eprintid: 10056826
rev_number: 20
eprint_status: archive
userid: 608
dir: disk0/10/05/68/26
datestamp: 2018-09-24 12:40:22
lastmod: 2021-09-17 22:06:43
status_changed: 2018-09-24 12:40:22
type: article
metadata_visibility: show
creators_name: Hall, S
creators_name: Janelidze, S
creators_name: Surova, Y
creators_name: Widner, H
creators_name: Zetterberg, H
creators_name: Hansson, O
title: Cerebrospinal fluid concentrations of inflammatory markers in Parkinson's disease and atypical parkinsonian disorders
ispublished: pub
divisions: UCL
divisions: B02
divisions: C07
divisions: D07
divisions: F86
keywords: Science & Technology, Multidisciplinary Sciences, Science & Technology - Other Topics, PROGRESSIVE SUPRANUCLEAR PALSY, MULTIPLE SYSTEM ATROPHY, MICROGLIAL ACTIVATION, DIAGNOSTIC-CRITERIA, RATING-SCALE, DEMENTIA, ASTROCYTES, DEPRESSION, ALZHEIMERS, BIOMARKERS
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abstract: Inflammation has been implicated in the pathogenesis of Parkinson’s disease (PD). We here investigate levels of inflammatory biomarkers in cerebrospinal fluid (CSF) in PD and atypical parkinsonian disorders (APD) compared with neurologically healthy controls. We included 131 patients with PD and 27 PD with dementia (PDD), 24 with multiple system atrophy (MSA), 14 with progressive supranuclear palsy (PSP) and 50 controls, all part of the Swedish BioFINDER study. CSF was analyzed for CRP, SAA, IL-6, IL-8, YKL-40 and MCP-1 (CCL2) as well as α-synuclein (α-syn), tau, tau phosphorylated at Thr181 (P-tau), Aβ42 and NfL. In this exploratory study, we found higher levels of the inflammatory biomarker SAA in PDD and MSA compared with controls and PD and higher levels of CRP in PDD and MSA compared with PD. YKL-40 was lower in PD compared with controls. There were multiple positive correlations between the inflammatory markers, α-syn and markers of neuroaxonal injury (NfL and tau). In PD, higher levels of inflammatory biomarkers correlated with worse motor function and cognitive impairment. Thus, inflammatory biomarkers were increased in PDD and MSA. Furthermore, inflammatory biomarkers correlated with more severe disease regarding motor symptoms and cognitive impairment in PD, indicating an association between inflammation and more aggressive disease course. However, the results need confirmation in follow-up studies.
date: 2018-09-05
date_type: published
publisher: NATURE PUBLISHING GROUP
official_url: http://dx.doi.org/10.1038/s41598-018-31517-z
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
article_type_text: Article
verified: verified_manual
elements_id: 1582323
doi: 10.1038/s41598-018-31517-z
lyricists_name: Zetterberg, Henrik
lyricists_id: HZETT94
actors_name: Bracey, Alan
actors_id: ABBRA90
actors_role: owner
full_text_status: public
publication: Scientific Reports
volume: 8
article_number: 13276
pages: 9
issn: 2045-2322
citation:        Hall, S;    Janelidze, S;    Surova, Y;    Widner, H;    Zetterberg, H;    Hansson, O;      (2018)    Cerebrospinal fluid concentrations of inflammatory markers in Parkinson's disease and atypical parkinsonian disorders.                   Scientific Reports , 8     , Article 13276.  10.1038/s41598-018-31517-z <https://doi.org/10.1038/s41598-018-31517-z>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10056826/1/s41598-018-31517-z.pdf