<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> .
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<https://discovery.ucl.ac.uk/id/eprint/10057245> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Article> .
<https://discovery.ucl.ac.uk/id/eprint/10057245> <http://purl.org/dc/terms/title> "Introduction of a Methyl Group Curbs Metabolism of Pyrido[3,4-d]pyrimidine Monopolar Spindle 1 (MPS1) Inhibitors and Enables the Discovery of the Phase 1 Clinical Candidate N2-(2-Ethoxy-4-(4-methyl-4H-1,2,4-triazol-3-yl)phenyl)-6-methyl-N8-neopentylpyrido[3,4-d]pyrimidine-2,8-diamine (BOS172722)"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10057245> <http://purl.org/ontology/bibo/abstract> "Monopolar spindle 1 (MPS1) occupies a central role in mitosis and is one of the main components of the spindle assembly checkpoint. The MPS1 kinase is an attractive cancer target, and herein, we report the discovery of the clinical candidate BOS172722. The starting point for our work was a series of pyrido[3,4-d]pyrimidine inhibitors that demonstrated excellent potency and kinase selectivity but suffered from rapid turnover in human liver microsomes (HLM). Optimizing HLM stability proved challenging since it was not possible to identify a consistent site of metabolism and lowering lipophilicity proved unsuccessful. Key to overcoming this problem was the finding that introduction of a methyl group at the 6-position of the pyrido[3,4-d]pyrimidine core significantly improved HLM stability. Met ID studies suggested that the methyl group suppressed metabolism at the distant aniline portion of the molecule, likely by blocking the preferred pharmacophore through which P450 recognized the compound. This work ultimately led to the discovery of BOS172722 as a Phase 1 clinical candidate."^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10057245> <http://purl.org/dc/terms/date> "2018-09-27" .
<https://discovery.ucl.ac.uk/id/document/743948> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Document> .
<https://discovery.ucl.ac.uk/id/eprint/10057245> <http://purl.org/ontology/bibo/volume> "61" .
<https://discovery.ucl.ac.uk/id/eprint/10057245> <http://purl.org/ontology/bibo/issue> "18" .
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<https://discovery.ucl.ac.uk/id/publication/ext-15204804> <http://xmlns.com/foaf/0.1/name> "Journal of Medicinal Chemistry"^^<http://www.w3.org/2001/XMLSchema#string> .
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<https://discovery.ucl.ac.uk/id/publication/ext-15204804> <http://purl.org/ontology/bibo/issn> "15204804" .
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<https://discovery.ucl.ac.uk/id/eprint/10057245> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10057245#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10057245#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_1> <https://discovery.ucl.ac.uk/id/person/ext-1930895ef245aeb475bd9254e6381244> .
<https://discovery.ucl.ac.uk/id/eprint/10057245> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-962ab330cf148f9347c74467ce159409> .
<https://discovery.ucl.ac.uk/id/eprint/10057245> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10057245#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10057245#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_2> <https://discovery.ucl.ac.uk/id/person/ext-962ab330cf148f9347c74467ce159409> .
<https://discovery.ucl.ac.uk/id/eprint/10057245> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-83d86b788ed7a51f3b8a49cf0e8abaa9> .
<https://discovery.ucl.ac.uk/id/eprint/10057245> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10057245#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10057245#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_3> <https://discovery.ucl.ac.uk/id/person/ext-83d86b788ed7a51f3b8a49cf0e8abaa9> .
<https://discovery.ucl.ac.uk/id/eprint/10057245> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-4e4d8a1da9f3c822563ba2f15a23b1c1> .
<https://discovery.ucl.ac.uk/id/eprint/10057245> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10057245#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10057245#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_4> <https://discovery.ucl.ac.uk/id/person/ext-4e4d8a1da9f3c822563ba2f15a23b1c1> .
<https://discovery.ucl.ac.uk/id/eprint/10057245> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-1e61e764668b2cfe2c84f3c6006ece31> .
<https://discovery.ucl.ac.uk/id/eprint/10057245> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10057245#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10057245#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_5> <https://discovery.ucl.ac.uk/id/person/ext-1e61e764668b2cfe2c84f3c6006ece31> .
