TY  - JOUR
KW  - Alzheimer's disease
KW  -  CSF biomarkers
KW  -  Exercise
KW  -  Physical activity
KW  -  Sedentary behavior
A1  - Law, LL
A1  - Rol, RN
A1  - Schultz, SA
A1  - Dougherty, RJ
A1  - Edwards, DF
A1  - Koscik, RL
A1  - Gallagher, CL
A1  - Carlsson, CM
A1  - Bendlin, BB
A1  - Zetterberg, H
A1  - Blennow, K
A1  - Asthana, S
A1  - Sager, MA
A1  - Hermann, BP
A1  - Johnson, SC
A1  - Cook, DB
A1  - Okonkwo, OC
JF  - Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
SN  - 2352-8729
UR  - https://doi.org/10.1016/j.dadm.2018.01.001
ID  - discovery10056600
N2  - INTRODUCTION:
Alzheimer's disease (AD) is characterized by the presence of amyloid ? (A?) plaques, neurofibrillary tangles, and neurodegeneration, evidence of which may be detected in vivo via cerebrospinal fluid (CSF) sampling. Physical activity (PA) has emerged as a possible modifier of these AD-related pathological changes. Consequently, the aim of this study was to cross-sectionally examine the relationship between objectively measured PA and CSF levels of A?42 and tau in asymptomatic late-middle-aged adults at risk for AD.

METHODS:
Eighty-five cognitively healthy late-middle-aged adults (age = 64.31 years, 61.2% female) from the Wisconsin Registry for Alzheimer's Prevention participated in this study. They wore an accelerometer (ActiGraph GT3X+) for one week to record free-living PA, yielding measures of sedentariness and various intensities of PA (i.e., light, moderate, and vigorous). They also underwent lumbar puncture to collect CSF, from which A?42, total tau, and phosphorylated tau were immunoassayed. Regression analyses were used to examine the association between accelerometer measures and CSF biomarkers, adjusting for age, sex, and other relevant covariates.

RESULTS:
Engagement in moderate PA was associated with higher A?42 (P = .008), lower total tau/A?42 (P = .006), and lower phosphorylated tau/A?42 (P = .030). In contrast, neither light nor vigorous PA was associated with any of the biomarkers. Increased sedentariness was associated with reduced A?42 (P = .014).

DISCUSSIONS:
In this cohort, moderate PA, but not light or vigorous, was associated with a favorable AD biomarker profile, while sedentariness was associated with greater A? burden. These findings suggest that a physically active lifestyle may play a protective role against the development of AD.
N1  - This is an open access article under the CC BY-NC-ND
license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
EP  - 195
AV  - public
VL  - 10
Y1  - 2018/02//
SP  - 188
TI  - Moderate intensity physical activity associates with CSF biomarkers in a cohort at risk for Alzheimer's disease
ER  -