Woodward, HL;    Innocenti, P;    Cheung, KMJ;    Hayes, A;    Roberts, J;    Henley, AT;    Faisal, A;                                                                         ... Hoelder, S; + view all <#>        Woodward, HL;  Innocenti, P;  Cheung, KMJ;  Hayes, A;  Roberts, J;  Henley, AT;  Faisal, A;  Mak, GWY;  Box, G;  Westwood, IM;  Cronin, N;  Carter, M;  Valenti, M;  De Haven Brandon, A;  O'Fee, L;  Saville, H;  Schmitt, J;  Burke, R;  Broccatelli, F;  Van Montfort, RLM;  Raynaud, FI;  Eccles, SA;  Linardopoulos, S;  Blagg, J;  Hoelder, S;   - view fewer <#>    (2018)    Introduction of a Methyl Group Curbs Metabolism of Pyrido[3,4-d]pyrimidine Monopolar Spindle 1 (MPS1) Inhibitors and Enables the Discovery of the Phase 1 Clinical Candidate N2-(2-Ethoxy-4-(4-methyl-4H-1,2,4-triazol-3-yl)phenyl)-6-methyl-N8-neopentylpyrido[3,4-d]pyrimidine-2,8-diamine (BOS172722).                   Journal of Medicinal Chemistry , 61  (18)   pp. 8226-8240.    10.1021/acs.jmedchem.8b00690 <https://doi.org/10.1021/acs.jmedchem.8b00690>.       Green open access