<https://discovery.ucl.ac.uk/id/eprint/10057245> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-74f69fc049e1c5b1e7572847ab17c169> .
<https://discovery.ucl.ac.uk/id/eprint/10057245> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10057245#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10057245#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_6> <https://discovery.ucl.ac.uk/id/person/ext-74f69fc049e1c5b1e7572847ab17c169> .
<https://discovery.ucl.ac.uk/id/eprint/10057245> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-46b3fc4ec8f14b55779ae1df5c205fab> .
<https://discovery.ucl.ac.uk/id/eprint/10057245> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10057245#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10057245#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_7> <https://discovery.ucl.ac.uk/id/person/ext-46b3fc4ec8f14b55779ae1df5c205fab> .
<https://discovery.ucl.ac.uk/id/eprint/10057245> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-4d49847ea96d0c5fa567d6117ad7d411> .
<https://discovery.ucl.ac.uk/id/eprint/10057245> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10057245#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10057245#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_8> <https://discovery.ucl.ac.uk/id/person/ext-4d49847ea96d0c5fa567d6117ad7d411> .
<https://discovery.ucl.ac.uk/id/eprint/10057245> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-f1d7f0ac06a79f89abd1b73407285e92> .
<https://discovery.ucl.ac.uk/id/eprint/10057245> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10057245#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10057245#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_9> <https://discovery.ucl.ac.uk/id/person/ext-f1d7f0ac06a79f89abd1b73407285e92> .
<https://discovery.ucl.ac.uk/id/eprint/10057245> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-6a41a6f99fadfac82820d2df00621c59> .
<https://discovery.ucl.ac.uk/id/eprint/10057245> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10057245#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10057245#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_10> <https://discovery.ucl.ac.uk/id/person/ext-6a41a6f99fadfac82820d2df00621c59> .
<https://discovery.ucl.ac.uk/id/eprint/10057245> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-eac8846101c635ae1b69f470f7fbe882> .
<https://discovery.ucl.ac.uk/id/eprint/10057245> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10057245#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10057245#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_11> <https://discovery.ucl.ac.uk/id/person/ext-eac8846101c635ae1b69f470f7fbe882> .
<https://discovery.ucl.ac.uk/id/eprint/10057245> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-9ab33b592f325b7221b8ad2e36c85c98> .
<https://discovery.ucl.ac.uk/id/eprint/10057245> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10057245#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10057245#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_12> <https://discovery.ucl.ac.uk/id/person/ext-9ab33b592f325b7221b8ad2e36c85c98> .
<https://discovery.ucl.ac.uk/id/eprint/10057245> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-07b7112bd4d7fa9ae23ed9634f669aca> .
<https://discovery.ucl.ac.uk/id/eprint/10057245> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10057245#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10057245#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_13> <https://discovery.ucl.ac.uk/id/person/ext-07b7112bd4d7fa9ae23ed9634f669aca> .
<https://discovery.ucl.ac.uk/id/eprint/10057245> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-3572300dc9fb80d4c192e509c6b3db79> .
<https://discovery.ucl.ac.uk/id/eprint/10057245> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10057245#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10057245#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_14> <https://discovery.ucl.ac.uk/id/person/ext-3572300dc9fb80d4c192e509c6b3db79> .
<https://discovery.ucl.ac.uk/id/eprint/10057245> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-e02ee371ae854fe180312505bf065287> .
<https://discovery.ucl.ac.uk/id/eprint/10057245> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10057245#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10057245#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_15> <https://discovery.ucl.ac.uk/id/person/ext-e02ee371ae854fe180312505bf065287> .
<https://discovery.ucl.ac.uk/id/eprint/10057245> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-2ac651ab23feb9a50c929a1ec670a2c9> .
<https://discovery.ucl.ac.uk/id/eprint/10057245> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10057245#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10057245#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_16> <https://discovery.ucl.ac.uk/id/person/ext-2ac651ab23feb9a50c929a1ec670a2c9> .
<https://discovery.ucl.ac.uk/id/eprint/10057245> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-2d85db534d20def71d28e65e8bc94b43> .
