes in the regional activity for different cognitive conditions are explained by modifications of the inputs to the brain or its connectivity? We observe that transitions of fMRI activity between areas convey information about the tasks performed by 19 subjects, watching a movie versus a black screen (rest). We use a model-based framework that explains this spatiotemporal functional connectivity pattern by the local variability for 66 cortical regions and the network effective connectivity between them. We find that, among the estimated model parameters, movie viewing affects to a larger extent the local activity, which we interpret as extrinsic changes related to the increased stimulus load. However, detailed changes in the effective connectivity preserve a balance in the propagating activity and select specific pathways such that high-level brain regions integrate visual and auditory information, in particular boosting the communication between the two brain hemispheres. These findings speak to a dynamic coordination underlying the functional integration in the brain. date: 2018-10-15 date_type: published publisher: ACADEMIC PRESS INC ELSEVIER SCIENCE official_url: http://dx.doi.org/10.1016/j.neuroimage.2017.09.061 oa_status: green full_text_type: other language: eng primo: open primo_central: open_green article_type_text: Review verified: verified_manual elements_id: 1506791 doi: 10.1016/j.neuroimage.2017.09.061 lyricists_name: Friston, Karl lyricists_id: KJFRI52 actors_name: Dewerpe, Marie actors_id: MDDEW97 actors_role: owner full_text_status: public publication: NeuroImage volume: 180 pagerange: 534-546 pages: 13 issn: 1095-9572 citation: Gilson, M; Deco, G; Friston, KJ; Hagmann, P; Mantini, D; Betti, V; Romani, GL; Gilson, M; Deco, G; Friston, KJ; Hagmann, P; Mantini, D; Betti, V; Romani, GL; Corbetta, M; - view fewer <#> (2018) Effective connectivity inferred from fMRI transition dynamics during movie viewing points to a balanced reconfiguration of cortical interactions. NeuroImage , 180 pp. 534-546. 10.1016/j.neuroimage.2017.09.061 <https://doi.org/10.1016/j.neuroimage.2017.09.061>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10057804/5/Friston_Gilson_movie_DM_combined.pdf