eprintid: 10057804
rev_number: 27
eprint_status: archive
userid: 608
dir: disk0/10/05/78/04
datestamp: 2018-10-08 13:59:14
lastmod: 2021-09-23 22:37:12
status_changed: 2018-10-08 13:59:14
type: article
metadata_visibility: show
creators_name: Gilson, M
creators_name: Deco, G
creators_name: Friston, KJ
creators_name: Hagmann, P
creators_name: Mantini, D
creators_name: Betti, V
creators_name: Romani, GL
creators_name: Corbetta, M
title: Effective connectivity inferred from fMRI transition dynamics during movie viewing points to a balanced reconfiguration of cortical interactions
ispublished: pub
divisions: UCL
divisions: B02
divisions: C07
divisions: D07
divisions: F83
keywords: Science & Technology, Life Sciences & Biomedicine, Neurosciences, Neuroimaging, Radiology, Nuclear Medicine & Medical Imaging, Neurosciences & Neurology, RESTING-STATE FMRI, FUNCTIONAL CONNECTIVITY, HUMAN BRAIN, NETWORKS, OSCILLATIONS, NOISE, TASK, MRI, SYNCHRONIZATION, ARCHITECTURES
note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
abstract: Our behavior entails a flexible and context-sensitive interplay between brain areas to integrate information according to goal-directed requirements. However, the neural mechanisms governing the entrainment of functionally specialized brain areas remain poorly understood. In particular, the question arises whether observed changes in the regional activity for different cognitive conditions are explained by modifications of the inputs to the brain or its connectivity? We observe that transitions of fMRI activity between areas convey information about the tasks performed by 19 subjects, watching a movie versus a black screen (rest). We use a model-based framework that explains this spatiotemporal functional connectivity pattern by the local variability for 66 cortical regions and the network effective connectivity between them. We find that, among the estimated model parameters, movie viewing affects to a larger extent the local activity, which we interpret as extrinsic changes related to the increased stimulus load. However, detailed changes in the effective connectivity preserve a balance in the propagating activity and select specific pathways such that high-level brain regions integrate visual and auditory information, in particular boosting the communication between the two brain hemispheres. These findings speak to a dynamic coordination underlying the functional integration in the brain.
date: 2018-10-15
date_type: published
publisher: ACADEMIC PRESS INC ELSEVIER SCIENCE
official_url: http://dx.doi.org/10.1016/j.neuroimage.2017.09.061
oa_status: green
full_text_type: other
language: eng
primo: open
primo_central: open_green
article_type_text: Review
verified: verified_manual
elements_id: 1506791
doi: 10.1016/j.neuroimage.2017.09.061
lyricists_name: Friston, Karl
lyricists_id: KJFRI52
actors_name: Dewerpe, Marie
actors_id: MDDEW97
actors_role: owner
full_text_status: public
publication: NeuroImage
volume: 180
pagerange: 534-546
pages: 13
issn: 1095-9572
citation:        Gilson, M;    Deco, G;    Friston, KJ;    Hagmann, P;    Mantini, D;    Betti, V;    Romani, GL;           Gilson, M;  Deco, G;  Friston, KJ;  Hagmann, P;  Mantini, D;  Betti, V;  Romani, GL;  Corbetta, M;   - view fewer <#>    (2018)    Effective connectivity inferred from fMRI transition dynamics during movie viewing points to a balanced reconfiguration of cortical interactions.                   NeuroImage , 180    pp. 534-546.    10.1016/j.neuroimage.2017.09.061 <https://doi.org/10.1016/j.neuroimage.2017.09.061>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10057804/5/Friston_Gilson_movie_DM_combined.pdf