<https://discovery.ucl.ac.uk/id/eprint/10057245> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10057245#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10057245#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_17> <https://discovery.ucl.ac.uk/id/person/ext-2d85db534d20def71d28e65e8bc94b43> .
<https://discovery.ucl.ac.uk/id/eprint/10057245> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-201113b216a3383b421bd522d13d468b> .
<https://discovery.ucl.ac.uk/id/eprint/10057245> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10057245#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10057245#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_18> <https://discovery.ucl.ac.uk/id/person/ext-201113b216a3383b421bd522d13d468b> .
<https://discovery.ucl.ac.uk/id/eprint/10057245> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-74c571f5f24653d5967b963747bd317c> .
<https://discovery.ucl.ac.uk/id/eprint/10057245> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10057245#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10057245#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_19> <https://discovery.ucl.ac.uk/id/person/ext-74c571f5f24653d5967b963747bd317c> .
<https://discovery.ucl.ac.uk/id/eprint/10057245> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-2ba29c1be8fd962bad37818a614fdc2d> .
<https://discovery.ucl.ac.uk/id/eprint/10057245> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10057245#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10057245#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_20> <https://discovery.ucl.ac.uk/id/person/ext-2ba29c1be8fd962bad37818a614fdc2d> .
<https://discovery.ucl.ac.uk/id/eprint/10057245> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-82bcffeaecd35453b2da047dd59bfcca> .
<https://discovery.ucl.ac.uk/id/eprint/10057245> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10057245#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10057245#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_21> <https://discovery.ucl.ac.uk/id/person/ext-82bcffeaecd35453b2da047dd59bfcca> .
<https://discovery.ucl.ac.uk/id/eprint/10057245> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-d2602dbc8bf39f737e222033bca88aac> .
<https://discovery.ucl.ac.uk/id/eprint/10057245> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10057245#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10057245#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_22> <https://discovery.ucl.ac.uk/id/person/ext-d2602dbc8bf39f737e222033bca88aac> .
<https://discovery.ucl.ac.uk/id/eprint/10057245> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-d37887f6495c745472c236309c86515f> .
<https://discovery.ucl.ac.uk/id/eprint/10057245> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10057245#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10057245#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_23> <https://discovery.ucl.ac.uk/id/person/ext-d37887f6495c745472c236309c86515f> .
<https://discovery.ucl.ac.uk/id/eprint/10057245> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-cb36c79f179daab9120b8407600f1afc> .
<https://discovery.ucl.ac.uk/id/eprint/10057245> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10057245#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10057245#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_24> <https://discovery.ucl.ac.uk/id/person/ext-cb36c79f179daab9120b8407600f1afc> .
<https://discovery.ucl.ac.uk/id/eprint/10057245> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-5b67d07d2d39ca737ff61949574bb801> .
<https://discovery.ucl.ac.uk/id/eprint/10057245> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10057245#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10057245#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_25> <https://discovery.ucl.ac.uk/id/person/ext-5b67d07d2d39ca737ff61949574bb801> .
