eprintid: 10056971 rev_number: 19 eprint_status: archive userid: 608 dir: disk0/10/05/69/71 datestamp: 2018-09-28 09:52:53 lastmod: 2020-02-17 05:02:49 status_changed: 2018-09-28 09:52:53 type: article metadata_visibility: show creators_name: Zafeiropoulos, GC creators_name: Papadimitriou, KI creators_name: Drakakis, EM title: Performance ANd ACcuracy in Electrical BioActivity Recordings (PANACEA): A high-performance, wireless, multi-instrument for potentiometric and amperometric recording of biosignals ispublished: pub divisions: UCL divisions: A01 divisions: B04 divisions: C05 keywords: High-performance, Wireless, Biosignal, Potentiometry, Amperometry, EEG, ECoG, ECG, EMG, ZigBee Protocol note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. abstract: This paper presents the design, testing and quantitative evaluation of a high-performance, low-power, portable multi-instrument (107×79mm2), capable of recording important biosignals accurately and in real-time. This highly versatile system has the ability to transmit the captured bio-data back to the user either in a wired (HDMI cable) or wireless (ZigBee protocol) manner, depending on the targeted application. The biological information that can be recorded by the proposed instrument spans a wide range of bio-potentials and bio-amperometric signals. The proposed instrument is split into two complementary “sub-instruments” where one is operating as the front-end device, responsible for the accurate, low-noise signal detection and transmission, while the second “sub-instrument” is operating as the “base station” responsible for the collection and further processing of the captured data. For wired transmission (e.g to the user's PC) the front end module can operate independently, however, for wireless transmission both “sub-instruments” are required (transmitter-base station architecture). For wireless transmission, each of the two “sub-instruments” is equipped with dedicated 2 Mbps ZigBee radio transceivers and both parts are controlled by a small area embedded FPGA module. The front-end device features two distinct sections: (a) a current/voltage to voltage section comprising six potentiometry and two transimpedance amplifier-based amperometry channels. These eight in total analogue channels are converted into digital form by means of a 24 bit, voltage input, Analogue-to-Digital Converter (ADC) and (b) a four channel, commercially available switched-capacitor-based ADC Integrated Circuit (IC), which converts input charge to digital data with 16 or 20 bit resolution at 3.125 kSPS. The paper presents a plethora of measured wired and wireless experimental results, corresponding to most well-known biomedical and other biological/physical signals including: EEG, ECoG, EMG, ECG, PPG, intracardiac atrial fibrillation (AF) signals, cell media/tissue biopotential, drosophila H1-cell spiking signals and pH sensing using commercially available electrodes. The portable/wearable poly-instrument is suitable for Intensive Care Unit (ICU), High Dependancy Unit (HDU) as well as home monitoring. date: 2018-12-01 date_type: published official_url: http://dx.doi.org/10.1016/j.measurement.2018.05.115 oa_status: green full_text_type: other language: eng primo: open primo_central: open_green article_type_text: Journal Article verified: verified_manual elements_id: 1570471 doi: 10.1016/j.measurement.2018.05.115 lyricists_name: Papadimitriou, Konstantinos lyricists_id: KPAPA49 actors_name: Papadimitriou, Konstantinos actors_name: Turnbull, Sarah actors_id: KPAPA49 actors_id: SLTUR91 actors_role: owner actors_role: impersonator full_text_status: public publication: Measurement: Journal of the International Measurement Confederation volume: 129 pagerange: 128-141 issn: 0263-2241 citation: Zafeiropoulos, GC; Papadimitriou, KI; Drakakis, EM; (2018) Performance ANd ACcuracy in Electrical BioActivity Recordings (PANACEA): A high-performance, wireless, multi-instrument for potentiometric and amperometric recording of biosignals. Measurement: Journal of the International Measurement Confederation , 129 pp. 128-141. 10.1016/j.measurement.2018.05.115 <https://doi.org/10.1016/j.measurement.2018.05.115>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10056971/1/Manuscript_Accepted_Preprint.pdf