<https://discovery.ucl.ac.uk/id/person/ext-5b67d07d2d39ca737ff61949574bb801> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-5b67d07d2d39ca737ff61949574bb801> <http://xmlns.com/foaf/0.1/givenName> "S"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-5b67d07d2d39ca737ff61949574bb801> <http://xmlns.com/foaf/0.1/familyName> "Hoelder"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-5b67d07d2d39ca737ff61949574bb801> <http://xmlns.com/foaf/0.1/name> "S Hoelder"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-4e4d8a1da9f3c822563ba2f15a23b1c1> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-4e4d8a1da9f3c822563ba2f15a23b1c1> <http://xmlns.com/foaf/0.1/givenName> "A"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-4e4d8a1da9f3c822563ba2f15a23b1c1> <http://xmlns.com/foaf/0.1/familyName> "Hayes"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-4e4d8a1da9f3c822563ba2f15a23b1c1> <http://xmlns.com/foaf/0.1/name> "A Hayes"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-2d85db534d20def71d28e65e8bc94b43> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-2d85db534d20def71d28e65e8bc94b43> <http://xmlns.com/foaf/0.1/givenName> "J"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-2d85db534d20def71d28e65e8bc94b43> <http://xmlns.com/foaf/0.1/familyName> "Schmitt"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-2d85db534d20def71d28e65e8bc94b43> <http://xmlns.com/foaf/0.1/name> "J Schmitt"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-4d49847ea96d0c5fa567d6117ad7d411> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-4d49847ea96d0c5fa567d6117ad7d411> <http://xmlns.com/foaf/0.1/givenName> "GWY"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-4d49847ea96d0c5fa567d6117ad7d411> <http://xmlns.com/foaf/0.1/familyName> "Mak"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-4d49847ea96d0c5fa567d6117ad7d411> <http://xmlns.com/foaf/0.1/name> "GWY Mak"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-e02ee371ae854fe180312505bf065287> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-e02ee371ae854fe180312505bf065287> <http://xmlns.com/foaf/0.1/givenName> "L"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-e02ee371ae854fe180312505bf065287> <http://xmlns.com/foaf/0.1/familyName> "O'Fee"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-e02ee371ae854fe180312505bf065287> <http://xmlns.com/foaf/0.1/name> "L O'Fee"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-07b7112bd4d7fa9ae23ed9634f669aca> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-07b7112bd4d7fa9ae23ed9634f669aca> <http://xmlns.com/foaf/0.1/givenName> "M"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-07b7112bd4d7fa9ae23ed9634f669aca> <http://xmlns.com/foaf/0.1/familyName> "Valenti"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-07b7112bd4d7fa9ae23ed9634f669aca> <http://xmlns.com/foaf/0.1/name> "M Valenti"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-1930895ef245aeb475bd9254e6381244> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-1930895ef245aeb475bd9254e6381244> <http://xmlns.com/foaf/0.1/givenName> "HL"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-1930895ef245aeb475bd9254e6381244> <http://xmlns.com/foaf/0.1/familyName> "Woodward"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-1930895ef245aeb475bd9254e6381244> <http://xmlns.com/foaf/0.1/name> "HL Woodward"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-74f69fc049e1c5b1e7572847ab17c169> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-74f69fc049e1c5b1e7572847ab17c169> <http://xmlns.com/foaf/0.1/givenName> "AT"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-74f69fc049e1c5b1e7572847ab17c169> <http://xmlns.com/foaf/0.1/familyName> "Henley"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-74f69fc049e1c5b1e7572847ab17c169> <http://xmlns.com/foaf/0.1/name> "AT Henley"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-46b3fc4ec8f14b55779ae1df5c205fab> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-46b3fc4ec8f14b55779ae1df5c205fab> <http://xmlns.com/foaf/0.1/givenName> "A"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-46b3fc4ec8f14b55779ae1df5c205fab> <http://xmlns.com/foaf/0.1/familyName> "Faisal"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-46b3fc4ec8f14b55779ae1df5c205fab> <http://xmlns.com/foaf/0.1/name> "A Faisal"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-d2602dbc8bf39f737e222033bca88aac> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-d2602dbc8bf39f737e222033bca88aac> <http://xmlns.com/foaf/0.1/givenName> "SA"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-d2602dbc8bf39f737e222033bca88aac> <http://xmlns.com/foaf/0.1/familyName> "Eccles"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-d2602dbc8bf39f737e222033bca88aac> <http://xmlns.com/foaf/0.1/name> "SA Eccles"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-d37887f6495c745472c236309c86515f> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-d37887f6495c745472c236309c86515f> <http://xmlns.com/foaf/0.1/givenName> "S"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-d37887f6495c745472c236309c86515f> <http://xmlns.com/foaf/0.1/familyName> "Linardopoulos"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-d37887f6495c745472c236309c86515f> <http://xmlns.com/foaf/0.1/name> "S Linardopoulos"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-f1d7f0ac06a79f89abd1b73407285e92> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-f1d7f0ac06a79f89abd1b73407285e92> <http://xmlns.com/foaf/0.1/givenName> "G"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-f1d7f0ac06a79f89abd1b73407285e92> <http://xmlns.com/foaf/0.1/familyName> "Box"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-f1d7f0ac06a79f89abd1b73407285e92> <http://xmlns.com/foaf/0.1/name> "G Box"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-eac8846101c635ae1b69f470f7fbe882> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-eac8846101c635ae1b69f470f7fbe882> <http://xmlns.com/foaf/0.1/givenName> "N"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-eac8846101c635ae1b69f470f7fbe882> <http://xmlns.com/foaf/0.1/familyName> "Cronin"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-eac8846101c635ae1b69f470f7fbe882> <http://xmlns.com/foaf/0.1/name> "N Cronin"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-201113b216a3383b421bd522d13d468b> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-201113b216a3383b421bd522d13d468b> <http://xmlns.com/foaf/0.1/givenName> "R"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-201113b216a3383b421bd522d13d468b> <http://xmlns.com/foaf/0.1/familyName> "Burke"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-201113b216a3383b421bd522d13d468b> <http://xmlns.com/foaf/0.1/name> "R Burke"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-1e61e764668b2cfe2c84f3c6006ece31> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-1e61e764668b2cfe2c84f3c6006ece31> <http://xmlns.com/foaf/0.1/givenName> "J"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-1e61e764668b2cfe2c84f3c6006ece31> <http://xmlns.com/foaf/0.1/familyName> "Roberts"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-1e61e764668b2cfe2c84f3c6006ece31> <http://xmlns.com/foaf/0.1/name> "J Roberts"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-3572300dc9fb80d4c192e509c6b3db79> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-3572300dc9fb80d4c192e509c6b3db79> <http://xmlns.com/foaf/0.1/givenName> "A"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-3572300dc9fb80d4c192e509c6b3db79> <http://xmlns.com/foaf/0.1/familyName> "De Haven Brandon"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-3572300dc9fb80d4c192e509c6b3db79> <http://xmlns.com/foaf/0.1/name> "A De Haven Brandon"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-74c571f5f24653d5967b963747bd317c> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-74c571f5f24653d5967b963747bd317c> <http://xmlns.com/foaf/0.1/givenName> "F"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-74c571f5f24653d5967b963747bd317c> <http://xmlns.com/foaf/0.1/familyName> "Broccatelli"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-74c571f5f24653d5967b963747bd317c> <http://xmlns.com/foaf/0.1/name> "F Broccatelli"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-2ac651ab23feb9a50c929a1ec670a2c9> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-2ac651ab23feb9a50c929a1ec670a2c9> <http://xmlns.com/foaf/0.1/givenName> "H"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-2ac651ab23feb9a50c929a1ec670a2c9> <http://xmlns.com/foaf/0.1/familyName> "Saville"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-2ac651ab23feb9a50c929a1ec670a2c9> <http://xmlns.com/foaf/0.1/name> "H Saville"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-962ab330cf148f9347c74467ce159409> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-962ab330cf148f9347c74467ce159409> <http://xmlns.com/foaf/0.1/givenName> "P"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-962ab330cf148f9347c74467ce159409> <http://xmlns.com/foaf/0.1/familyName> "Innocenti"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-962ab330cf148f9347c74467ce159409> <http://xmlns.com/foaf/0.1/name> "P Innocenti"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-cb36c79f179daab9120b8407600f1afc> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-cb36c79f179daab9120b8407600f1afc> <http://xmlns.com/foaf/0.1/givenName> "J"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-cb36c79f179daab9120b8407600f1afc> <http://xmlns.com/foaf/0.1/familyName> "Blagg"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-cb36c79f179daab9120b8407600f1afc> <http://xmlns.com/foaf/0.1/name> "J Blagg"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-2ba29c1be8fd962bad37818a614fdc2d> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-2ba29c1be8fd962bad37818a614fdc2d> <http://xmlns.com/foaf/0.1/givenName> "RLM"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-2ba29c1be8fd962bad37818a614fdc2d> <http://xmlns.com/foaf/0.1/familyName> "Van Montfort"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-2ba29c1be8fd962bad37818a614fdc2d> <http://xmlns.com/foaf/0.1/name> "RLM Van Montfort"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-6a41a6f99fadfac82820d2df00621c59> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-6a41a6f99fadfac82820d2df00621c59> <http://xmlns.com/foaf/0.1/givenName> "IM"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-6a41a6f99fadfac82820d2df00621c59> <http://xmlns.com/foaf/0.1/familyName> "Westwood"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-6a41a6f99fadfac82820d2df00621c59> <http://xmlns.com/foaf/0.1/name> "IM Westwood"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-82bcffeaecd35453b2da047dd59bfcca> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-82bcffeaecd35453b2da047dd59bfcca> <http://xmlns.com/foaf/0.1/givenName> "FI"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-82bcffeaecd35453b2da047dd59bfcca> <http://xmlns.com/foaf/0.1/familyName> "Raynaud"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-82bcffeaecd35453b2da047dd59bfcca> <http://xmlns.com/foaf/0.1/name> "FI Raynaud"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-9ab33b592f325b7221b8ad2e36c85c98> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-9ab33b592f325b7221b8ad2e36c85c98> <http://xmlns.com/foaf/0.1/givenName> "M"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-9ab33b592f325b7221b8ad2e36c85c98> <http://xmlns.com/foaf/0.1/familyName> "Carter"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-9ab33b592f325b7221b8ad2e36c85c98> <http://xmlns.com/foaf/0.1/name> "M Carter"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-83d86b788ed7a51f3b8a49cf0e8abaa9> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-83d86b788ed7a51f3b8a49cf0e8abaa9> <http://xmlns.com/foaf/0.1/givenName> "KMJ"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-83d86b788ed7a51f3b8a49cf0e8abaa9> <http://xmlns.com/foaf/0.1/familyName> "Cheung"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-83d86b788ed7a51f3b8a49cf0e8abaa9> <http://xmlns.com/foaf/0.1/name> "KMJ Cheung"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10057245> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/EPrint> .
<https://discovery.ucl.ac.uk/id/eprint/10057245> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/ArticleEPrint> .
<https://discovery.ucl.ac.uk/id/eprint/10057245> <http://purl.org/dc/terms/isPartOf> <https://discovery.ucl.ac.uk/id/repository> .
<https://discovery.ucl.ac.uk/id/eprint/10057245> <http://eprints.org/ontology/hasDocument> <https://discovery.ucl.ac.uk/id/document/743948> .
<https://discovery.ucl.ac.uk/id/document/743948> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/Document> .
<https://discovery.ucl.ac.uk/id/document/743948> <http://www.w3.org/2000/01/rdf-schema#label> "Introduction of a Methyl Group Curbs Metabolism of Pyrido[3,4-d]pyrimidine Monopolar Spindle 1 (MPS1) Inhibitors and Enables the Discovery of the Phase 1 Clinical Candidate N2-(2-Ethoxy-4-(4-methyl-4H-1,2,4-triazol-3-yl)phenyl)-6-methyl-N8-neopentylpyrido[3,4-d]pyrimidine-2,8-diamine (BOS172722) (Text)"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10057245> <http://purl.org/dc/elements/1.1/hasVersion> <https://discovery.ucl.ac.uk/id/document/743948> .
<https://discovery.ucl.ac.uk/id/eprint/10057245> <http://eprints.org/ontology/hasPublished> <https://discovery.ucl.ac.uk/id/document/743948> .
<https://discovery.ucl.ac.uk/id/document/743948> <http://eprints.org/ontology/hasFile> <https://discovery.ucl.ac.uk/id/eprint/10057245/1/acs.jmedchem.8b00690.pdf> .
<https://discovery.ucl.ac.uk/id/document/743948> <http://purl.org/dc/terms/hasPart> <https://discovery.ucl.ac.uk/id/eprint/10057245/1/acs.jmedchem.8b00690.pdf> .
<https://discovery.ucl.ac.uk/id/eprint/10057245/1/acs.jmedchem.8b00690.pdf> <http://www.w3.org/2000/01/rdf-schema#label> "acs.jmedchem.8b00690.pdf"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10057245> <http://eprints.org/ontology/hasDocument> <https://discovery.ucl.ac.uk/id/document/743949> .
<https://discovery.ucl.ac.uk/id/document/743949> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/Document> .
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